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TAF9 directly binds HCA587/MAGEC2 through its CR domain, suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA to regulate certain genes transcription.
findings suggest that p53 sequesters TAF9 from GLI1, which may contribute to inhibition of GLI1 activity by p53
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
TAF9 depletion severely disrupts TFIID, indicating that the observed ongoing transcription is initiated with at least partially TAF-free TATA-binding protein.
IL-1-inducible phosphorylation of p65 NFkB is mediated by multiple protein kinases including IKKalpha, IKKbeta, IKKepsilon, TBK1, and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription
histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs
suggest a novel STAF65gamma-dependent function of STAGA-type complexes in cell proliferation and transcription activation by MYC postloading of TFIID and RNA polymerase II that involves direct recruitment of core Mediator
TAF9 functionally supports EKLF activity by enhancing its ability to activate the beta-globin gene. TAF9 interacts with a conserved beta-globin downstream promoter element
Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms.
, ATP-AMP transphosphorylase 6
, RNA polymerase II TBP-associated factor subunit G
, adenylate kinase 6
, adenylate kinase isoenzyme 6
, adrenal gland protein AD-004
, coilin interacting nuclear ATPase protein
, coilin interacting protein
, coilin-interacting nuclear ATPase protein
, dual activity adenylate kinase/ATPase
, transcription initiation factor TFIID 31 kD subunit
, transcription initiation factor TFIID 31 kDa subunit
, transcription initiation factor TFIID 32 kDa subunit
, TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32 kDa
, transcription initiation factor TFIID subunit 9
, TAF9 RNA polymerase II, TATA box binding protein-associated factor
, TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
, TBP-associated factor 9