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Raynaud's phenomenon is associated with variation in gene NOS1
Based on a quantitative comparison of their dendritic characteristics, the NOS1 neurons of humans and rats displayed a statistically significant difference
The neuronal NOS exon 7 in the experimental group has a higher ratio of G/T and T/T genotypes than the control group, and also that the neuronal NOS intron 4 in the experimental group has a significantly higher a/b genotype than the control group. This suggests that the neuronal NOS gene mutation could be related to the development of osteonecrosis of the femoral head.
High NOS1 expression is associated with Dilated Hearts.
NOS1-ex1f VNTR is associated with white matter microstructure in females with ADHD and healthy females.
selected nNOS polymorphisms do not significantly contribute to Parkinson's disease risk in north Indian population.
Lysophosphatidylcholine induced nNOS uncoupling and nNOS(Ser852) phosphorylation, reduced NO and H2O2 production and improved superoxide production by modulating ERK1/2 activity in endothelial cells.
NOS1 (missense variant rs79487279) was associated with bipolar disorder.
Data suggest that NOS1 and NOS2 play roles in stress-induced surge in nitric oxide (NO) production; NO serves as mediator for development of secondary neurological disorders associated with stress such as anxiety and anxiety disorders. [REVIEW]
nNOS mediates the human coronary vasodilator response to mental stress, predominantly through actions at the level of coronary resistance vessels.
High sodium activation of collecting duct nitric oxide synthase 1beta signaling induces suppression of systemic and intrarenal renin-angiotensin-aldosterone system, thereby modulating epithelial sodium channel and other sodium transporter abundance and activity to maintain sodium homeostasis.
This immunohistochemical study provides detailed and novel information about the spatial and temporal distribution of nNOS and ERalpha (show ESR1 Proteins) in the female mouse hypothalamus. In addition, it reveals critical sites in which nNOS expression changes during postnatal development, and identifies distinct subsets of hypothalamic nNOS neurons according to their neurochemical phenotype.
nNOS mediates insulin (show INS Proteins)- and oxidative stress-induced (show SQSTM1 Proteins) glucose uptake in skeletal muscle myotubes.
HIV-1 Tat (show TAT Proteins) causes cognitive deficits and selective loss of parvalbumin (show PVALB Proteins), somatostatin (show SST Proteins), and neuronal nitric oxide synthase expressing hippocampal CA1 (show CA1 Proteins) interneuron subpopulations.
In an animal model of Alzheimer's disease, nNOS dimers are disrupted in the cerebral cortex and may be involved in the decrease of nitric oxide production and the development of Alzheimer's disease.
Immunohistochemical analysis confirmed increased amount of NOS1 protein in neuronal somata and processes in the perilesional cortex in APP (show APP Proteins)/PS1 (show PSEN1 Proteins)-severe traumatic brain injury(TBI) mice compared to APP (show APP Proteins)/PS1 (show PSEN1 Proteins)-sham (p < 0.05) or Wt-sTBI mice (p < 0.01).
Ischemic postconditioning protects the heart against ischemia-reperfusion injury via the NOS1 pathway in the sarcoplasmic reticulum and mitochondria.
To investigate the role of medial ganglionic eminence-(MGE)-derived nNOS(+) interneurons in fear learning, donor MGE cells were transplanted into dentate gyrus of nNOS knock-out (nNOS(-/-)) or wild-type mice. Results showed that the transplantation of MGE cells promoted the acquisition of nNOS(-/-) but not the wild-type mice, suggesting the importance of nNOS(+) neurons in fear acquisition.
aerobic exercise training could improve cardiac systolic function and alleviate LV chamber dilation, cardiac fibrosis and hypertrophy in heart failure mice. The mechanism responsible for the protective effects of aerobic exercise is associated with the activation of the beta3-AR-nNOS-NO pathway.
These findings highlight a key role of the TLR4 (show TLR4 Proteins)-NOS1-AP1 (show JUN Proteins) signaling axis in regulating macrophage polarization
findings indicate that spinal transection affects nNOS and parvalbumin (show PVALB Proteins) in different neuronal circuits
amyloid and oxidative stress-related disease proteins like NOS 1 is increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.
Motoneurons in the ventral horns respond more sensitively to ischemia/reperfusion than do neurons localized in the other spinal cord regions. Changes in cNOS (show NOS3 Proteins) activity may also influence the axonal conductance in the white matter.
Distribution pattern of the enzyme responsible for the synthesis of NO, nitric oxide synthase, in the population of primary afferent neurons of the trigeminal ganglion and mesencephalic trigeminal nucleus of the rabbit.
The regional distribution of nitric oxide synthase activity and neuronal nitric oxide synthase immunoreactivity, measured segment by segment shows that nitric oxide may play a significant role in the stepping cycle in the quadrupeds.
NOS via Nitric oxide production may play a neuroprotective role in ischemic/reperfusion injury.
the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain
NOS1 is a key regulator of motor axon ontogeny in the developing vertebrate spinal cord.
The distribution pattern of nNOS gene expression showed the highest expression levels in the forebrain followed by the optic tectum, the brainstem and the spinal cord, whereas scarce expression was detected in the cerebellum.
glutamate (show GRIN2A Proteins)-induced apoptosis was strongly reversed by nNOS inhibitors and weakly by iNOS (show NOS2 Proteins) inhibitors, thus indicating nNOS involvement in glutamate (show GRIN2A Proteins)-mediated apoptosis.
The expression, localization, and distribution of 3 nitric oxide synthase enzymes through the estrous cycle in bovien fallopian tubes are reported.
Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin (show KRIT1 Proteins) binding, increase FMN (show FMN1 Proteins) shielding, and suppress interflavin electron transfer
This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.
Our results suggest that the presence of low mycotoxin doses in feed slows down the mRNA expression of nitric oxide synthase-1 and nitric oxide synthase-2 genes which probably lowers the concentrations of nitric oxide, a common precursor of inflammation.
nNOS is an important regulator of renal hemodynamics in the newborn kidney, but not in the adult.
Data suggest that pig sperm contain bNOS, iNOS (show NOS2 Proteins), and eNOS (show NOS3 Proteins); up-regulation of NOS by leptin (show LEP Proteins) during acrosome reaction and inhibition of acrosome reaction by inhibitors of nitric oxide synthases suggests these enzymes are involved in acrosome reaction.
Periodic acceleration (pGz) acutely increases endothelial and neuronal nitric oxide synthase expression in endomyocardium of normal swine.
Regional difference in blood flow has no effect on nNOS protein content in different sized conduit arteries.
study concludes that in the cerebral cortex of newborn piglets, the mechanism of hypoxia-induced increased tyrosine phosphorylation of nNOS is mediated by nNOS-derived nitric oxide.
Data suggest that angiotensin II regulates nNOS and eNOS expression and NOS activity in afferent arterioles of the developing kidney via angiotensin 1 and 2 receptors.
form-deprivation myopia upregulates the expression of NMDAR1 (show GRIN1 Proteins) and ncNOS and increases cGMP content in the retina. NMDAR1 (show GRIN1 Proteins)/NO-cGMP pathway may contribute to abnormal visual signals during myopic progression.
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
NOS type I
, constitutive NOS
, neuronal NOS
, nitric oxide synthase, brain
, peptidyl-cysteine S-nitrosylase NOS1
, nitric oxidase synthase
, neuronal nitric oxide synthase
, nitric oxide synthase 1 (neuronal)
, Nitric oxide synthase, brain
, neuronal nitric oxide synthase 1
, nitric oxide synthase 1 L homeolog
, LOW QUALITY PROTEIN: nitric oxide synthase, brain