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Human AMH Protein expressed in HEK-293 Cells - ABIN2714759
Signorile, Petraglia, Baldi: Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells. in Journal of experimental & clinical cancer research : CR 2014
Gdf9 (show GDF9 Proteins) significantly suppressed the expression of amh while increased that of activin beta subunits (inhbaa (show INHBA Proteins) and inhbb (show INHBB Proteins)) in vitro.
These data suggest that an important aspect of Fsh (show BRD2 Proteins) bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3.
amh controls the balance between proliferation and differentiation of male germ cells.
nuclear receptor subfamily 5, group A, member 1b is a new candidate for sex determination and differentiation in a way similar to steroidogenic factor 1 (show NR5A1 Proteins), possibly involving AMH
zebrafish Anti-Mullerian hormone (Amh) is regulated by sox9a, sox9b, and cyp19a1a during gonad development
amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.
It was shown that the male-to-female sex reversal phenotype in hotei medaka mutants is not a direct consequence of anti-Mullerian hormone signaling in supporting cells, but is instead mediated by germ cells.
Data suggest that serum levels of AMH are down-regulated during second half of gestation in (1) women with gestational diabetes, (2) pregnant women with type 2 diabetes, and (3) control pregnant women. A positive association between AMH and testosterone levels was observed in all groups. Also, serum AMH levels are negatively associated with maternal age in the population studied.
Data confirm that serum levels of AMH decline as function of age (not menstrual cycle) in women ages 20-50; here, results of ELISA assays of serum levels of AMH vary according to kit used. These studies were conducted at a fertility clinic in Poland; serum AMH is proposed as biomarker for ovarian reserve.
AMH single nucleotide polymorphism is associated with Endometriosis-associated infertility.
This study demonstrated the existence of an AMH-FOXL2 (show FOXL2 Proteins) relationship in hGCs. AMH is capable of increasing both gene and protein expression of FOXL2 (show FOXL2 Proteins). Because FOXL2 (show FOXL2 Proteins) induces AMH transcription, these ovarian factors could be finely regulated by a positive feedback loop mechanism to preserve the ovarian follicle reserve.
Data suggest that circulating AMH influences development of human brain; high levels of circulating AMH are unique to developing boys; here, boys age 5-6 years exhibit up-regulation of circulating AMH but are delayed in maturity index (judged by drawings) as compared to girls age 5-6 years. This study was conducted in New Zealand.
The combination of GDF9 (show GDF9 Proteins) + BMP15 (show BMP15 Proteins) potently stimulates AMH expression in primary cumulus cells.
Surface plasmon resonance analysis showed no significant association between FS288 and AMHC (show MYH6 Proteins) , suggesting that FS288 indirectly regulates AMH signaling. Activin A (show INHBA Proteins), a direct target of FS288, did not itself induce reporter activity in P19 (show CDKN2D Proteins) cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A (show INHBA Proteins) may influence the response of some cell types to AMH.
The current study showed no significant difference in AMH level between Sudanese women with preeclampsia and the controls. AMH level was not associated with age, parity, gestational and body mass index.
In a 46,XY phenotypically female patient bearing testes in inguinal canal, and diagnosed with complete androgen insensitivity syndrome, the dysfunctioning of AR by mutation enhanced AMH expression which ultimately leads to the failure in maturation of Sertoli cells.
These findings underscore the importance of screening young females with AMH for possible occult primary ovarian insufficiency.
AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons.
AMH and FOXL2 (show FOXL2 Proteins) collaboratively work to reserve ovarian follicles. AMH is an endogenous target gene of FOXL2 (show FOXL2 Proteins).
Up-regulation of SOX9 (show SOX9 Proteins) in sertoli cells from testiculopathic patients accounts for increasing anti-mullerian hormone expression via impaired androgen receptor (show AR Proteins) signaling.
Male mice require AMH to undergo normal social development.
Data show that Purkinje cells express receptors for Mullerian inhibiting substance (MIS), and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum.
MIS may be involved in anterograde rather than autocrine or retrograde regulation of neurons.
FSH (show BRD2 Proteins) and cAMP stimulate AMH transcription by granulosa cells. FSH (show BRD2 Proteins) and LH have an additive effect, which may be important in polycystic ovary syndrome.
This suggests that MIS is one of the determinants of "boy"-specific behavior.
Role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function.
Anti-Mullerian hormone inhibits activation and growth of bovine ovarian follicles in vitro and is localized to growing follicles.
This study showed that antral follicle counts (AFC) and AMH levels were repeatable when determined at an unknown stage of follicular growth and expected day of follicular wave emergence, but repeatability was greater for AMH than AFC.
The effects of castration and other surgical intervention on the blood levels of anti-Muellerian hormone, inhibin A (show INHA Proteins), gonadotropins, and gonadotropin receptors in bull calves are reported.
Results from these studies indicate that AMH signaling plays a role in both regulating granulosa cell proliferation and preventing granulosa cells from 5- to 8-mm follicles from undergoing premature differentiation before follicle selection.
These findings indicate the followings: AMH mRNA levels decrease in both dominant and secondary follicles during follicular deviation; granulosa cells from heathy follicles express more AMH mRNA compared to subordinate follicles undergoing atresia and FSH (show BRD2 Proteins) stimulates AMH and AMHR2 (show AMHR2 Proteins) mRNA expression in granulosa cells of co-dominant follicles.
Measurement of AMH concentration in the plasma of cows can help to predict their capacity for embryo production in response to gonadotrophin treatment.
In first study to investigate the blood profile and immunohuistochemistry of anti-Mullerian hormone in bovine granulosa-theca cell tumors, the findings indicated that anti-Mullerian hormone is a novel biomarker for granulosa-theca cell tumors in cattle.
Regulation of anti-Mullerian hormone production in the cow.
Intrafollicular AMH was not a marker of cystic development in the cow, but low AMH concentrations in cysts were associated with luteinization.
AMH expression is modulated by androgens in bovine granulosa cells from small follicles.
Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome.
, anti-Mullerian hormone
, anti-mullerian hormone
, Mullerian inhibiting factor
, Mullerian inhibiting substance
, anti-Muellerian hormone
, muellerian-inhibiting substance
, Mullerian inhibitory substance
, Anti - Mullerian hormone (Mulerian inhibiting substance)