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PDZ-RhoGEF role in the glioblastoma cell invasion and survival.PDZ-RhoGEF is an effector of TROY signaling.
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ARHGRF11 inhibited the insulin signaling pathway in placenta and may participate in fetal macrosomia in normal glucose tolerance pregnant women
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SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
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PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF.
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Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF).
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Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
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Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia
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Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
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Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
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analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
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Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
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The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population.
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Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein.
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PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho
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ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia
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PDZ-RhoGEF interacts with the actin cytoskeleton
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Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors.
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This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer.
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Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance.
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Sequence variation in this gene may influence susceptibility to and risk of type II diabetes.
