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RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.
RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect.
Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity.
The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23.
elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced
gene structure and transcription regulation
GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling
Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation.
Notch signaling positively regulates phosphorylation of Akt, possibly via phosphorylation of RGS19
RGS19 and its partner Galpha-inhibiting activity polypeptide 3 (GNAI3) are involved in zVAD-, but not TNF-, induced cell death.
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3, or RGS19; or had been treated with pertussis toxin, were similar to controls
Rgs19 plays important roles in palatal fusion.
Regulator of G protein signaling 19 enhances cell proliferation through binding to GAIP-interacting protein C-terminus.
RGS19 influenced cardiac development and had negative effects on heart function.
RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference
Results suggest a complex role for RGS19 in regulating the ability of Wnt3a to signal to the level of beta-catenin and gene transcription.
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
regulator of G-protein signaling 19
, regulator of G-protein signalling 19
, G alpha interacting protein
, G protein signalling regulator 19
, G-alpha-interacting protein
, guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
, G-alpha interacting protein
, calcium/calmodulin-dependent protein kinase I