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anti-Human TUBG1 Antibodies:
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All Species Monoclonal TUBG1 Primary Antibody for ICC, WB - ABIN302067
Haren, Remy, Bazin, Callebaut, Wright, Merdes: NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. in The Journal of cell biology 2006
Show all 13 Pubmed References
Human Polyclonal TUBG1 Primary Antibody for IF, IHC (p) - ABIN4620380
Solc, Baran, Mayer, Bohmova, Panenkova-Havlova, Saskova, Schultz, Motlik: Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo. in Biology of reproduction 2012
Show all 5 Pubmed References
Human Monoclonal TUBG1 Primary Antibody for IF, WB - ABIN535299
Ng, Bertrand, Sullivan, Ethier, Wang, Yergey, Belley, Trimble, Bateman, Alder, Smith, McKernan, Metters, ONeill, Lacaille, Hébert: Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. in Molecular pharmacology 2001
Show all 3 Pubmed References
Chicken Polyclonal TUBG1 Primary Antibody for ICC, IF - ABIN265871
Heckler, Zeleke, Divekar, Fernandez, Tiek, Woodrick, Farzanegan, Roy, Üren, Mueller, Riggins: Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. in Oncotarget 2016
Human Monoclonal TUBG1 Primary Antibody for ICC, IF - ABIN409958
Geoghegan, Buckland, Rogers, Khalifa, OConnor, Rooney, Behnam-Motlagh, Nilsson, Grankvist, Porter: Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells. in Oncotarget 2017
Chicken Monoclonal TUBG1 Primary Antibody for ICC, IF - ABIN269202
Choi, Ryu, Bae, Park, Nam, Kim, Jeong: Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. in International journal of molecular sciences 2018
Data present two patients with novel de novo tubulin gamma 1 (TUBG1) mutations with milder neurodevelopmental disorders.
Study investigated the consequences of four human malformations of cortical development-related TUBG1 variants by using in utero electroporation and a knock-in Tubg1Y92C/+ mouse model and show that pathogenic TUBG1 variants affect neuronal positioning by disrupting neuronal migration and affecting microtubule dynamics rather than centrosomal positioning or nucleation ability.
Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced non-small cell lung cancer stages
Four novel heterozygous variants in TUBG1 were identified in patients with malformations of cortical development.
induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility.
CCT actively promotes the formation of conformationally different aggregates of gamma-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-gamma-tubulin interactions.
that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons
All GCPs are incorporated into the helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains mediate longitudinal interactions with gamma-tubulin.
While binding to gamma-tubulin may help target APC to the site of microtubule nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize microtubule growth.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Results show that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin for its degradation.
In this study, the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex were elucidated by making extensive use of molecular mechanics and molecular dynamics techniques.
Gamma tubulin expression was associated with patients' age, astrocytoma grade, respectability, patient survival and performance. These factors may be important prognostic indicators for patients with astrocytomas.
Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.
Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.
Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer
overexpression of Cdk1 or BRCA1 greatly expands the gamma-tubulin coating of microtubules, suggesting that the microtubule-bound gamma-tubulin is involved in DNA damage response.
in transformed as well as in non-transformed interphase mammalian cells gamma-tubulin is present not only in cytoplasm but also in nuclei and nucleoli where it can be translocated during mitosis
These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly.
The data presented here indicate that gamma-tubulin has a profound relationship with actin filament dynamics
MPK6 phosphorylates EB1c, but not EB1a, and has a role in maintaining regular planes of cell division under stress conditions.
Data show that depletion of either gamma-tubulin or XMAP215 was partially rescued by adding back XMAP215, but not by adding any of the other factors.
Authors report that the only viral nonstructural protein able to reproduce the loss of gamma-tubulin from the microtubule organizing center and the loss of integrity of the microtubule system is Foot-and-mouth disease virus 3C(pro).
Fodrin is a regulatory transporter of gamma-tubulin to the centrosomes for normal progression of mitosis.
Data suggest that localization of Tubg1 (and Plk1 [polo-like kinase 1]) to spindle poles during oocyte meiotic maturation/oogenesis (metaphase I/II) requires participation of Uchl5ip/Haus7 (HAUS augmin-like complex subunit 7).
a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome
Gamma-tubulin is a key regulator of asymmetric cytokinesis in mouse oocytes.
pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin, and plays a role in meiotic spindle organization in oocytes
Results suggest that Fyn and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities.
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin.
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
, gamma-tubulin complex component 1
, tubulin gamma-1 chain
, tubulin, gamma polypeptide
, Tubulin gamma-3 chain
, gamma tubulin