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BEX1 functions as an mRNA-dependent effector that augments pathology-promoting gene expression during heart failure.
These results elucidate a novel role of Bex1 in myogenesis through regulating myoblast fusion.
Bex family members play important roles in the formation of protein network hubs.
Bex1 protein is over-expressed as a result of peripheral axonal damage and antagonizes the axon outgrowth inhibitory effect of myelin-associated glycoprotein.
Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos.
In situ hybridization demonstrates cellular co-localization of olfactory marker protein mRNA with mRNAs for Bex1, Bex2, and Bex3 in olfactory receptor neuronss in olfactory tissue of the mouse
Bex3 may be required in target tissues for mitochondrial function at a distinct phase of the cellular growth cycle.
Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca(2+)/CaM may be involved in skeletal muscle regeneration.
Bex1 and 2 have been characterized as interacting partners of the olfactory marker protein (OMP). Bex immunoreactivity (ir) was primarily localized to neuronal cells within several regions of the brain.
BEX1 was downregulated in esophageal squamous cell cancer (ESCC) tissues compared to adjacent normal tissues, and low BEX1 expression was significantly associated with larger tumor volume, advanced clinical, and poor survival in patients with ESCC.
loss of BEX1 expression in FLT3-ITD driven AML potentiates oncogenic signaling and leads to decreased overall survival
Our results revealed an interaction between BEX1 and BCL-2 and a novel mechanism of imatinib resistance mediated by the BEX1/BCL-2 pathway.
Epigenetic inactivation of BEX1 supports its role as a candidate tumour suppressor gene in intracranial ependymoma
Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence.
This new human gene is mapped to the X chromosome and has an expression pattern of a spermatogenesis-related gene.
Two novel brain expressed genes, BEX1 and BEX2 are identified; they are silenced in all glioma specimens and exhibit extensive promoter hypermethylation.
expression of hBex1 in leukemic cells is a novel mechanism by which chemoresistance is achieved and suggests that hBex1 is a potential molecular target for the development of novel leukemia treatments
Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).
brain expressed, X-linked 1
, brain-expressed X-linked protein 1 homolog
, protein BEX1
, reduced expression 3
, reduced expression protein 3
, brain-expressed X-linked protein 2 homolog
, protein BEX2
, brain-expressed X-linked protein 1
, ovarian granulosa cell 13.0 kDa protein hGR74
, brain expressed gene 1