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Authors found that ARHGEF16 mRNA level was upregulated in U87 cells overexpressing GLI2A relative to control cells. GLI2 binds to the ARHGEF16 promoter and activates gene transcription. Glioma cells U87 and U118 overexpressing ARHGEF16 showed enhanced migration and proliferation.
Sixty-four novel structural analogues of Y27632 were synthesized and tested for their ability to persistently inhibit the transformation of NIH3T3 cells by Rho guanidine exchange factor 16 (ARHGEF16) or Ras.
These data suggest that HPV16 E6, Tip-1 and ARHGEF16 may cooperate to activate Cdc42 and support a potential link between the expression of HPV16 E6 and Cdc42 activation
The ephexin4 protein mediates cell migration through a RhoG-dependent mechanism.
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions.
rho guanine nucleotide exchange factor 16
, Rho guanine exchange factor 16
, Rho guanine exchange factor (GEF) 16
, Rho guanine nucleotide exchange factor (GEF) 16
, rho guanine nucleotide exchange factor 16-like
, Rho guanine nucleotide exchange factor