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anti-Human HDAC3 Antibodies:
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Human Polyclonal HDAC3 Primary Antibody for ChIP, ICC - ABIN151195
Cress, Seto: Histone deacetylases, transcriptional control, and cancer. in Journal of cellular physiology 2000
Show all 9 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for ICC, IF - ABIN152952
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 14 Pubmed References
Human Monoclonal HDAC3 Primary Antibody for ICC, ELISA - ABIN969188
Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. in Molecular and cellular biology 2007
Show all 3 Pubmed References
Human Monoclonal HDAC3 Primary Antibody for IHC, ELISA - ABIN969189
Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: HDAC3 overexpression and colon cancer cell proliferation and differentiation. in Molecular carcinogenesis 2008
Show all 3 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for ICC, IF - ABIN256669
Inoue, Mai, Dyer, Cohen: Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. in Cancer research 2006
Show all 3 Pubmed References
Human Polyclonal HDAC3 Primary Antibody for WB - ABIN2668681
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Show all 3 Pubmed References
Chicken Polyclonal HDAC3 Primary Antibody for IHC, WB - ABIN223297
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
Show all 2 Pubmed References
Human Monoclonal HDAC3 Primary Antibody for ELISA, IHC - ABIN2869346
Brodie, Li, El-Kommos, Kang, Ramalingam, Behera, Gandhi, Kowalski, Sica, Khuri, Vertino, Brandes: Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2014
Human Monoclonal HDAC3 Primary Antibody for IP, WB - ABIN2668680
Mueller, Breuer, Schmitt, Walter, Evert, Wüllner: CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3. in Human molecular genetics 2009
Brm (show SMARCA2 Antibodies)-HDAC3-Erm (show MSN Antibodies) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
) DHDAC1 (show HDAC1 Antibodies) and -3 have distinct functions in the control of gene expression
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
High HDAC3 expression is closely correlated with ER-negative expression, PR-negative expression, HER2 (show ERBB2 Antibodies) overexpression, PT stage, and clinical stage of breast tumors.
these findings indicate that AKAP12 (show AKAP12 Antibodies) may be a potential prognostic predictor and therapeutic target for the treatment of colorectal cancer in combination with HDAC3
CHD5 (show WRB Antibodies) was identified as a direct target of miR (show MLXIP Antibodies)-454. CHD5 (show WRB Antibodies) was downregulated in GC tissues/cell lines and the expresssion of CHD5 (show WRB Antibodies) inversely correlated with the level of miR (show MLXIP Antibodies)-454 in GC tissues. Taken together, these observations indicate that HDAC3 is associated with GC cell growth via the miR (show MLXIP Antibodies)-454-mediated targeting of CHD5 (show WRB Antibodies).
DANCR associated with EZH2 (show EZH2 Antibodies) and HDAC3 to epigenetically silence lncRNA-LET and then regulated gastric cancer cells migration and invasion.
Data show there is allosteric communication between the inositol-binding site and the active sites in histone deacetylases HDAC1 (show HDAC1 Antibodies) and HDAC3.
Results show that proteasomal degradation of HDAC1 (show HDAC1 Antibodies) and HDAC3 by Vpr counteracts HIV-1 latency to reactivate the viral promoter.
the NCOR (show NCOR1 Antibodies)/HDAC3 complex is a major suppressor of differentiation in rhabdomyosarcoma
These findings indicate the importance of developing HDAC3-selective inhibitors, and their combined use with osimertinib, for treating EGFR (show EGFR Antibodies)-mutated lung cancers carrying the BIM (show BCL2L11 Antibodies) deletion polymorphism
HDAC3-mediated p53 (show TP53 Antibodies) acetylation and oligomerization is induced by apoptosis caused by delphinidin in prostate cancer cells
Knockdown of either Xist or SPEN (show SPEN Antibodies) expression in breast cancer cells suppressed the expression of PHLPP1 (show PHLPP1 Antibodies), a phosphatase in AKT (show AKT1 Antibodies) dephosphorylation, and was correlated with increased HDAC3 recruitment to the PHLPP1 (show PHLPP1 Antibodies) promoter.
HDAC3 plays an important role in regulating insulin (show INS Antibodies) secretion.
Epithelial HDAC3 promotes development of diet-induced obesity in studies of mice.
Hdac3 regulates distinct pathways in mesenchymal cell populations and is required for mesenchymal progenitor cell differentiation and long bone development.
Results suggest that the deacetylase domain of HDAC3 plays a selective role in specific brain regions underlying long-term memory formation of object location as well as cocaine-associated memory formation and extinction.
Reintroduction of wild-type Hdac3 restored normal B-cell development, whereas an Hdac3 point mutant lacking deacetylase activity failed to complement this defect. Thus, the deacetylase activity of Hdac3 is required for the generation of mature B cells.
HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.
Selective HDAC3 inhibition effectively alleviated Klotho (show KL Antibodies) loss and kidney injury, whereas the protective effects were largely abolished when Klotho (show KL Antibodies) was knocked down by siRNA, suggesting that aberrant HDAC3 and Klotho (show KL Antibodies) loss are crucial components involved in the renal damage of mice with chronic kidney disease.
HDAC3 deletion displayed decreased pancreatic insulin content, disrupted glucose-stimulated insulin secretion, with intermittent spontaneous diabetes and dramatically enhanced susceptibility to STZ-induced diabetes.
Mice lacking HDAC3 in intestinal epithelial cells were more susceptible to Citrobacter rodentium. HDAC3 mediates communication between intestinal epithelial cells and resident lymphocytes.
Hepcidin (show HAMP Antibodies) expression involves epigenetic regulation by histone deacetylase 3.
HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development.
These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Antibodies) and hdac3 in zebrafish embryonic development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
, histone Deacetylase-3
, histone deacetylase 3
, HDAC3 splicing HDAC3alpha
, HDAC3 splicing HDAC3beta
, HDAC3 splicing HDAC3delta
, HDAC3 splicing HDAC3gamma
, histone deacetylase-3