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ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly.
Katanin Severing and Binding Microtubules Are Inhibited by Tubulin (show TUBB Proteins) Carboxy Tails
Data propose a model in which spatial rearrangement of the p60 katanin N-terminal domain relative to the C-terminal AAA (show APP Proteins) domain may be important for productive ATP hydrolysis towards MT-severing.
Katanin p60 was aberrantly expressed during prostate cancer progression. The elevated katanin p60 expression may contribute to cancer cell metastasis via a stimulatory effect on cell motility.
A common substrate recognition mode conserved between katanin p60 and VPS4 (show VPS4A Proteins) governs microtubule severing and membrane skeleton reorganization
LAPSER1 (show LZTS2 Proteins) C terminal domain inhibits katanin(p80 (show KATNB1 Proteins)/p60)-mediated microtubule severing in vitro.
Our results suggest that LECT2 (show LECT2 Proteins) regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 (show STIP1 Proteins) levels.
A common substrate recognition mode conserved between katanin p60 (show STIP1 Proteins) and VPS4 (show VPS4A Proteins) governs microtubule severing and membrane skeleton reorganization
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.
katanin p60 (ATPase-containing) subunit A 1
, katanin p60 ATPase-containing subunit A1
, katanin p60 subunit A1
, p60 katanin
, katanin p60 subunit A 1
, microtubule severing protein
, Katanin p60 subunit A1