Browse our anti-IL1A (IL1A) Antibodies

Human Interleukin 1 alpha (IL1A) interaction partners

1. IL1A SNPs play an essential role in upregulating cancer susceptibility

2. The expression of SOX9, IGF-1, IL-1alpha, and IL-6 in skin lesion tissues of patients with acne is increased, and SOX9 is positively correlated with IGF-1, IL-1alpha, and IL-6.

3. the pathway regulating the trafficking of IL-1alpha is distinct from the pathway regulating IL-1beta and IL-18. Although the release of IL-1alpha could also be dissociated from cell death, it was independent of the effects of the membrane-stabilizing agent punicalagin, which inhibited both IL-1beta and IL-18 release.

4. The expression levels of IL-1 and IL-18 of osteoporotic vertebral compression fracture patients were significantly higher than those in normal subjects

5. We focused on skin blotting using plasminogen activator inhibitor 1 (PAI1), interleukin-1alpha (IL-1alpha), vascular endothelial growth factor C (VEGF-C), and heat shock protein 90alpha (HSP90alpha). This pilot study was conducted at long-term-care and general hospitals to examine the applicability of DESIGN-R and thermography; the feasibility of skin blotting technique; the biomarker candidates, PAI1, IL-1alpha, VEGF-...

6. Proinflammatory interleukin 1 (IL-1(+)) genotypes modulate the risk of Lp(a) long-term cardiovascular disease (CVD) events and coronary artery disease (CAD).

7. IL1A polymorphism rs2856838 may contribute to risk of colorectal cancer in Han Chinese population; rs3783550, rs1609682, rs3783521 seem to be pathogenic variants for colorectal cancer in females.

8. Neutrophil extracellular traps promote endothelial cell activation and increased thrombogenicity through concerted action of IL-1alpha and cathepsin G and tissue factor production.

9. IL-1alpha and not IL-1beta is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue

10. signaling driven by HER2 promotes chronic inflammation needed to support cancer stem-like cell maintenance in HER2-positive breast cancers

11. Study shows reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression.

12. these results suggested that the activation of the expression of S100A8 induced by IL1a in TR146 epithelial cells involves a mechanism by which the binding activity of C/EBPB to the specific site (113/109) of the S100A8 promoter is increased.

13. IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.

14. Serum levels of IL-1alpha and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. IL-1alpha and IL-12 are good markers for monitoring liver disease progression in cirrhotic and diabetic Hepatitis C patients.

15. The present study finds that IL-1 alpha -899C/T polymorphism is associated with the risk of intervertebral disc degeneration.

16. Inflammatory cytokines interleukin (IL)-1alpha, IL-1beta and interferon-gamma-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota).

17. IL1A (-889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) and IL1B (-31C/T:rs1143627:T > C, -511C/T:rs16944C>T and +3954C/T:rs1143634:C > T) were genotyped through direct sequencing

18. Literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. For IL1A SNP, our hypothesis could not be confirmed.

19. T allele of 4845G>T associated with male infertility

20. Interleukin-1 alpha (IL-1alpha) can be expressed by epithelial tumor cells, from which it is either secreted or released upon necrotic cell death [Review].

Mouse (Murine) Interleukin 1 alpha (IL1A) interaction partners

1. the pathway regulating the trafficking of IL-1alpha is distinct from the pathway regulating IL-1beta and IL-18. Although the release of IL-1alpha could also be dissociated from cell death, it was independent of the effects of the membrane-stabilizing agent punicalagin, which inhibited both IL-1beta and IL-18 release.

2. this work identifies that MyD88-dependent activation of IL-1alpha in Kupffer cells plays a central role in the immunopathogenesis of acetaminophen-induced liver injury (AILI) and implicates that IL-1alpha is a promising therapeutic target for AILI treatment.

3. In mouse model of cerebral ischemia mannose binding lectin acts as an early trigger of platelet IL-1alpha release, which in turn favors MBL deposition on ischemic vessels promoting an endothelial pro-inflammatory phenotype.

4. IL-1alpha and not IL-1beta is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue

5. IL-1 alpha/beta plays a positive role in muscle regeneration by coordinating the initial interactions among inflammatory microenvironments and satellite cells.

6. The alarmin IL-1alpha released upon ozone-induced tissue damage and inflammation is mediated by MyD88 signaling in epithelial cells.

7. IL-1alpha is required for a downstream signaling cascade of innate immunity for efficient clearance of Brucella

8. early Aspergillus fumigatus fungal conidium germination drives greater lung damage and IL-1alpha-dependent inflammation

9. High Il-1a expression is associated with inflammation.

10. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 in multinucleated macrophages.

11. Together, these data suggest that caspase-11/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection.

12. These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression.

13. Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis.

14. Since neither IL-1alpha nor IL-1beta depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta have a similar and probably complementary role in FHF progression

15. These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.

16. In response to chemically induced colitis, this microbial landscape promoted the release of IL-1alpha, which acted as a critical driver of colitis and colitis-associated cancer.

17. our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.

18. Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.

19. endothelial cells were identified as the primary cellular source of G-CSF during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.

20. Key aspects of IL-1alpha biology and regulation especially with regard to inflammation are reviewed. Review.

Pig (Porcine) Interleukin 1 alpha (IL1A) interaction partners

1. Constitutive suppression of IL-1alpha maintains quiescence of endothelium and that terminal complement complexes remove that suppression, allowing IL-1alpha transcription and, ultimately, activation of endothelium to proceed.

Cow (Bovine) Interleukin 1 alpha (IL1A) interaction partners

1. These findings suggest that the elevated levels of IL-1alpha found in the osteoarthritis environment heighten fibroblast-like synoviocytes sensitivity to fluid shear by altering both intercellular communication and individual cell sensitivity, which could affect downstream functions and contribute to progression of the disease state

2. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.

3. Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

4. Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase.

5. non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties

6. These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells.

Rabbit Interleukin 1 alpha (IL1A) interaction partners

1. We propose that induction of collagenase-1 by IL-1alpha in both WF and NF depends on a unique combination of cell type-specific signaling pathways.