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anti-Human YWHAG1 Antibodies:
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Chicken Monoclonal YWHAG1 Primary Antibody for ICC, IF - ABIN151870
Hu, Addlagatta, Lu, Matthews, Liu: Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 8 Pubmed References
Overexpression of 14-3-3gamma in uterine leiomyoma cells resulted in reductions in the phosphorylations of multiple signaling molecules, including AKT, pan, ERK1/2, GSK-3 alpha/beta, MEK1/2, Foxo1 and Vimentin and may have causal effect of the growth of uterine leiomyoma.
14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis.
14-3-3gamma protein directly interacts with the kinase domain of CaMKK2 and the region containing the inhibitory phosphorylation site Thr(145) within the N-terminal extension. CaMKK isoforms differ in their 14-3-3-mediated regulations and the interaction between 14-3-3 protein and the N-terminal 14-3-3-binding motif of CaMKK2 might be stabilized by small-molecule compounds.
Findings indicate the roles and molecular mechanisms of 14-3-3GAMMA protein (14-3-3gamma) in epithelial-mesenchymal transition (EMT), migration, and neoplasm invasion.
Study demonstrated a mechanism by which 14-3-3gamma restricts centrosome duplication to once per cell cycle, by inhibiting cdc25C and cdk1 activation resulting in decrease phosphorylation of T199 in NPM1. Also, loss of 14-3-3gamma causes centrosome over-duplication, centrosome clustering and tumor formation in mice.
Study identified 14-3-3gamma as a binding partner for segment a of ANO1 and enhanced the surface expression of ANO1. In addition, its gene silencing of 14-3-3gamma inhibited migration and invasion of these glioblastoma cell lines.
These results suggest that a major role of 14-3-3gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation.
hypermethylation of the 14-3-3 gene promoter accounts for the decreased 14-3-3 gamma in uterine leiomyomas and that such a low level of expression may be involved in the pathogenesis of leiomyomas
MiR-217 directly targeted 3'UTR of YWHAG and suppressed the expression of YWHAG.
Data indicate angiopoietin-like 4 (ANGPTL4) as a key player that coordinates an increase in cellular energy flux crucial for EMT via an ANGPTL4/14-3-3gamma signaling axis.
14-3-3gamma regulates the differentiation ability of CPNE1 through the binding with C2A domain of CPNE1 in HiB5 cells.
YWHAG de novo mutations cause early onset epilepsy, including epileptic encephalopathies and intellectual disability.
Study found that the overexpression of 14-3-3gamma in utero in the developing mouse cortex results in delays in pyramidal neuron migration.
The present study revealed the tumor suppressive role of miR-509-5p in non-small cell lung cancer (NSCLC) by targeting YWHAG, suggesting that miR-509-5p/YWHAG axis might be considered as a novel and potential target for clinical diagnosis and therapeutics of NSCLC.
14-3-3 protein expression was quantitatively analyzed in cerebrospinal fluid of 231 sporadic Creutzfeldt-Jakob disease and 2035 control patients.
Data suggest that miR-181b-3p functions as a metastasis activator by promoting Snail-induced epithelial-mesenchymal transition in breast cancer cells by directly targeting YWHAG.
Loss of p53 function may result in upregulation of 14-3-3gamma in lung cancers
Changes for CRMP2, TCP1epsilon, TPM2 and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs.
These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding.
Proteomics analysis show that Ser40 of TH protein does not significantly contribute to the binding of 14-3-3gamma, and rather has reduced accessibility in the TH:14-3-3gamma complex.
molecular network including eIF1AX, RPS7, and 14-3-3gamma regulates protein translation and cell proliferation in BMECs.
14-3-3gamma promotes surface expression of Best1 channel in astrocytes through direct interaction.
This study found that in utero 14-3-3gamma-deficiency resulted in delays in neuronal migration as well as morphological defects.
Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two.
Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamm occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization.
hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3gamma pathway.
Data show that binding motifs of 14-3-3gamma were identified in components of the transduceosome, including STAR.
overexpression of 14-3-3gamma led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins.
a new role for 14-3-3gamma in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53.
Studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation.
Data suggest that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease.
The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes
Nuclear poly-ADP-ribosylation of 14-3-3gamma was completely inhibited by the dose of the PARP-1 inhibitor 5-iodo-6-amino-1,2-benzopyrone that produced profound memory disturbances in maze learning tests
the binding of 14-3-3gamma to Raf indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Data suggest that neuroglobin contributes to neuronal defensive machinery against oxidative injuries by regulating 14-3-3gamma expression.
When zebrafish ywhag1 was knocked down, reduced brain size and increased diameter of the heart tube were observed, indicating that the infantile spasms and cardiomegaly seen in the patient with the telomeric deletion
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
, 14-3-3 protein gamma
, protein kinase C inhibitor protein 1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
, scavenger receptor cysteine rich domain containing, group B (4 domains)
, 14-3-3 protein gamma-A
, 14-3-3 protein gamma-subtype
, 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide
, tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma
, tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide
, tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide
, 14-3-3 protein gamma subtype
, 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide
, 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
, 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
, 14-3-3 protein gamma-1