Browse our TUBB2B Proteins (TUBB2B)

Full name:: Tubulin, beta 2B Proteins (TUBB2B)

On www.antibodies-online.com are 6 Tubulin, beta 2B (TUBB2B) Proteins from 4 different suppliers available. Additionally we are shipping TUBB2B Antibodies (59) and many more products for this protein. A total of 69 TUBB2B products are currently listed.

Synonyms:: 2410129E14Rik, bA506K6.1, fb40f09, N-Tub, n-tubulin, NBT, NST, ntubulin, PMGYSA, RGD1309427, TUBB, TUBB2, TUBB2A, TUBB2B, tubb2c, wu:fb40f09, Xn-tubulin, zgc:123194

list all proteins	Gene Name	GeneID	UniProt
	TUBB2B	73710	Q9CWF2
	TUBB2B	291081	Q3KRE8
	TUBB2B	347733	Q9BVA1
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TUBB2B Proteins (TUBB2B) by Origin

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Relevant Pathways for TUBB2B Proteins

Microtubule Dynamics

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Cow (Bovine) Tubulin, beta 2B (TUBB2B) interaction partners

A combination of molecular dynamics simulations and computational docking is used to identify a single high-affinity binding site on five beta-tubulin (show TUBB Proteins) microtubule inhibitors adjacent to the exchangeable GTP (show AK3 Proteins) site on beta-tubulin (show TUBB Proteins).
Results suggest that the axonemal motif sequences of betaI, betaIV and betaV tubulin (show TUBB Proteins) are essential for ciliary function.
These data indicate that phosphorylation of tubulin (show TUBB Proteins) by Cdk1 (show CDK1 Proteins) could be involved in the regulation of microtubule dynamics during mitosis.

Mouse (Murine) Tubulin, beta 2B (TUBB2B) interaction partners

The data presented here demonstrate that a heterozygous Tubb2b brdp/+ mutation in mice leads to significant spatial learning and memory reductions and conditioned contextual, but not cued, fear deficits.
study shows TUBB2B significantly upregulated in melanoma multinucleated giant cells, which indicates that it may play an important role in melanoma metastasis.
Study showed that Tubb2b is expressed in Sox2 (show SOX2 Proteins)- and Tbr2 (show EOMES Proteins)-positive neuronal progenitors and, at higher levels, in Dcx (show DCX Proteins)-positive postmitotic neurons in the developing mouse neocortex
Results show that the missense mutation at a highly conserved residue (N247S) in Tubb2b gene represents the most severely affected mouse tubulin (show TUBB Proteins) phenotype involving neuronal proliferation and survival.

Human Tubulin, beta 2B (TUBB2B) interaction partners

The TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and reinforces the sensitivity of the developing cerebellum to microtubule defects.
At the cellular level, the p.Cys239Phe TUBB2B mutant leads to tubulin (show TUBB Proteins) heterodimerization impairment, decreased ability to incorporate into the cytoskeleton, microtubule dynamics alteration, with an accelerated rate of depolymerization
off-target, non-immune mediated effects of the mTOR (show FRAP1 Proteins)-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 (show DCDC2 Proteins) in glomerular podocyte development
The association of polymicrogyria with thin or absent corpus callosum, dysmorphic basal ganglia, brainstem and vermis hypoplasia is highly likely to result from mutations in TUBB2B.
The present study confirms that mutations in tubulin (show TUBB Proteins) genes are responsible for complex brain malformation.
Congenital fibrosis of the extraocular muscles and intellectual disability segregate with a heterozygous mutation in TUBB2B.
The TUBB2B and TUBA1 (show TUBA4A Proteins) coding regions have been sequenced in patients with cortical malformations associated with these genes.
Three new TUBB2B mutations have been identified in three unrelated patients with a diffuse and rather symmetrical cortical abnormality.
Brain malformations are associated with mutations in the beta-tubulin (show TUBB Proteins) gene TUBB2B, supporting its critical role in migration/organization and axon guidance processes.
TUBB2B is required for neuronal migration two disease-associated mutations lead to impaired formation of tubulin (show TUBB Proteins) heterodimers.

TUBB2B Protein Profile

Protein Summary

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria.

Alternative names and synonyms associated with TUBB2B

tubulin, beta 2B class IIb (TUBB2B)
tubulin, beta 2B class IIB (Tubb2b)
tubulin, beta 2B class IIb (Tubb2b)
tubulin beta 2B class IIb (TUBB2B)
tubulin beta 2B class IIb (tubb2b)
hypothetical protein (MW1385)
tubulin beta 2B class IIb S homeolog (tubb2b.S)
tubulin, beta 2b (tubb2b)
tubulin beta-2A chain (LOC101122734)

2410129E14Rik protein
bA506K6.1 protein
fb40f09 protein
N-Tub protein
n-tubulin protein
NBT protein
NST protein
ntubulin protein
PMGYSA protein
RGD1309427 protein
TUBB protein
TUBB2 protein
TUBB2A protein
TUBB2B protein
tubb2c protein
wu:fb40f09 protein
Xn-tubulin protein
zgc:123194 protein

Protein level used designations for Tubulin, beta 2B Proteins (TUBB2B)

, , , , , , , , , , , , , , , , , , tubulin beta-2B chain tubulin, beta 2A class IIa tubulin, beta polypeptide beta-tubulin T beta15 (aa 1-445) t beta-15 tubulin, beta 2 class II beta-tubulin isotype class IIb beta-tubulin tubulin, beta polypeptide paralog neural beta-tubulin tubb-paralog beta-tubulin class-II tubulin beta-2 chain tubulin, beta 2B hypothetical protein beta-2-tubulin tubulin, beta, 2 tubulin beta-2A chain tubulin, beta 2B class IIb

GENE ID	SPECIES
281555	Bos taurus
73710	Mus musculus
291081	Rattus norvegicus
347733	Homo sapiens
394889	Xenopus (Silurana) tropicalis
420883	Gallus gallus
462400	Pan troglodytes
478702	Canis lupus familiaris
1003497	Staphylococcus aureus subsp. aureus MW2
100021036	Monodelphis domestica
379220	Xenopus laevis
641421	Danio rerio
101122734	Ovis aries musimon

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