Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Mouse (Murine) rala Antibodies:
anti-Rat (Rattus) rala Antibodies:
anti-Human rala Antibodies:
Go to our pre-filtered search.
RalA plays a crucial role in glucose transport in adipose tissue in vivo.
This study identifies a novel regulatory crosstalk between Ral and Arf6 (show ARF6 Antibodies) that controls Ral function in cells.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (show Ralb Antibodies).
RalA activation was remarkably impaired in rac1 (show RAC1 Antibodies)-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (show GRIN1 Antibodies)-long-term depression.
findings show either RALA or RALB (show Ralb Antibodies) is sufficient for tumor growth; either RALA or RALB (show Ralb Antibodies) is sufficient for cell proliferation; RALA and RALB (show Ralb Antibodies) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (show PPP1R3A Antibodies), RGC2 (show RALGAPA2 Antibodies)) that mediates the activation of RalA downstream of the PI 3 (show PI3 Antibodies)-kinase/Akt (show AKT1 Antibodies) pathway
A novel regulatory pathway involves RalA and phospholipase D (show PLD Antibodies) in the production of phosphatidic acid during Fc gamma receptor (show FCGR1A Antibodies)-mediated phagocytosis and phagosome formation.
RalA but not RalB (show Ralb Antibodies) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
In fact the overexpression of RalGPS2 (show RALGPS2 Antibodies) or of its PH-domain increased markedly the number and the length of nanotubes, while the knock-down of RalGPS2 (show RALGPS2 Antibodies) caused a strong reduction of these structures. Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5 (show EXOC2 Antibodies), Exo84 (show EXO84 Antibodies), RalBP1 (show RALBP1 Antibodies)) we demonstrated that the interaction of RalA with Sec5 (show EXOC2 Antibodies) is required for TNTs (show TNNI1 Antibodies) formation
Study explored the function of RalA in regulating the localization of AQP3 (show AQP3 Antibodies) in androgenindependent prostate cancer and demonstrated that depletion of RalA led to the redistribution of AQP3 (show AQP3 Antibodies) into the plasma membrane.
Data show that ras related GTP binding protein A (show RRAGA Antibodies) (Ral A) is necessary for 1-O-Hexadecyl-2-O-methyl-rac (show AKT1 Antibodies)-glycerol (HMG (show SSRP1 Antibodies))-mediated M phase arrest and induction of apoptosis in Nf1 (show NF1 Antibodies)-deficient cells.
High RalA expression is associated with chronic myelogenous leukemia.
This study demonstrated that RalA is overactivated in medulloblastoma.
Study shows the additional benefits of anti-RalA autoantibody as a potential serological biomarker for prostate cancer (PCa (show FLVCR1 Antibodies)), particularly in patients with normal PSA (show PLAG1 Antibodies), and further demonstrate the utility of biomarker combinations in the immunodiagnosis of PCa (show FLVCR1 Antibodies).
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (show RACGAP1 Antibodies) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Antibodies) and FilA but by stimulating PLD2 (show PLD2 Antibodies)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (show AK3 Antibodies)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A