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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
The findings of the present study indicate that miR (show MYLIP Proteins)-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.
Data show that Rock2 acts as a negative regulator of the TGFbeta (show TGFB1 Proteins) signaling pathway.
by differentially affecting CyPA (show PPIA Proteins) and Bsg expressions, ROCK1 (show ROCK1 Proteins) protects and ROCK2 jeopardizes the heart from pressure-overload heart failure with postcapillary pulmonary hypertension, for which celastrol may be a promising agent.
Data indicate that Rho-associated protein kinase (ROCK)-dependent intermittent T cell migration regulates tissue-sampling during acute lung injury.
A specific inhibitor of ROCK, Y-27632, was used to examine the role of ROCK in mouse colitis models. ROCK1 (show ROCK1 Proteins) and ROCK2 were silenced respectively using RNA interference in Caco-2 cells. The expression of tight junction proteins and the downstream molecules of ROCK were assessed
that platelet ROCK2 plays important role in platelet function and thrombosis, but does not contribute to the pathogenesis of atherosclerosis and vascular remodeling
This study showed that , APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins))-mediated degradation of Rock2 maintains the dendritic network, memory formation, and neuronal survival, suggesting that pharmacological inhibition of aberrantly accumulated Rock2 may be a suitable therapeutic strategy against neurodegeneration.
data suggest that activation of ROCK2 in adipose tissue contributes to obesity-induced insulin (show INS Proteins) resistance; this may result in part from suppression of PPARgamma (show PPARG Proteins) expression, leading to adipocyte hypertrophy and an increase in inflammatory cytokine production; ROCK2 may be a suitable target to improve insulin (show INS Proteins) sensitivity in obesity
ROCK2 contributes to allergic airways responses likely via effects within ASM (show SMPD1 Proteins) cells and within non-lymphocyte cells involved in lymphocyte activation and migration into the airways.
BRAF (show BRAF Proteins) and ROKalpha form independent RAF1 (show RAF1 Proteins) complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (show EGF Proteins)).
Dexamethasone up-regulates ROCK1 (show ROCK1 Proteins)/2 activity promoting migration, invasion and metastasis of melanoma cells.
these data suggest that ROCK2 signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 (show STAT3 Proteins) and STAT5 (show STAT5A Proteins) activation.
Upregulation of ROCK2 was associated with the progression of breast cancer.
ROCK2 participates in cell adhesion by regulating ICAM-1 (show ICAM1 Proteins) expression and the co-localization of adhesion molecules with vimentin (show VIM Proteins).
qPCR demonstrated that melatonin downregulated ROCK2 gene expression, and upregulated the expression of the ZO1 (show TJP1 Proteins) and occludin (show OCLN Proteins) genes. The levels of ZO1 (show TJP1 Proteins) and occludin (show OCLN Proteins) localized in the tight junctions were markedly increased in the immunofluorescence assay.
This study showed that ROCK2 expression significantly increased in clinical gastric cancer tissues compared with adjacent non-cancer tissues.
The findings indicate that upregulation of the RhoA (show RHOA Proteins)/ROCK pathway is significantly associated with cardiac hypertrophy-related Ca2 (show CA2 Proteins)+ dysregulation and suggest that ROCK inhibition prevents hypertrophic heart failure.
RhoA (show RHOA Proteins) is activated in tumors from neuroblastoma (show ARHGEF16 Proteins) patients, and elevated expression of Rho-associated kinase (show ROCK1 Proteins) (ROCK)2 is associated with poor patient survival. Pharmacological or genetic inhibition of ROCK1 (show ROCK1 Proteins) and 2, key molecules in Rho signaling, resulted in neuroblastoma (show ARHGEF16 Proteins) cell differentiation and inhibition of neuroblastoma (show ARHGEF16 Proteins) cell growth, migration, and invasion.
ROCK1 (show ROCK1 Proteins) and ROCK2 contribute to the genetic susceptibility of hypertension and stroke.
these data indicate that ROCK proteins are overexpressed in diverse vascular tumors and suggest that specific targeting of ROCK2 proteins may show efficacy against malignant vascular tumors.
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB (show NFKB1 Proteins) pathways.
The increase in protein expression of ROCK2 in astrocytes and microglia suggests an important role for ROCK2 in glial Parkinson disease pathology, which is initiated already in normal aging.
Results indicate that ROCK1 (show ROCK1 Proteins) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.
It is highly possible that Rho-kinase (show ROCK1 Proteins) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (show ROCK1 Proteins) is not involved in endothelial regeneration after vascular injury.
Rho-kinase (show ROCK1 Proteins) analysis of coiled-coil association of the RhoA (show RHOA Proteins)-binding domain
RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.
nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Rho-associated kinase alpha
, rho-associated protein kinase 2
, rho-associated, coiled-coil containing protein kinase 2
, Rho-associated, coiled-coil containing protein kinase 2
, rho-associated protein kinase 2-like
, Rho-associated coiled-coil forming kinage 2
, p164 ROCK-2
, rho-associated, coiled-coil-containing protein kinase 2
, rho-associated, coiled-coil-containing protein kinase II
, Rho-associated coiled-coil forming kinase 2
, RhoA - binding serine/threosine kinase alpha (ROK - alpha)
, p150 ROK-alpha
, rhoA-binding kinase 2
, Rho-kinase alpha