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Human Monoclonal Follistatin Primary Antibody for IHC (p), ELISA - ABIN2473681
Holst, Holstein: [Sociomedical survey among the elderly in 10 EEC countries. An analysis based on non-respondents to a questionnaire survey of the population 70-95 years of age living in 4 Danish communities]. in Ugeskrift for laeger 1990
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Human Polyclonal Follistatin Primary Antibody for ELISA, WB - ABIN2473679
Lin, Morrison, Phillips, de Kretser: Regulation of ovarian function by the TGF-beta superfamily and follistatin. in Reproduction (Cambridge, England) 2003
Human Monoclonal Follistatin Primary Antibody for IHC (p), ELISA - ABIN2473680
Majdic, McNeilly, Sharpe, Evans, Groome, Saunders: Testicular expression of inhibin and activin subunits and follistatin in the rat and human fetus and neonate and during postnatal development in the rat. in Endocrinology 1997
Show all 4 Pubmed References
FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
Surface plasmon resonance analysis showed no significant association between FS288 and AMHC (show MYH6 Antibodies) , suggesting that FS288 indirectly regulates AMH (show AMH Antibodies) signaling. Activin A (show INHBA Antibodies), a direct target of FS288, did not itself induce reporter activity in P19 (show CDKN2D Antibodies) cells, but did prevent the FS288-induced increase in AMH (show AMH Antibodies) signaling. Hence, local concentrations of FS288 and Activin A (show INHBA Antibodies) may influence the response of some cell types to AMH (show AMH Antibodies).
results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer
These data indicate that FST is a bona fide metastasis suppressor in this mouse model and support future efforts to develop an FST mimetic to suppress metastatic progression.
These findings indicate that muscle-specific (show EIF3K Antibodies) Fst overexpression in pigs enhances skeletal muscle growth, at least partly due to myofiber hypertrophy and providing a promising approach to increase muscle mass in pigs and other livestock.
High follistatin expression is associated with lung adenocarcinoma.
FST and KLK6 (show KLK1 Antibodies) may have significance in breast cancer detection
Follistatin and activin A (show INHBA Antibodies) are higher in MI than in CAD (show CAD Antibodies) suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB
The activin-A (show INHBA Antibodies) to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.
Low follistatin expression is associated with liver cirrhosis.
Follistatin levels are associated with circulating leptin (show LEP Antibodies) levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.
Response to selection for increased litter size could not be attributed to effects at the estrogen receptor (show ESR1 Antibodies), retinol-binding protein or follistatin loci.
Data suggest that SMAD4 (SMAD family member 4 (show SMAD4 Antibodies)) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 (show SMAD4 Antibodies) dependent.
The expression of the components of the activin (show Actbeta Antibodies)-inhibin-follistatin system is altered in bovine cystic ovarian disease.
A functional role for oocyte-derived follistatin in bovine early embryogenesis.
Uterine Fst-cKO mice demonstrate severe fertility defects and deliver only 2% of the number of pups delivered by control females. In Fst-cKO mice, the uterine luminal epithelium does not respond properly to estrogen and progesterone signals and remains unreceptive to embryo attachment by continuing to proliferate and failing to differentiate.
Data suggest that the level of circulating follistatin is involved in testicular damage due to autoimmune orchitis; these studies were conducted using gene transfer to increase circulating levels of follistatin in experimental model of autoimmune orchitis.
Hypergravity affects follistatin levels in muscle through the vestibular system in mice. Follistatin may play some roles in the interactions between muscle and bone metabolism in response to gravity change.
Fst promotes brown adipocyte characteristics in both white adipose tissue and brown adipose tissue depots in vivo through distinct mechanisms.
Results showed activin (show Actbeta Antibodies)-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin (show Actbeta Antibodies)-C. Study provides evidence to support a role of activin (show Actbeta Antibodies)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function.
OVOL1 (show OVOL1 Antibodies)-regulated Fst and SFRP1 (show SFRP1 Antibodies) affect hair inductive potency of neonatal dermal cells.
This study assesses the regulation of activin A (show INHBA Antibodies) and follistatin in a murine myocardial ischaemia-reperfusion model.
Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.
Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.
fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
, follistatin 1
, activin-binding protein
, follistatin isoform FST317
, follistatin A