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Human TUBA4A Protein expressed in Wheat germ - ABIN1324116
Ndhlovu, Preuss, Dengjel, Stevanovic, Weiner, Klein: Identification of ?-tubulin as an autoantigen recognized by sera from patients with neuropsychiatric systemic lupus erythematosus. in Brain, behavior, and immunity 2011
Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS).
The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset.
alphaTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection
Its mutations were seen in patients with ALS and frontotemporal dementia.
TUBA4A mutations are not associated with FTD.
In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required.
This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein.
TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability
TUBA4A is significantly increased in spermatazoa from men with azoospermia.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
The results suggested that cytoskeletal alterations in the amygdala determined by tubulin seem to be involved in the pathophysiology of drug addiction
Subunits of alphaB crystallin that exchange dynamically with the alphaB crystallin complex can interact with tubulin subunits to regulate the equilibrium between tubulin and microtubules.
increased levels in paclitaxel-resistant breast cancer cells
Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin.
Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions.
These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
tubulin, alpha 1 (testis specific)
, tubulin, alpha 6
, tubulin H2-alpha
, tubulin alpha-1 chain
, tubulin alpha-4A chain
, alpha-tubulin 4
, alpha-tubulin isotype M-alpha-4
, tubulin alpha-4 chain
, tubulin, alpha 4
, alpha-tubulin 1
, tubulin, alpha 1
, tubulin alpha 4a
, tubulin, alpha 4a