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Anti-MOG positive patients may have manifestations that mimic neuromyelitis optica spectrum disorders but differ in their course and prognosis from anti-AQP4 (show AQP4 Proteins) positive NMOSD.
Adoptive transfer of serum from anti-MOG Ab mice or of purified anti-MOG Ab 8.18C5 into naive 2D2 recipients triggered activation and expansion of T cells followed by severe and robust experimental autoimmune encephalomyelitis, suggesting that the mechanism of anti-MOG Ab-mediated opsonization of auto-antigen may indeed contribute to initiation and propagation of CNS demyelinating disease.
Retinal nerve fiber layer may be better preserved in MOG-IgG versus AQP4 (show AQP4 Proteins)-IgG optic neuritis.
Data show that aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG) autoantibodies double positive neuromyelitis optica spectrum disorder (NMOSD) patients had a multiphase disease course with a high annual relapse rate.
MOG antibody associated optic neuritis tends to involve the anterior optic pathway.
This study demonstrated that increased expression of mRNA of OLIG1 (show OLIG1 Proteins) in ventral prefrontal white matter in major depressive disorder.
In patients with idiopathic optic neuritis, 27.6% (8/29) were positive for MOG antibodies. Three of the eight MOG-positive patients showed significantly high CSF (show CSF2 Proteins) levels of myelin basic protein (show MBP Proteins). Five had optic pain and three had prodromal infection.
Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model.
These data demonstrate a new role for myelin glycosylation in the control of immune homeostasis in the healthy human brain through the MOG-DC-SIGN (show CD209 Proteins) homeostatic regulatory axis, which is comprised by inflammatory insults that affect glycosylation.
findings suggest that immune reactions toward MOG and in particular MOG-specific antibodies may play a functional role in multiple sclerosis
Identify nerve growth factor as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF (show NGFB Proteins) from TrkA (show NTRK1 Proteins)-expressing neurons to modulate axon growth and survival.
Data indicate that in mixed chimeras with bone marrow-encoding myelin oligodendrocyte glycoprotein (MOG), the development of MOG-specific B cells was abrogated, resulting in a lack of MOG-specific B cells in all B cell compartments examined.
Identify immunogenic/encephalitogenic T-cell epitopes within MOG capable of inducing experimental autoimmune encephalomyelitis in C57BL/6 mice.
PLP significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG)38-50-induced EAE model.
CNTF may play a role in the process of remyelination by inducing the MOG expression.
MOG-specific CD4 (show CD4 Proteins)-positive T cells accumulate within the chemokine (show CCL1 Proteins)-expressing draining lymph nodes, rather than within the brain or spinal cord during induction of autoimmune encephalomyelitis.
This study provides valuable information about requirements of anti-myelin oligodendrocyte glycoprotein reactivity for being regarded as a prognostic biomarker in a subtype of MS.
Mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein MOG(35-55) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression.
B cell-deficient mice exhibit reduced medullary thymic epithelial cell numbers and reduced MOG mRNA expression.
Cell surface targeting of MOG is not disrupted in the absence of the endoplasmic reticulum chaperones.
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
, MOG alpha-5
, myelin-oligodendrocyte glycoprotein
, oligodendrocyte-myelin glycoprotein
, dystonia 2, torsion (autosomal recessive)
, leucine-rich glycoprotein homolog
, oligodendrocyte myelin glycoprotein
, oligodendrocyte-myelin glycoprotein-like