Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with CD40

• CD40 molecule (CD40) antibody
• CD40 antigen (Cd40) antibody
• CD40 molecule (Cd40) antibody

• AI326936 antibody
• Bp50 antibody
• CDW40 antibody
• GP39 antibody
• HIGM1 antibody
• Show all synonym aliases
• IGM antibody
• IMD3 antibody
• p50 antibody
• T-BAM antibody
• Tnfrsf5 antibody
• TNFSF5 antibody
• TRAP antibody

Protein level used designations for CD40

B cell surface antigen CD40 , B cell-associated molecule , B-cell surface antigen CD40 , CD40 antigen (TNF receptor superfamily member 5) , CD40 type II isoform , CD40L receptor , nerve growth factor receptor-related B-lymphocyte activation molecule , tumor necrosis factor receptor superfamily member 5 , tumor necrosis factor receptor superfamily, member 5 , T-cell differentiation antigen , human CD40-homologue , CD40 antigen, TNF receptor superfamily member 5