Protein Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Alternative names and synonyms associated with Dual Specificity Phosphatase 3 (DUSP3)

• dual specificity phosphatase 3 (DUSP3) antibody
• dual specificity phosphatase 3b (dusp3b) antibody
• dual specificity phosphatase 3 (Dusp3) antibody
• dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3) antibody

• 2210015O03Rik antibody
• 5031436O03Rik antibody
• dusp3 antibody
• RGD1560049 antibody
• si:bz18k17.3 antibody
• Show all synonym aliases
• si:rp71-18k17.3 antibody
• T-DSP11 antibody
• VHR antibody

Protein level used designations for DUSP3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) , dual specificity phosphatase 3 , dual specificity protein phosphatase 3 , dual specificity protein phosphatase VHR , serine/threonine specific protein phosphatase , vaccinia H1-related phosphatase , vaccinia virus phosphatase VH1-related