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Data suggest that Gpr176 (G-protein coupled receptor 176 (show GPR176 Proteins)) is an SCN (show SRI Proteins)-(suprachiasmatic nucleus-)enriched orphan GPCR (show NMUR1 Proteins) (G-protein-coupled receptor (show ADRA1A Proteins)) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176 (show GPR176 Proteins). [REVIEW]
These results suggest that the expression of RGS20 may promote metastasis of tumor cells.
Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC).
provide new evidence that RGSZ1 interacts not only with Galpha (show SUCLG1 Proteins)(z,) but also with Galpha (show SUCLG1 Proteins)(i), as supported by in vitro binding assays and functional studies
The major function of PKCI-1 (show HINT1 Proteins) is to modulate mu opioid receptor (show OPRM1 Proteins) signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway
Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 (show STMN2 Proteins) effectively blocked the ability of SCG10 (show STMN2 Proteins) to induce microtubule disassembly
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, gz-selective GTPase-activating protein
, regulator of G-protein signaling 20 variant 2
, regulator of G-protein signaling Z1
, regulator of G-protein signalling 20
, regulator of Gz-selective protein signaling 1
, Gz-selective GTPase-activating protein
, Gz-specific GAP
, RGS protein Gz-GAP
, retina-specific regulator of G-protein signaling 1