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Human Polyclonal SGCB Primary Antibody for IHC, IHC (p) - ABIN4284180
Pozsgai, Griffin, Heller, Mendell, Rodino-Klapac: β-Sarcoglycan gene transfer decreases fibrosis and restores force in LGMD2E mice. in Gene therapy 2016
Show all 3 Pubmed References
Clinical severity of limb-girdle muscular dystrophy type 2Emay be predicted by SGCB gene mutation and sarcoglycan (show SGCD Antibodies) protein expression.
Defective assembly of sarcoglycan (show SGCD Antibodies) complex in patients with beta-sarcoglycan gene mutations
beta-sarcoglycan and SPATA18 (show SPATA18 Antibodies) may have a role in limb-girdle muscular dystrophy type 2E
While the quantity of beta-sarcoglycan was nearly normal (show EEF1G Antibodies) in the limb girdle muscular dystrophy (LGMD)2E carrier, the levels of dysferlin (show DYSF Antibodies) protein were reduced to 50% of controls in the carriers of LGMD2B (show DYSF Antibodies).
These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan (show SGCD Antibodies) subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan (show SGCD Antibodies) transport.
The limb-girdle muscular dystrophy patients with beta-sarcoglycan deficient LGMD2E do not enable an accurate prediction of the genotype.
beta-Sarcoglycan deficiency reduces atherosclerotic plaque formation in ApoE (show APOE Antibodies)-knockout mouse model.
In Sgcb-null mice, severe morphological disruption was present from 4 weeks in both quadriceps and diaphragm, and included conspicuous deposition of extracellular matrix components.
Aging leads to changes in expression of beta-sarcoglycan in aged affected muscles (diaphragm and limb).
Sarcoglycan beta missense mutations affect sarcoglycan (show SGCD Antibodies) complex assembly and/or localization to the cell surface and provide information on the molecular mechanisms underlying the effects of various sarcoglycan (show SGCD Antibodies) mutations in muscular dystrophies.
Data demonstrate a novel function of the sarcoglycan (show SGCD Antibodies) complex in whole body glucose homeostasis and skeletal muscle metabolism, suggesting that the impairment of the skeletal muscle metabolism influences the pathogenesis of muscular dystrophy.
subcellular localization of dScgbeta dramatically changes during mitosis through possible association with tubulin (show TUBB Antibodies); these observations point to a complex role of sarcoglycans in non-muscle tissues.
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.
43 kDa dystrophin-associated glycoprotein
, beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
, limb girdle muscular dystrophy 2E (non-linked families)
, sarcoglycan, beta (43kD dystrophin-associated glycoprotein)
, sarcoglycan beta
, SarcoGlycaN family member (sgn-1)