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Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731
Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008
evidence implicating E3 ubiquitin ligase (show MUL1 Antibodies) NEDD4L in the pathogeny of periventricular nodular heterotopia
This study demonstrated that it is possible to downregulate Kv1.3 (show KCNA3 Antibodies) channel density through activation of an E3 ubiquitin ligase (show MUL1 Antibodies) and that inhibition of the protease pathway or mutation of the Nedd4-2 catalytic site prevents Kv1.3 (show KCNA3 Antibodies) modulation.
These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (show XBP1 Antibodies) and that this is important in the induction of an appropriate autophagic response.
both Nedd4-1 (show NEDD4 Antibodies) and Nedd4-2 are important regulators for hOAT1 (show SLC22A6 Antibodies) ubiquitination, expression, and function
USP36 (show USP36 Antibodies) actions extend beyond TrkA (show NTRK1 Antibodies) because the presence of USP36 (show USP36 Antibodies) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Antibodies)/3 channel regulation.
NEDD4L negatively regulates PIK3CA (show PIK3CA Antibodies) protein levels via ubiquitination and is required for the maintenance of PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway.
overexpression of miR (show MLXIP Antibodies)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Antibodies) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Antibodies)-93 in lung tumorigenesis and metastasis.
the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.
Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2.
Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Antibodies) ubiquitination, and inhibited hOAT4 (show SLC22A9 Antibodies) transport activity.
these findings suggest that regulation of Dvl (show DVL2 Antibodies) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Antibodies)-activated kinase promotes ENaC (show SCNN1A Antibodies)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Antibodies) by increasing Nedd4-2-dependent ENaC (show SCNN1A Antibodies) retrieval from the plasma membrane.
results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 (show KCNQ1 Antibodies) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
This study suggested that Nedd4-regulated PTEN (show PTEN Antibodies) is a key regulator of terminal arborization in vivo.
ENaC-beta (show SCNN1B Antibodies) regulation that occurs through IKKbeta (show IKBKB Antibodies)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Antibodies) and protein kinase A target site.
Nedd4-2 knockdown ameliorates movement disorders in PD mice.
Tmbim1 (show TMBIM1 Antibodies) promoted the lysosomal degradation of toll-like receptor 4 (show TLR4 Antibodies) by cooperating with the ESCRT endosomal sorting complex to facilitate MVB formation, and the ubiquitination of Tmbim1 (show TMBIM1 Antibodies) by the E3 ubiquitin ligase (show MUL1 Antibodies) Nedd4l was required for this process.
These results identify NKCC1 (show SLC12A2 Antibodies) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Antibodies)).
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Antibodies)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Antibodies) receptor GluA1 (show GRIA1 Antibodies) ubiquitination.
These findings elucidate a critical role of Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
We identified glutamate (show GRIN1 Antibodies) receptor subunit 1 (GluA1 (show GRIA1 Antibodies)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2
The short isoform of the ubiquitin ligase (show RNF123 Antibodies) NEDD4L is a CREB (show CREB1 Antibodies) target gene in hepatocytes.
Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Antibodies) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b