Browse our anti-HDAC3 (HDAC3) Antibodies

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 3 (HDAC3) interaction partners

1. Brm (show SMARCA2 Antibodies)-HDAC3-Erm (show MSN Antibodies) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.

2. Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.

3. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.

4. ) DHDAC1 (show HDAC1 Antibodies) and -3 have distinct functions in the control of gene expression

5. Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.

Human Histone Deacetylase 3 (HDAC3) interaction partners

1. the NCOR (show NCOR1 Antibodies)/HDAC3 complex is a major suppressor of differentiation in rhabdomyosarcoma

2. These findings indicate the importance of developing HDAC3-selective inhibitors, and their combined use with osimertinib, for treating EGFR (show EGFR Antibodies)-mutated lung cancers carrying the BIM (show BCL2L11 Antibodies) deletion polymorphism

3. HDAC3-mediated p53 (show TP53 Antibodies) acetylation and oligomerization is induced by apoptosis caused by delphinidin in prostate cancer cells

4. Knockdown of either Xist or SPEN (show SPEN Antibodies) expression in breast cancer cells suppressed the expression of PHLPP1 (show PHLPP1 Antibodies), a phosphatase in AKT (show AKT1 Antibodies) dephosphorylation, and was correlated with increased HDAC3 recruitment to the PHLPP1 (show PHLPP1 Antibodies) promoter.

5. Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.

6. Data show that the nuclear HDAC3 and cytoplasmic CDH1 (show CDH1 Antibodies) have independent prognostic value in pancreatic cancer and provide targets for prognostic therapeutics.

7. HDAC3 uniquely primes Ucp1 (show UCP1 Antibodies) and the thermogenic transcriptional program to maintain a critical capacity for thermogenesis in brown adipose tissue that can be rapidly engaged upon exposure to dangerously cold temperature

8. The low expression of HDAC3 and overexpession of inflammatory cytokines (IL-18 (show IL18 Antibodies), IL-12 (show IL12A Antibodies) and TNF-alpha (show TNF Antibodies)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.

9. SNP rs14251 was found to be significant (and rs2530223 to be nominally significantly associated with the increasing risk of SCZ susceptibility in Han Chinese individuals, suggesting this gene as a potential genetic modifier for SCZ development.

10. Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.

Mouse (Murine) Histone Deacetylase 3 (HDAC3) interaction partners

1. HDAC3 deletion displayed decreased pancreatic insulin content, disrupted glucose-stimulated insulin secretion, with intermittent spontaneous diabetes and dramatically enhanced susceptibility to STZ-induced diabetes.

2. Mice lacking HDAC3 in intestinal epithelial cells were more susceptible to Citrobacter rodentium. HDAC3 mediates communication between intestinal epithelial cells and resident lymphocytes.

3. Hepcidin (show HAMP Antibodies) expression involves epigenetic regulation by histone deacetylase 3.

4. HDAC3 interacts with PROX1 (show C16orf35 Antibodies).HDAC3 controls expression of genes regulating lipid homeostasis.

5. Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3 (show STAT3 Antibodies)) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3). (HDAC3) and caspase 3 (show CASP3 Antibodies).

6. The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 (show RAE1 Antibodies) family of NKG2D (show KLRK1 Antibodies) ligands. RAE-1 (show RAE1 Antibodies) is transcriptionally repressed by histone deacetylase (show HDAC1 Antibodies) inhibitor 3 (show PPP1R11 Antibodies) (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Antibodies) and preventing it from activating HDAC3.

7. Emerin (show EMD Antibodies)-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC (show MYH13 Antibodies)) expression and formed fewer myotubes. Emerin (show EMD Antibodies) binds to and activates histone deacetylase 3 (HDAC3).

8. Hdac3 is a key epigenetic modifier that maintains blood-lymph separation and integrates both extrinsic forces and intrinsic cues to regulate lymphatic valve development.

9. HDAC3 controls the temporal and spatial expression of tissue-remodeling genes and inflammatory responses in chondrocytes to ensure proper endochondral ossification during development.

10. HDAC3, through deacetylating tubulin (show TUBB Antibodies), promotes microtubule stability and the establishment of kinetochore-microtubule interaction, consequently ensuring proper spindle morphology, accurate chromosome movement and orderly meiotic progression during oocyte maturation

Zebrafish Histone Deacetylase 3 (HDAC3) interaction partners

1. HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development.

2. These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Antibodies) and hdac3 in zebrafish embryonic development.

Xenopus laevis Histone Deacetylase 3 (HDAC3) interaction partners