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The RXR agonist methoprene acid worked as well as all-trans-retinoic acid at increasing both lysosomal phospholipase A2 mRNA and enzyme activity
analyzed the association of five polymorphisms (-1357G>A, -403T>C, Arg92His, Ile198Thr, Ala379Val) and related haplotypes at the PLA2G7 (show Lp-PLA2 Proteins) locus with angiographic coronary artery disease, plasma LpPLA2 activity, and long-term survival
Patients with transient ischemic atack have a high-risk mechanism (large vessel stenosis or cardioembolism) or will experience stroke/death within 90 days. In contrast to CRP (show CRP Proteins), both Lp-PLA(2 (show Lp-PLA2 Proteins)) mass and activity were associated with this composite end point.
LPLA2 plays a role in the generation of CD1d (show CD1D Proteins) complexes with thymic lipids required for the normal selection and maturation of iNKT cells.
LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages
identification of the catalytic triad and the role of cysteine residues in lysosomal phospholipase A2
Lpla2 has broad positional specificity for the sn-1 (show HNRNPU Proteins) and sn-2 acyl groups in phosphatidylcholine (show SGMS2 Proteins) and phosphatidylethanolamine
A deficiency of lysosomal phospholipase A2 results in foam cell formation, surfactant lipid accumulation, splenomegaly, and phospholipidosis in mice.
The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.
, lysophospholipase 3 (lysosomal phospholipase A2)
, group XV phospholipase A2
, 1-O-acylceramide synthase
, LCAT-like lysophospholipase
, lysosomal phospholipase A2