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anti-Human ARHGEF11 Antibodies:
anti-Mouse (Murine) ARHGEF11 Antibodies:
anti-Rat (Rattus) ARHGEF11 Antibodies:
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Human Polyclonal ARHGEF11 Primary Antibody for IHC, IHC (p) - ABIN4281541
Rozbicki, Chuai, Karjalainen, Song, Sang, Martin, Knölker, MacDonald, Weijer: Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation. in Nature cell biology 2015
Show all 2 Pubmed References
Cow (Bovine) Polyclonal ARHGEF11 Primary Antibody for IHC (p), WB - ABIN4281543
Jia, Johnson, Wang, Guo, Dreisbach, Lewin, Kyle, Garrett: Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. in PLoS ONE 2015
RhoGEF plays essential role in ciliated epithelia during vertebrate development.
Agonist-induced Ca2 (show CA2 Antibodies)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
PAK4 (show PAK4 Antibodies) (but not PAK1 (show PAK1 Antibodies)) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF.
Data show that endothelin A receptor (show EDNRA Antibodies) drives invadopodia function by direct interaction of beta-arrestin-1 (show ARRB1 Antibodies) (beta-arr1 (show ARRB1 Antibodies)) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF).
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG (show ARHGEF12 Antibodies)), use their PDZ (show INADL Antibodies) domains to bind class B plexins and play critical roles in signaling.
Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS (show PITX2 Antibodies))-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115 (show ARHGAP4 Antibodies), PDZ-RhoGEF (PRG (show PRB3 Antibodies)), and leukemia-associated RhoGEF (LARG (show ARHGEF12 Antibodies)).
The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin (show INS Antibodies) resistance in a Chinese population.
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF (show SLC2A4RG Antibodies)(LARG (show ARHGEF12 Antibodies)) and this protein.
These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
results suggest that ARHGEF11 mediates RhoA (show RHOA Antibodies)-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1 (show TJP1 Antibodies)
PDZ-RhoGEF interacts directly with p21-activated kinase 4 (show PAK4 Antibodies) to negatively regulate the activation of Rho
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
, rho guanine nucleotide exchange factor 11
, Rho guanine nucleotide exchange factor (GEF) 11
, rho guanine nucleotide exchange factor 11-like
, Rho guanine exchange factor (GEF) 11
, RhoA-specific guanine nucleotide exchange factor
, RhoGEF glutamate transport modulator
, glutamate transporter EAAT4-associated protein 48
, RhoGEF glutamate transport modulator GTRAP48
, glutamate transporter EAAT4 associated protein 48