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anti-Human ARHGEF11 Antibodies:
anti-Mouse (Murine) ARHGEF11 Antibodies:
anti-Rat (Rattus) ARHGEF11 Antibodies:
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Human Polyclonal ARHGEF11 Primary Antibody for IHC, IHC (p) - ABIN4281541
Rozbicki, Chuai, Karjalainen, Song, Sang, Martin, Knölker, MacDonald, Weijer: Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation. in Nature cell biology 2015
Show all 2 Pubmed References
Human Polyclonal ARHGEF11 Primary Antibody for ICC, IF - ABIN438499
Ding, Dhruv, Kwiatkowska-Piwowarczyk, Ruggieri, Kloss, Symons, Pirrotte, Eschbacher, Tran, Loftus: PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival. in Neoplasia (New York, N.Y.) 2019
Cow (Bovine) Polyclonal ARHGEF11 Primary Antibody for IHC (p), WB - ABIN4281543
Jia, Johnson, Wang, Guo, Dreisbach, Lewin, Kyle, Garrett: Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. in PLoS ONE 2015
RhoGEF plays essential role in ciliated epithelia during vertebrate development.
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
PDZ-RhoGEF role in the glioblastoma cell invasion and survival.PDZ-RhoGEF is an effector of TROY signaling.
ARHGRF11 inhibited the insulin signaling pathway in placenta and may participate in fetal macrosomia in normal glucose tolerance pregnant women
SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF.
Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF).
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population.
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein.
PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho
ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia
PDZ-RhoGEF interacts with the actin cytoskeleton
Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors.
This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer.
Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance.
Sequence variation in this gene may influence susceptibility to and risk of type II diabetes.
These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
results suggest that ARHGEF11 mediates RhoA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1
Required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
, rho guanine nucleotide exchange factor 11
, Rho guanine nucleotide exchange factor (GEF) 11
, rho guanine nucleotide exchange factor 11-like
, Rho guanine exchange factor (GEF) 11
, RhoA-specific guanine nucleotide exchange factor
, RhoGEF glutamate transport modulator
, glutamate transporter EAAT4-associated protein 48
, RhoGEF glutamate transport modulator GTRAP48
, glutamate transporter EAAT4 associated protein 48