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the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC, is reported.
Results showed that the variants rs11191979, rs2164624 and rs4925 of GSTO1 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.
Significant correlation between severities of skin manifestations with GSTO1 polymorphism status in arsenic-exposed population of India.
GSTO1*C is linked to the pre-stage of Alzheimer's disease; rs4925 could be a genetic marker for cognitive impairment
This study demonstrated that Distribution of the GSTO1 alleles and genotypes was nearly equal between the control group and SCA2 patients. GSTO1 genotypes were not associated to clinical markers in SCA2 patients.
GSTO1 genetic polymorphisms are associated with the progression of HBV infection.
GSTP1 and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity.
No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 N142D polymorphisms.
The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene.
Our results indicate that GSTO1*C/GSTO2*G haplotype is associated with increased risk of TCC. The modifying effect of GSTO2*G/G genotype on individual susceptibility to TCC is more pronounced, when associated with smoking.
This meta-analysis demonstrates that GSTO2 polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.
Our study is the first to show that the frequency of GSTO1 A140D gene polymorphism in the Turkish population is similar to other Caucasian populations and that this polymorphism is not associated with susceptibility to NSCLC.
Overexpression of GSTO1 is associated with esophageal squamous cell carcinoma.
GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.
Genetic variants in GSTO1 are associated with increased risk for recurrent miscarriage.
The common A140D genetic polymorphism in GSTO1 was found to have significant effects on the kinetics of both the deglutathionylation and glutathionylation reactions.
The frequencies of GSTO1 and GSTO2 genotypes were not significantly different between head and neck squamous cell carcinoma cases and controls.
Single nucleotide polymorphisms (SNPs) in arsenic methyltransferase and methylene-tetrahydrofolate reductase is associated with bladder cancer in those exposed to low concentrations of inorganic arsenic. SNPs in glutathione S-transferase omega-1 are not.
GSTO-1 plays a key role in hormesis induced by low dose trichloroethylene.
Our studies confirm the lack of association between GSTO1 variants and essential hypertension risk, also for two uncommon genetic variants with large functional effects in italian patients.
Data indicate that GSTO1-1 is required for LPS-mediated signalling in macrophages and that it acts early in the LPS-TLR4 pro-inflammatory pathway.
shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.
glutathione S-transferase omega-1
, glutathione transferase omega-1
, glutathione S-transferase omega 1
, glutathione-S-transferase omega 1
, glutathione S-transferase O1
, GSTO 1-1
, MMA(V) reductase
, S-(Phenacyl)glutathione reductase
, glutathione S-transferase omega 1-1
, glutathione-dependent dehydroascorbate reductase
, monomethylarsonic acid reductase
, glutathione-S-transferase like
, Glutathione transferase omega 1 (GSTO 1-1) (p28)
, glutathione S-transferase like