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except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
UCP2 is a key mediator of hypoxia-triggered chemoresistance in non-small cell lung cancer cells via repression of peroxisome proliferator-activated receptor gamma (show PPARG Proteins).
Results here presented suggest that UCP (show UCP1 Proteins) variability has different pleiotropic effects, by affecting both telomere length and glucose homeostasis, likely through an influence on energy metabolism and stress response
UCP2 expression is associated with weight loss after hypocaloric diet intervention.
Decreased UCP2 gene expression in mononuclear cells from obese and diabetic patients might contribute to the immunological abnormalities in these metabolic disorders and suggests its role as a candidate gene in future studies of obesity and diabetes.
UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.
The data indicate that in the context of hepatocellular carcinoma, miR (show MLXIP Proteins)-214 acts as a putative tumour suppressor by targeting UCP2 and defines a novel mechanism of regulation of UCP2.
UCP2 inhibition triggered cellular apoptosis and autophagy.
The GG genotype of the UCP1 (show UCP1 Proteins)-3826 A/G polymorphism appears to contribute to the onset of childhood obesity in Turkish children. The GG genotype of UCP1 (show UCP1 Proteins), together with the del/del genotype of the UCP2 polymorphism, may increase the risk of obesity with synergistic effects. The ins (show INS Proteins) allele of the UCP2 exon 8 del/ins (show INS Proteins) polymorphism may contribute to low HDL (show HSD11B1 Proteins) cholesterolemia.
Expression of UCP2 and PLIN1 (show PLIN1 Proteins) genes influences the resting metabolic rate in obese individuals and could predict the weight loss after bariatric surgery.
The lack of association with ECG derived QTd and UCP2 DD may suggest that gene-related QRS (show QARS Proteins) duration prolongation is independent of cardiac hypertrophy.
UCP2 regulates embryonic neurogenesis through reactive oxygen species-mediated Yap (show YAP1 Proteins) alternation, thus shedding new sight on mitochondrial metabolism involved in embryonic neurogenesis.
Data demonstrate that UCP2 controls pancreas development through the ROS (show ROS1 Proteins)-AKT (show AKT1 Proteins) signaling pathway.
UCP2 has two glycine-rich motifs, motif 1: EGIRGLWKG (170-178) and a Walker A-like motif 2: EGPRAFYKG (264-272). These motifs seem to be important for the function of UCP2. UCP2/K177E- or UCP2/G174L-expressed cells did not induce enlarged cell shapes. UCP2/K177E and UCP2/G174L produced functional incompetence of the glycine-rich motif 1. Senescent-like cells significantly decreased the mitochondrial membrane potentials.
our findings reveal that UCP2 regulates inflammation responses in astrocytes and plays an important role in the pathogenesis of depression and that UCP2 may be a promising therapeutic target for depression.
These results suggest that Leishmania exploits A20 (show TNFAIP3 Proteins) and UCP2 to impair inflammasome activation for disease propagation
UCP-2 prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E (show APOE Proteins)-knockout mice via antioxidant and antiapoptotic activities.
This study demonstrating a FABP4 (show FABP4 Proteins)-UCP2 axis with the potential to modulate the microglial inflammatory response.
The miR (show MLXIP Proteins)-133a-UCP2 pathway participates in inflammatory bowel disease (IBD) by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.
PPARgamma (show PPARG Proteins) inhibited PDGF (show PDGFA Proteins)-BB-induced ROS (show ROS1 Proteins) in VSMCs by upregulating UCP2 expression.
these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Proteins) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Proteins)) in Angus steers selected to have high or low RFI (show RNF34 Proteins) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial