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Results showed that the variants rs11191979, rs2164624 and rs4925 of GSTO1 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.
Significant correlation between severities of skin manifestations with GSTO1 polymorphism status in arsenic-exposed population of India.
GSTO1*C is linked to the pre-stage of Alzheimer's disease; rs4925 could be a genetic marker for cognitive impairment
This study demonstrated that Distribution of the GSTO1 alleles and genotypes was nearly equal between the control group and SCA2 (show LY6E Proteins) patients. GSTO1 genotypes were not associated to clinical markers in SCA2 (show LY6E Proteins) patients.
GSTO1 genetic polymorphisms are associated with the progression of HBV infection.
GSTP1 (show GSTP1 Proteins) and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity.
No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 (show GSTO2 Proteins) N142D polymorphisms.
The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene.
Our results indicate that GSTO1*C/GSTO2 (show GSTO2 Proteins)*G haplotype is associated with increased risk of TCC (show SFXN1 Proteins). The modifying effect of GSTO2 (show GSTO2 Proteins)*G/G genotype on individual susceptibility to TCC (show SFXN1 Proteins) is more pronounced, when associated with smoking.
This meta-analysis demonstrates that GSTO2 (show GSTO2 Proteins) polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.
Data indicate that GSTO1-1 is required for LPS (show TLR4 Proteins)-mediated signalling in macrophages and that it acts early in the LPS-TLR4 (show TLR4 Proteins) pro-inflammatory pathway.
shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 (show NOX3 Proteins) and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
Genes encoding the antioxidants GPX2 (show GPX2 Proteins) and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.
glutathione S-transferase omega-1
, glutathione transferase omega-1
, glutathione S-transferase omega 1
, glutathione-S-transferase omega 1
, glutathione S-transferase O1
, GSTO 1-1
, MMA(V) reductase
, S-(Phenacyl)glutathione reductase
, glutathione S-transferase omega 1-1
, glutathione-dependent dehydroascorbate reductase
, monomethylarsonic acid reductase
, glutathione-S-transferase like
, Glutathione transferase omega 1 (GSTO 1-1) (p28)
, glutathione S-transferase like