Browse our anti-HDAC3 (HDAC3) Antibodies

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 3 (HDAC3) interaction partners

1. Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.

2. Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.

3. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.

4. ) DHDAC1 and -3 have distinct functions in the control of gene expression

5. Histone deacetylation is a repression mechanism in early Drosophila development.

6. Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.

Human Histone Deacetylase 3 (HDAC3) interaction partners

1. High activity of HDAC3 stabilizes c-Myc (v-myc myelocytomatosis viral oncogene homolog) protein by preferential deacetylation of cMyc at the K323 site, which contributes to the low pyruvate levels.

2. The HDAC3 mRNA was expressed more in glioma than in the normal glial cell line. Low HDAC3 mRNA expression levels predicted better overall survival.

3. in rheumatoid arthritis peripheral blood mononuclear cells, the activity and expression of HDAC3 is decreased, which is accompanied with enhanced histone acetyltransferase activity

4. High HDAC3 expression is closely correlated with ER-negative expression, PR-negative expression, HER2 overexpression, PT stage, and clinical stage of breast tumors.

5. these findings indicate that AKAP12 may be a potential prognostic predictor and therapeutic target for the treatment of colorectal cancer in combination with HDAC3

6. CHD5 was identified as a direct target of miR-454. CHD5 was downregulated in GC tissues/cell lines and the expresssion of CHD5 inversely correlated with the level of miR-454 in GC tissues. Taken together, these observations indicate that HDAC3 is associated with GC cell growth via the miR-454-mediated targeting of CHD5.

7. DANCR associated with EZH2 and HDAC3 to epigenetically silence lncRNA-LET and then regulated gastric cancer cells migration and invasion.

8. Data show there is allosteric communication between the inositol-binding site and the active sites in histone deacetylases HDAC1 and HDAC3.

9. Results show that proteasomal degradation of HDAC1 and HDAC3 by Vpr counteracts HIV-1 latency to reactivate the viral promoter.

10. the NCOR/HDAC3 complex is a major suppressor of differentiation in rhabdomyosarcoma

11. These findings indicate the importance of developing HDAC3-selective inhibitors, and their combined use with osimertinib, for treating EGFR-mutated lung cancers carrying the BIM deletion polymorphism

12. HDAC3-mediated p53 acetylation and oligomerization is induced by apoptosis caused by delphinidin in prostate cancer cells

13. Knockdown of either Xist or SPEN expression in breast cancer cells suppressed the expression of PHLPP1, a phosphatase in AKT dephosphorylation, and was correlated with increased HDAC3 recruitment to the PHLPP1 promoter.

14. Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.

15. Data show that the nuclear HDAC3 and cytoplasmic CDH1 have independent prognostic value in pancreatic cancer and provide targets for prognostic therapeutics.

16. HDAC3 uniquely primes Ucp1 and the thermogenic transcriptional program to maintain a critical capacity for thermogenesis in brown adipose tissue that can be rapidly engaged upon exposure to dangerously cold temperature

17. The low expression of HDAC3 and overexpession of inflammatory cytokines (IL-18, IL-12 and TNF-alpha) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.

18. SNP rs14251 was found to be significant (and rs2530223 to be nominally significantly associated with the increasing risk of SCZ susceptibility in Han Chinese individuals, suggesting this gene as a potential genetic modifier for SCZ development.

19. Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.

20. that histone deacetylase 3 interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment

Mouse (Murine) Histone Deacetylase 3 (HDAC3) interaction partners

1. Hdac3-KD results in pre-leukemia support the notion that HDAC3 could play an active role in acute promyelocytic leukemia onset and maintenance

2. ATXN3 positively regulates type I IFN antiviral response by deubiquitinating and stabilizing HDAC3

3. Schwann cell-specific deletion of either Hdac3 or Tead4 in mice resulted in an elevation of myelin thickness in sciatic nerves. Thus, our findings identify the HDAC3-TEAD4 network as a dual-function switch of cell-intrinsic inhibitory machinery that counters myelinogenic signals and maintains peripheral myelin homeostasis

4. Results show that deleting HDAC3 can ameliorate the impairments in both long-term memory and synaptic plasticity caused by BAF53b mutation. This suggests a dynamic interplay exists between histone acetylation/deacetylation and nucleosome remodeling mechanisms in the regulation of memory formation.

5. Therefore, Hdac3 is required for iNKT cell development and differentiation.

6. HDAC3 regulates multiple pathologies relevant for Alzheimer's disease. HDAC3 inhibition with RGFP-966 decreases pathological tau phosphorylation and acetylation, decreases beta-amyloid protein expression in the brain and periphery, increases beta-amyloid degradation in the periphery, and improves learning and memory in 3xTg-Alzheimer's disease mice and normalizes a number of Alzheimer's disease-related genes.

7. Nptx1, Hip1r, and Hdac9 as genes whose expression is altered by HDAC3.

8. This study highlights the novel mechanism of HDAC3-regulated Ucp1 expression during beta-adrenergic receptor stimulation.

9. Hdac3-depletion in osteoblasts increases expression of Opg, subsequently preserving insulin sensitivity.

10. HDAC3 plays an important role in regulating insulin secretion.

11. Epithelial HDAC3 promotes development of diet-induced obesity in studies of mice.

12. Hdac3 regulates distinct pathways in mesenchymal cell populations and is required for mesenchymal progenitor cell differentiation and long bone development.

13. Results suggest that the deacetylase domain of HDAC3 plays a selective role in specific brain regions underlying long-term memory formation of object location as well as cocaine-associated memory formation and extinction.

14. Reintroduction of wild-type Hdac3 restored normal B-cell development, whereas an Hdac3 point mutant lacking deacetylase activity failed to complement this defect. Thus, the deacetylase activity of Hdac3 is required for the generation of mature B cells.

15. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.

16. Selective HDAC3 inhibition effectively alleviated Klotho loss and kidney injury, whereas the protective effects were largely abolished when Klotho was knocked down by siRNA, suggesting that aberrant HDAC3 and Klotho loss are crucial components involved in the renal damage of mice with chronic kidney disease.

17. HDAC3 deletion displayed decreased pancreatic insulin content, disrupted glucose-stimulated insulin secretion, with intermittent spontaneous diabetes and dramatically enhanced susceptibility to STZ-induced diabetes.

18. Mice lacking HDAC3 in intestinal epithelial cells were more susceptible to Citrobacter rodentium. HDAC3 mediates communication between intestinal epithelial cells and resident lymphocytes.

19. Hepcidin expression involves epigenetic regulation by histone deacetylase 3.

20. HDAC3 interacts with PROX1.HDAC3 controls expression of genes regulating lipid homeostasis.

Zebrafish Histone Deacetylase 3 (HDAC3) interaction partners

1. HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development.

2. These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development.

Cow (Bovine) Histone Deacetylase 3 (HDAC3) interaction partners

1. The use of mesenchymal stem cells (MSC) less methylated and more hydroxymethylated in combination with embryo incubation with TSA can induce lower expression of HDAC3 and higher expression of KAT2A in the embryos and consequently improve bovine embryo production.

Xenopus laevis Histone Deacetylase 3 (HDAC3) interaction partners

1. Class I histone deacetylases regulate primitive hematopoiesis.