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anti-Human BHMT Antibodies:
anti-Mouse (Murine) BHMT Antibodies:
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Human Polyclonal BHMT Primary Antibody for ELISA, IHC - ABIN314263
Geillinger, Rathmann, Köhrle, Fiamoncini, Daniel, Kipp: Hepatic metabolite profiles in mice with a suboptimal selenium status. in The Journal of nutritional biochemistry 2014
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Human Polyclonal BHMT Primary Antibody for ELISA, IHC - ABIN334358
Collinsova, Strakova, Jiracek, Garrow: Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. in The Journal of nutrition 2006
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Cow (Bovine) Polyclonal BHMT Primary Antibody for IHC, WB - ABIN2773785
Castro, Gratson, Evans, Jiracek, Collinsová, Ludwig, Garrow: Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. in Biochemistry 2004
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Dog (Canine) Polyclonal BHMT Primary Antibody for ELISA, WB - ABIN548161
Tikhanovich, Kuravi, Campbell, Kharbanda, Artigues, Villar, Weinman: Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure. in Hepatology (Baltimore, Md.) 2013
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Human Monoclonal BHMT Primary Antibody for IHC, ELISA - ABIN968978
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
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It can be inferred from the data obtained that folate system genetic variants and mild hyperhomocysteimenia may affect ADHD associated traits by attenuating folate metabolism.
Our study suggested markers in BHMT/BHMT2 and DMGDH might affect the risk of NSCL/P through pairwise interaction.
BHMT (rs3733890) polymorphism showed no association with ALL. Hence this investigation needs further evaluation in larger sample size and effect of other SNPs, CNVs and miRNA's is required to elucidate the role of BHMT gene in ALL development.
In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
It was concluded that during pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.
low BHMT expression is correlated with aggressive malignant phenotype of HCC. Our data indicate that BHMT may serve as a novel prognostic marker for HCC.
The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT.
Multiple SNPs in BHMT and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements.
Data suggest BHMT is activated by binding of potassium ions; role of potassium ions in BHMT appears to be structural; potassium ions facilitate specific binding of substrate homocysteine (rather than substrate betaine) to active site of the enzyme.
Study suggests BHMT holds considerable potential as a blood biomarker for acute liver injury.
Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy.
Known common single-nucleotide polymorphisms in MTRR and BHMT genes may not be significant risk factors for cororonary artery disease.
Our study suggests that the polymorphism BHMT G742A may modulate the Down syndrome risk in Brazilian mothers.
The BHMT 742GA or AA genotypes associated with tobacco consumption (P = 0.016) increase the risk for head and neck squamous cell carcinoma.
A transcription variant of exon 4 of betaine-homocysteine methyltransferase (BHMT) produces a loss of function of BHMT in human hepatocarcinoma
Three SNPs (rs41272270, rs16876512, and rs6875201), located 28kb upstream, in the 5'-UTR and in intron 1 of BHMT, respectively, were significantly correlated with both BHMT activity and protein levels.
No significant level of association was found with cleft lip with or without cleft palate and BHMT variants.
Results might suggest the protective role of the BHMT 239Gln variant in cervical cancer incidence.
This suggests that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner.
gene-gene interaction analysis revealed significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility.
These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
Data indicate that improved Sp1 transcription factor (Sp1) and betaine homocysteine-S-methyltransferase (BHMT) expression are involved in the effects of zinc on oxidative stress.
Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging volume, as well as impaired reference and short-term memories.
BHMT expression is robustly regulated by taurine.
It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked.
mouse blastocysts are unusual in being able to generate AdoMet not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT
a role for BHMT in energy homeostasis.
BHMT has an important role in Hcy, choline, and one-carbon homeostasis
The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death.
function for Bhmt involving modulation of Shh signaling to control beta-cell development.
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
betaine--homocysteine S-methyltransferase 1
, betaine-homocysteine methyltransferase