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Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731
Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008
Sgk1 (show SGK1 Antibodies) stimulated OAT3 (show SLC22A8 Antibodies) transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3 (show SLC22A8 Antibodies)-mediated drug elimination is regulated in vivo.
ULK1 (show ULK1 Antibodies) phosphorylation at 3 different sites on the same ULK1 (show ULK1 Antibodies) target region for NEDD4L is preparatory for its ubiquitylation and subsequent degradation.
WW3 and WW4 domains of Nedd4-2 are critical for its association with and modulation of the transporter.
study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L and CYP11beta2
Collectively, Nedd4L plays a tumor suppressive role in HCC (show FAM126A Antibodies), possibly through triggering MAPK/ERK (show MAPK1 Antibodies)-mediated apoptosis, and Nedd4L downregulation may be a potential prognostic biomarker as well as a therapeutic target for HCC (show FAM126A Antibodies).
evidence implicating E3 ubiquitin ligase (show MUL1 Antibodies) NEDD4L in the pathogeny of periventricular nodular heterotopia
This study demonstrated that it is possible to downregulate Kv1.3 (show KCNA3 Antibodies) channel density through activation of an E3 ubiquitin ligase (show MUL1 Antibodies) and that inhibition of the protease pathway or mutation of the Nedd4-2 catalytic site prevents Kv1.3 (show KCNA3 Antibodies) modulation.
These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (show XBP1 Antibodies) and that this is important in the induction of an appropriate autophagic response.
both Nedd4-1 (show NEDD4 Antibodies) and Nedd4-2 are important regulators for hOAT1 (show SLC22A6 Antibodies) ubiquitination, expression, and function
USP36 (show USP36 Antibodies) actions extend beyond TrkA (show NTRK1 Antibodies) because the presence of USP36 (show USP36 Antibodies) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Antibodies)/3 channel regulation.
these findings suggest that regulation of Dvl (show DVL2 Antibodies) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Antibodies)-activated kinase promotes ENaC (show SCNN1A Antibodies)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Antibodies) by increasing Nedd4-2-dependent ENaC (show SCNN1A Antibodies) retrieval from the plasma membrane.
results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 (show KCNQ1 Antibodies) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.
ENaC-beta (show SCNN1B Antibodies) regulation that occurs through IKKbeta (show IKBKB Antibodies)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Antibodies) and protein kinase A target site.
Findings indicate an important negative regulatory function for Nedd4 ubiquitin protein ligase (show UBE2K Antibodies) (Nedd4-2) and Nedd4 family interacting protein 1 (Ndfip1 (show NDFIP1 Antibodies)) in IgE-dependent mast cell activity.
Data indicate that ENaC (show SCNN1A Antibodies) is the primary in vivo target of NEDD4-2 and that Nedd4-2 deletion is associated with hypertension on a normal Na(+) diet. Findings provide further insight into the critical function of NEDD4-2 in renal pathophysiology.
Nedd4-2 heterozygotes are hyperactive, have increased basal synaptic transmission and have enhanced sensitivity to inflammatory pain. They provide a new genetic model to study inflammatory pain.
Findings demonstrate that during a high oral salt intake the Nedd4-2-containing C2 domain protein plays a pivotal role in maintaining adaptive salt handling in the kidney.
These results suggested that Nedd4-2 with C2 domain might play a pivotal role in cardio-renal associations through post-transcriptional modification of both epithelial sodium channel and cardiac ion channels, which are critical for kidney and heart functions.
Nedd4-2 knockdown ameliorates movement disorders in PD mice.
Tmbim1 (show TMBIM1 Antibodies) promoted the lysosomal degradation of toll-like receptor 4 (show TLR4 Antibodies) by cooperating with the ESCRT endosomal sorting complex to facilitate MVB formation, and the ubiquitination of Tmbim1 (show TMBIM1 Antibodies) by the E3 ubiquitin ligase (show MUL1 Antibodies) Nedd4l was required for this process.
These results identify NKCC1 (show SLC12A2 Antibodies) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Antibodies)).
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Antibodies)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Antibodies) receptor GluA1 (show GRIA1 Antibodies) ubiquitination.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b