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Human TUBB3 Protein expressed in HEK-293 Cells - ABIN2734576
Qu, Dwyer, Shao, Yang, Huang, Liu: Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance. in Journal of cell science 2013
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The authors found that transient TUBB3 activation, through ABCB1 (show ABCB1 Proteins), in response to the stimulation of FOXO3a (show FOXO3 Proteins) expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
By linkage and sequencing analyses, we identified the mutation c.784C>T (p.R262C) in TUBB3 gene in six members of a Turkish family with congenital fibrosis of the extraocular muscles.
High TUBB3 expression is associated with Melanoma.
these results identify a broad spectrum of cancers that can at least sporadically express TUBB3. Testing of TUBB3 in cancer types eligible for taxane-based therapies could be helpful to identify patients who might best benefit from this treatment.
TUBB3 overexpression is linked to an aggressive subtype of urinary bladder cancers, which is characterized by increased genetic instability, p53 (show TP53 Proteins) alterations, and rapid cell proliferation.
The central findings of our study are that TSA (show PRDX2 Proteins) and VPA affect the expression of neuronal lineage genes in an rMSCs culture. After exposure to TSA (show PRDX2 Proteins) or VPA, the expression of early neuronal gene decreases but equally the expression of mature neuron genes increases
a positive correlation was observed between Snail (show SNAI1 Proteins) presence and TUBB3 upregulation in tested adenocarcinoma cell lines.
This elucidates a hitherto unknown role for this microtubule protein and provides insight into correlations between high betaIII-tubulin expression and poor patient outcome in this disease
TUBB3 involvement in breast cancer cells apoptosis
The expressions of TYMS (show TYMS Proteins), TUBB3 and STMN1 (show STMN1 Proteins) were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM (show ODZ1 Proteins) staging in patients with gastric cancer.
Here, we report that dissociation of UNC5C (show Unc5c Proteins) and polymerized TUBB3, the highly dynamic beta-tubulin (show TUBB Proteins) isoform in neurons, is essential for netrin-1 (show NTN1 Proteins)/UNC5C (show Unc5c Proteins)-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (show NEU2 Proteins) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Tubb3 could be regulated by both Akt (show AKT1 Proteins) and Erk (show EPHB2 Proteins) pathways.
It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K (show CIT Proteins) in counteracting this event.
Results suggest that down syndrome cell adhesion molecule (show DSCAM Proteins) collaborates with deleted in colorectal cancer (show DCC Proteins) to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1 (show NTN1 Proteins)-induced axon branching.
Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Study shows the critical and specific role of Tubb3 on the stereotyped morphological changes and polarization processes that are required for initiating radial migration to the cortical plate.
this study reports that TUBB3, the most dynamic beta-tubulin (show TUBB Proteins) isoform in neurons, directly interacts with the netrin receptor DCC (show DCC Proteins), and that netrin-1 (show NTN1 Proteins) induces this interaction in primary neurons.
Access to a running wheel for 48h induced plastic changes in the expression of astrocyte beta-tubulin (show TUBB Proteins) (III). Expression was increased in the cerebellum while much smaller increases were observed in the other motor regions.
interaction between alpha-syn and beta-III tubulin (show TUBB Proteins) plays an important role in neuronal alpha-syn accumulation in an multiple system atrophy mouse model.
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
, beta-tubulin 3
, tubulin, beta 3
, tubulin beta-3 chain
, beta3 tubulin
, beta-tubulin class-IV
, tubulin, beta, 3
, tubulin, beta, 4
, class III beta-tubulin
, tubulin beta-4 chain
, tubulin beta-III
, neuron-specific class III beta-tubulin
, tubulin beta-4A chain
, tubulin, beta 4