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except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
UCP2-866 G/A polymorphism is associated with obesity.
Dats suggest that UCP2 levels in peripheral blood mononuclear cells of obese women with low REE (resting energy expenditure) are significantly lower compared to obese women with low REE and compared to normal weight women.
The A/A genotype was found to be an independent marker of good prognosis after adjustment for secondary variables (age, sex, glucose level, NIHSS score at baseline, complete recanalization and early neurological improvement) in a logistic regression analysis. The AA genotype of UCP2-866 may predict a better functional outcome in ischemic stroke after recanalization of proximal MCA (show RSPH1 Proteins) occlusion.
UCP2 inhibits myointimal hyperplasia after vascular injury, probably through suppressing nuclear factor-kappaB-dependent smooth muscle cell proliferation and migration.
Study shows that the mitochondrial uncoupling protein 2 rs659366 A allele and rs660339 T allele are both related to longer leukocyte telomere in subjects without diabetes, independent of cardiovascular risk factors.
Evaluated association between nonalcoholic fatty liver disease (NAFLD) and single nucleotide polymorphism 866G of human uncoupling protein 2 (UCP2).
The present study identified a novel gene, UCP2, that influences the serum urate concentration and the risk of hyperuricemia, and the degree of association varies with gender and BMI levels.
UCP2 regulates the activity of SIRT3 (show SIRT3 Proteins) through sensing the energy level and, in turn, maintaining the mitochondrial steady state, which demonstrates a cytoprotective effect on ischemia-reperfusion injury.
UCP2 is a key mediator of hypoxia-triggered chemoresistance in non-small cell lung cancer cells via repression of peroxisome proliferator-activated receptor gamma (show PPARG Proteins).
Results here presented suggest that UCP (show UCP1 Proteins) variability has different pleiotropic effects, by affecting both telomere length and glucose homeostasis, likely through an influence on energy metabolism and stress response
Study provides evidence that UCP2 plays a protecting role against LPS (show TLR4 Proteins) by regulating the balance between autophagy and apoptosis of cardiomyocytes, and by which mechanisms, it may contribute to homeostasis of cardiac function and cardiomyocytes activity.
Upregulation of UCP2 conferred protective effects to the stressed beta-cell through mechanisms not directly associated with superoxide production.
UCP2-dependent modulations have a major impact on cardiac electrophysiology.
UCP2 regulates embryonic neurogenesis through reactive oxygen species-mediated Yap (show YAP1 Proteins) alternation, thus shedding new sight on mitochondrial metabolism involved in embryonic neurogenesis.
Data demonstrate that UCP2 controls pancreas development through the ROS (show ROS1 Proteins)-AKT (show AKT1 Proteins) signaling pathway.
UCP2 has two glycine-rich motifs, motif 1: EGIRGLWKG (170-178) and a Walker A-like motif 2: EGPRAFYKG (264-272). These motifs seem to be important for the function of UCP2. UCP2/K177E- or UCP2/G174L-expressed cells did not induce enlarged cell shapes. UCP2/K177E and UCP2/G174L produced functional incompetence of the glycine-rich motif 1. Senescent-like cells significantly decreased the mitochondrial membrane potentials.
our findings reveal that UCP2 regulates inflammation responses in astrocytes and plays an important role in the pathogenesis of depression and that UCP2 may be a promising therapeutic target for depression.
These results suggest that Leishmania exploits A20 (show TNFAIP3 Proteins) and UCP2 to impair inflammasome activation for disease propagation
UCP-2 prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E (show APOE Proteins)-knockout mice via antioxidant and antiapoptotic activities.
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Proteins) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Proteins)) in Angus steers selected to have high or low RFI (show RNF34 Proteins) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial