Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Mouse (Murine) ARHGEF2 Antibodies:
anti-Human ARHGEF2 Antibodies:
anti-Rat (Rattus) ARHGEF2 Antibodies:
Go to our pre-filtered search.
Human Monoclonal ARHGEF2 Primary Antibody for FACS, WB - ABIN2192013
Benais-Pont, Punn, Flores-Maldonado, Eckert, Raposo, Fleming, Cereijido, Balda, Matter: Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. in The Journal of cell biology 2003
Show all 4 Pubmed References
GEF-H1 was a novel regulator of inflammatory cytokine production and mycobacterial elimination, and may serve as a novel potential target for clinical treatment of tuberculosis.
Autophagic regulation of RhoA (show RHOA Antibodies) activity was dependent on GEF-H1 which directly bound to p62 (show GTF2H1 Antibodies) and was degraded by autophagy, resulting in low RhoA (show RHOA Antibodies) activity. In contrast, the loss of autophagy increased GEF-H1 levels and thereby activated RhoA (show RHOA Antibodies), which caused cells to move by amoeba-like migration. This amoeba-like migration was cancelled by the silencing of GEF-H1.
human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.
These results identify GEF-H1 as a component of the shear stress response machinery in neutrophils required for a fully competent immune response to bacterial infection.
Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (show TAS1R3 Antibodies)) ligands that is independent of microtubule depolymerization.
Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (show DDX58 Antibodies)-like receptors.
Pak2 (show PAK2 Antibodies), but not Pak1 (show PAK1 Antibodies), negatively regulates RhoA (show RHOA Antibodies) via phosphorylation of the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (show RHOA Antibodies) stimulation
It was shown that the guanine exchange factors GEF-H1 and ECT2 (show ECT2 Antibodies) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (show ECT2 Antibodies) downregulation.
CAPN6 (show CAPN6 Antibodies) acts as a regulator of Rac1 (show RAC1 Antibodies) and cell motility through interaction with GEF-H1.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
Authors identified a regulatory switch controlled by MARK3 (show MARK3 Antibodies) that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2.
depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly.
Overexpression of miR (show MLXIP Antibodies)-194 downregulates the GEF-H1/RhoA (show RHOA Antibodies) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (show MLXIP Antibodies)-194 expression is negatively associated with tumor-node-metastasis (TNM (show ODZ1 Antibodies)) stages
data suggest that the induction of SGK1 (show SGK1 Antibodies) through treatment with dexamethasone alters MT dynamics to increase Sec5 (show EXOC2 Antibodies)-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.
this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.
By stimulating cofilin (show CFL1 Antibodies)/PP2A (show PPP2R4 Antibodies)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 Antibodies) GEF-H1.
regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms
Results supported that miR (show MLXIP Antibodies)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 (show RAC1 Antibodies) activity via DOCK3 (show DOCK3 Antibodies) in NSCLC A549 and H1299 cell lines.
TGF-beta (show TGFB1 Antibodies) regulates LARG (show ARHGEF12 Antibodies) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE (show ADAM17 Antibodies), and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1.
Data indicate that GEF-H1 is a target and functional effector of TGF-beta (show TGFB1 Antibodies) by orchestrating Rho signaling to regulate gene expression and cell migration.
ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.
the ERK (show MAPK1 Antibodies)/GEF-H1/Rho/Rho kinase (show ROCK1 Antibodies)/phospho-MLC pathway is the mechanism mediating TNF-alpha (show TNF Antibodies)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Rho/Rac guanine nucleotide exchange factor (GEF) 2
, guanine nucleotide exchange factor LFC
, Rho/Rac guanine nucleotide exchange factor 2
, rho guanine nucleotide exchange factor 2-like
, LBC'S first cousin
, guanine nucleotide exchange factor H1
, lymphoid blast crisis-like 1
, oncogene LFC
, rho guanine nucleotide exchange factor 2
, microtubule-regulated Rho-GEF
, proliferating cell nucleolar antigen p40
, Guanine nucleotide exchange factor H1
, rho/rac guanine nucleotide exchange factor 2
, tight junction-associated guanine nucleotide exchange factor