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anti-Human HDAC3 Antibodies:
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Human Polyclonal HDAC3 Primary Antibody for ChIP, ICC - ABIN151195
Cress, Seto: Histone deacetylases, transcriptional control, and cancer. in Journal of cellular physiology 2000
Show all 9 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for ICC, IF - ABIN152952
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 14 Pubmed References
Human Monoclonal HDAC3 Primary Antibody for IHC, ELISA - ABIN969189
Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. in Molecular and cellular biology 2007
Show all 3 Pubmed References
Human Monoclonal HDAC3 Primary Antibody for ICC, ELISA - ABIN969188
Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: HDAC3 overexpression and colon cancer cell proliferation and differentiation. in Molecular carcinogenesis 2008
Show all 3 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for ICC, IF - ABIN256669
Inoue, Mai, Dyer, Cohen: Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. in Cancer research 2006
Show all 3 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for WB - ABIN2668681
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Show all 3 Pubmed References
Chicken Polyclonal HDAC3 Primary Antibody for IHC, WB - ABIN223297
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
Show all 2 Pubmed References
Dog (Canine) Monoclonal HDAC3 Primary Antibody for IF, WB - ABIN968379
Emiliani, Fischle, Van Lint, Al-Abed, Verdin: Characterization of a human RPD3 ortholog, HDAC3. in Proceedings of the National Academy of Sciences of the United States of America 1998
Human Monoclonal HDAC3 Primary Antibody for ELISA, IHC - ABIN2869346
Brodie, Li, El-Kommos, Kang, Ramalingam, Behera, Gandhi, Kowalski, Sica, Khuri, Vertino, Brandes: Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2014
Human Monoclonal HDAC3 Primary Antibody for IP, WB - ABIN2668680
Mueller, Breuer, Schmitt, Walter, Evert, Wüllner: CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3. in Human molecular genetics 2009
Brm (show SMARCA2 Antibodies)-HDAC3-Erm (show MSN Antibodies) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
) DHDAC1 (show HDAC1 Antibodies) and -3 have distinct functions in the control of gene expression
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
Knockdown of either Xist or SPEN (show SPEN Antibodies) expression in breast cancer cells suppressed the expression of PHLPP1 (show PHLPP1 Antibodies), a phosphatase in AKT (show AKT1 Antibodies) dephosphorylation, and was correlated with increased HDAC3 recruitment to the PHLPP1 (show PHLPP1 Antibodies) promoter.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Data show that the nuclear HDAC3 and cytoplasmic CDH1 (show CDH1 Antibodies) have independent prognostic value in pancreatic cancer and provide targets for prognostic therapeutics.
HDAC3 uniquely primes Ucp1 (show UCP1 Antibodies) and the thermogenic transcriptional program to maintain a critical capacity for thermogenesis in brown adipose tissue that can be rapidly engaged upon exposure to dangerously cold temperature
The low expression of HDAC3 and overexpession of inflammatory cytokines (IL-18 (show IL18 Antibodies), IL-12 (show IL12A Antibodies) and TNF-alpha (show TNF Antibodies)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
SNP rs14251 was found to be significant (and rs2530223 to be nominally significantly associated with the increasing risk of SCZ susceptibility in Han Chinese individuals, suggesting this gene as a potential genetic modifier for SCZ development.
Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.
that histone deacetylase 3 interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Antibodies) deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment
provide evidence to show that CBX4 (show CBX4 Antibodies) may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 (show RUNX2 Antibodies) promoter to impede Runx2 (show RUNX2 Antibodies) expression
miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 and SENP1 (show SENP1 Antibodies) expression.
HDAC3 interacts with PROX1 (show C16orf35 Antibodies).HDAC3 controls expression of genes regulating lipid homeostasis.
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3 (show STAT3 Antibodies)) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3). (HDAC3) and caspase 3 (show CASP3 Antibodies).
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 (show RAE1 Antibodies) family of NKG2D (show KLRK1 Antibodies) ligands. RAE-1 (show RAE1 Antibodies) is transcriptionally repressed by histone deacetylase (show HDAC1 Antibodies) inhibitor 3 (show PPP1R11 Antibodies) (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Antibodies) and preventing it from activating HDAC3.
Emerin (show EMD Antibodies)-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC (show MYH13 Antibodies)) expression and formed fewer myotubes. Emerin (show EMD Antibodies) binds to and activates histone deacetylase 3 (HDAC3).
Hdac3 is a key epigenetic modifier that maintains blood-lymph separation and integrates both extrinsic forces and intrinsic cues to regulate lymphatic valve development.
HDAC3 controls the temporal and spatial expression of tissue-remodeling genes and inflammatory responses in chondrocytes to ensure proper endochondral ossification during development.
HDAC3, through deacetylating tubulin (show TUBB Antibodies), promotes microtubule stability and the establishment of kinetochore-microtubule interaction, consequently ensuring proper spindle morphology, accurate chromosome movement and orderly meiotic progression during oocyte maturation
These studies showed that HDAC3 regulates WAT metabolism by activating a futile cycle (show LRMP Antibodies) of fatty acid synthesis and oxidation, which supports WAT browning.
Hdac3 tethers peripheral heterochromatin containing lineage-relevant genes to the nuclear lamina. Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from the nuclear periphery, leading to precocious cardiac gene expression and differentiation into cardiomyocytes; in contrast, restricting Hdac3 to the nuclear periphery rescues myogenesis in progenitors otherwise lacking Hdac3.
These in vivo results point to the potential use of selective HDAC3 inhibitors as a therapeutic approach to suppress pancreatic islet infiltration and prevent beta-cell death with the long-term goal of limiting the progression of type 1 diabetes.
HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development.
These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Antibodies) and hdac3 in zebrafish embryonic development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
, histone Deacetylase-3
, histone deacetylase 3
, HDAC3 splicing HDAC3alpha
, HDAC3 splicing HDAC3beta
, HDAC3 splicing HDAC3delta
, HDAC3 splicing HDAC3gamma
, histone deacetylase-3