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GG homozygous and G alleles of methionine synthase A2756G polymorphism were not associated with risks of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), the subtype of NHL including the diffuse large B-cell lymphoma and follicular lymphoma.
SNPs in folate pathway genes MTHFR (show MTHFR Proteins)/ MTR/ACE (show ACE Proteins) and hyperhomocysteinemia have roles in risk of coronary artery disease.
Data indicate that two noncoding 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) variants, rs28372871 and rs1131450 were independently associated with a significantly increased risk of prostate cancer (PCa (show FLVCR1 Proteins)).
Based on the results, an MTRA2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men.
MTR CpG sites were hypermethylated in preterm placenta. Methylated CpG sites were negatively associated with maternal plasma vitamin B12 (show NDUFB3 Proteins) levels.
tagSNPs in MTHFR (show MTHFR Proteins), MTR, MTRR (show MTRR Proteins), and TCN2 (show TCN2 Proteins) were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.
MTHFR (show MTHFR Proteins) A1298C and MS A2756G polymorphisms may be unrelated to male infertility.
The evaluation of genetic association showed that, MTHFR (show MTHFR Proteins) C6877T (OR: 8.89, 95% CI: 2.01-39.40) and MTR A2756G (OR: 1.48, 95% CI: 1.09-2.00) polymorphisms associated with higher risk of CVD.
The MTR A2756G, MTRR (show MTRR Proteins) A66G, MTHFR (show MTHFR Proteins) C677T and MTHFR (show MTHFR Proteins) A1298C polymorphisms were assessed. MTR A2756G, MTRR (show MTRR Proteins) A66G, and MTHFR (show MTHFR Proteins) C677T gene polymorphisms were associated with the risk of NSCL (show NHLH1 Proteins)/P (all p < 0.05). Logistic regression analysis revealed that MTR A2756G, MTR RA66G, and MTHFR (show MTHFR Proteins) C667T might increase the risk of Nonsyndromic Cleft Lip/Palate
we examined the association between methylenetetrahydrofolate reductase (MTHFR (show MTHFR Proteins) C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer. We found an association between MTHFR (show MTHFR Proteins) C677T polymorphism and risks to both thyroid (OR = 2.50; 95%CI = 1.15-5.46; P = 0.02) and breast cancer (OR = 2.53; 95%CI = 1.08-5.93; P = 0.03).
These findings indicate that greater synthesis of phosphatidylcholine (show SGMS1 Proteins) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.
5-methyltetrahydrofolate-homocysteine methyltransferase 1
, cobalamin-dependent methionine synthase
, methionine synthase
, vitamin-B12 dependent methionine synthase
, 5-methyltetrahydrofolate--homocysteine methyltransferase