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Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with hypertension in a Chinese female population. Additionally, we demonstrated that genotype Asn89Asn was associated with left ventricular posterior wall thickness for subjects with hypertension and cardiac hypertrophy in a Chinese female population.
Children and adolescents with CKD, particularly those who are not on hemodialysis (HD) and renal transplantation, have significantly higher levels of UII than healthy subjects. UII levels increase significantly at the end of the HD session. The presence of metabolic acidosis affects significantly plasma UII levels.
UII/GPR14 signaling was involved in the DSS (show NR0B1 Proteins)-induced colonic inflammation and its inhibition may serve as a potential therapeutic target, which may be associated with the NF-kappaB (show NFKB1 Proteins) signaling pathway.
Ser89Asn polymorphisms of the UTS2 gene are significantly associated with atrial fibrillation in the Chinese population. Additionally, we demonstrated that genotype Met21Met may have a potential beneficial role in atrial fibrillation.
Serum urotensin II levels were significantly lower in hemodialysis patients compared to healthy subjects.
expression of UII is associated with ERS in patients with SPE. Our results indicate that UII may trigger ERS in placental trophoblastic cells in patients with preeclampsia.
Our study suggests that U-II may play a role in migraine pathogenesis; also Thr21Met polymorphism was associated with the risk of migraine disease.
Used transgenic rabbits as a model to study macrophage-specific expressing human UII (hUII) and studied the role of autocrine UII in the development of atherosclerosis.
Urotensin II-increased reactive oxygen species production via the NADPH oxidase (show NOX1 Proteins) pathway is partially associated with activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) cascades
provide evidence that, in glioma cells, homogeneous concentration of UII allowed translocation of Galpha13 (show GNA13 Proteins) to the UT receptor at the plasma membrane and increased actin stress fibers, lamellipodia formation and vinculin (show VCL Proteins)-stained focal adhesions
IRF3 (show IRF3 Proteins) expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver
Urotensin II plays a role in the pathogenesis and priming of acute liver failure by triggering an inflammatory cascade and driving the early release of TNF-alpha (show TNF Proteins) and Il1beta (show IL1B Proteins).
UII/UTR system plays a role in lipopolysaccharide (LPS (show TLR4 Proteins))/D-galactosamine (GalN (show GAL Proteins))-induced acute liver failure.
Data suggest that aortic urotensin II (UII) is increased in diabetes-associated atherosclerosis in humans and mice; diabetes-associated plaque development is attenuated by UII/UII receptor antagonism in in vitro (human) and in vivo (mouse) settings.
It is believed that U-II is an important mediator in Systemic sclerosis.
role of urotensin II gene deletion in atherosclerosis and suggest that the use of pharmaceutical agents aimed at blocking the urotensin II pathway may provide a novel approach in the treatment of atherosclerosis.
mouse UII is expressed in a subpopulation of motoneurons in the spinal cord
In the CNS UII mRNAs are expressed in brainstem and spinal motoneurons, also expressed in the medial vestibular nucleus, locus coeruleus and the ventral medulla.
increased plasma urotensin II level stimulates oxidized low-density lipoprotein and reactive oxygen species production and macrophage foam cell formation
Elevated expression of Uts2 in skeletal muscle of diabetic mouse is reported.
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
, prepro U-II
, urotensin II
, urocortin 2