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anti-Human Abcd2 Antibodies:
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The functional integrity of ABCD2 may play an important role in OA pathogenesis via the accumulation of VLCFAs and stimulation of apoptotic death through altering profiles of miRNAs that target ACSL4.
ABCD1 and ABCD2 are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 is involved in the transport of branched chain acyl-CoA into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 from lysosomes into the cytosol.
13-cis-retinoic acid induces ABCD2 expression in human monocytes/macrophages.
ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack
results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA
The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin and TCF-4.
HsABCD1 and HsABCD2 have distinct substrate specificities
LXRalpha is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha binding sites
Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.
These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy.
LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19. This interaction is mediated by amino acids 1-218 of ALDRP.
ALDRP interacts with PMP70. This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 C-terminus [338-659]. This interaction was demonstrated using human PMP70 and mouse ALDRP.
ALDRP interacts with PEX19 splice variants PEX19-delta-E2 and PEX19-delta-E8.
ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice
analysis of D2 localization and the proteome of D2-containing organelles, in adipose tissue
The absence of ABCD2 altered expression of gene clusters associated with lipid metabolism, including PPARalpha signaling.
an essential role for D2 in the protection from dietary erucic acid
ABCD2 is a sterol regulatory element binding protein target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.
Evidence against the adrenoleukodystrophy-related gene acting as a modifier of X-adrenoleukodystrophy.
Abcd1 and Abcd2 gene silencing sensitizes astrocytes for inflammation and may have a role in X-adrenoleukodystrophy
ABCD2 plays a role in th degradation of long-chain saturated and omega9-monounsaturated fatty acids and in the synthesis of docosahexanoic acid.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown\; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
ATP-binding cassette, sub-family D, member 2
, ATP-binding cassette, sub-family D (ALD), member 2
, ATP-binding cassette sub-family D member 2
, ATP-binding cassette sub-family D member 2-like
, adrenoleukodystrophy-like 1
, adrenoleukodystrophy-related protein
, adrenoleukodystrophy related