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anti-Human IL1A Antibodies:
anti-Mouse (Murine) IL1A Antibodies:
anti-Rat (Rattus) IL1A Antibodies:
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Mouse (Murine) Polyclonal IL1A Primary Antibody for IHC (p), WB - ABIN966393
Dinarello, Bunn: Fever. in Seminars in oncology 1997
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Mouse (Murine) Monoclonal IL1A Primary Antibody for ICS, Neut - ABIN2689744
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
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Human Monoclonal IL1A Primary Antibody for FACS - ABIN5502143
Foucher, Blanchard, Preisser, Descamps, Ifrah, Delneste, Jeannin: IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1α. in European journal of immunology 2015
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Human Monoclonal IL1A Primary Antibody for Inhibition, ICS - ABIN2689745
Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996
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Human Monoclonal IL1A Primary Antibody for ELISA, WB - ABIN1724632
Grimaldi, Casadei, Ferri, Veglia, Licastro, Annoni, Biunno, De Bellis, Sorbi, Mariani, Canal, Griffin, Franceschi: Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism. in Annals of neurology 2000
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Human Monoclonal IL1A Primary Antibody for IF, IHC - ABIN4324360
Archer, Jo, Lee, Kim, Smith, Ortines, Wang, Marchitto, Ravipati, Cai, Dillen, Liu, Miller, Ashbaugh, Uppal, Oyoshi, Malhotra, Hoff, Garza, Kong, Segre, Geha, Miller: Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release. in The Journal of allergy and clinical immunology 2018
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Cow (Bovine) Polyclonal IL1A Primary Antibody for WB - ABIN2785653
Ikeda, Sasazuki, Natsukawa, Shaura, Koizumi, Kasuga, Ohnami, Sakamoto, Yoshida, Iwasaki, Tsugane: Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. in The American journal of gastroenterology 2008
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Human Monoclonal IL1A Primary Antibody for FACS - ABIN4895759
Ong, Hadadi, Dang, Yeap, Tan, Ng, Larbi, Wong: The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. in Cell death & disease 2018
Human Polyclonal IL1A Primary Antibody for CyTOF, FACS - ABIN4900610
McCarthy, Clark, Bartling, Trebak, Melendez: Redox control of the senescence regulator interleukin-1? and the secretory phenotype. in The Journal of biological chemistry 2013
Rabbit Polyclonal IL1A Primary Antibody for ICC, IHC - ABIN1859376
Larrañaga-Vera, Lamuedra, Pérez-Baos, Prieto-Potin, Peña, Herrero-Beaumont, Largo: Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis. in Arthritis research & therapy 2017
IL1A SNPs play an essential role in upregulating cancer susceptibility
The expression of SOX9, IGF-1, IL-1alpha, and IL-6 in skin lesion tissues of patients with acne is increased, and SOX9 is positively correlated with IGF-1, IL-1alpha, and IL-6.
the pathway regulating the trafficking of IL-1alpha is distinct from the pathway regulating IL-1beta and IL-18. Although the release of IL-1alpha could also be dissociated from cell death, it was independent of the effects of the membrane-stabilizing agent punicalagin, which inhibited both IL-1beta and IL-18 release.
The expression levels of IL-1 and IL-18 of osteoporotic vertebral compression fracture patients were significantly higher than those in normal subjects
We focused on skin blotting using plasminogen activator inhibitor 1 (PAI1), interleukin-1alpha (IL-1alpha), vascular endothelial growth factor C (VEGF-C), and heat shock protein 90alpha (HSP90alpha). This pilot study was conducted at long-term-care and general hospitals to examine the applicability of DESIGN-R and thermography; the feasibility of skin blotting technique; the biomarker candidates, PAI1, IL-1alpha, VEGF-...
Proinflammatory interleukin 1 (IL-1(+)) genotypes modulate the risk of Lp(a) long-term cardiovascular disease (CVD) events and coronary artery disease (CAD).
IL1A polymorphism rs2856838 may contribute to risk of colorectal cancer in Han Chinese population; rs3783550, rs1609682, rs3783521 seem to be pathogenic variants for colorectal cancer in females.
Neutrophil extracellular traps promote endothelial cell activation and increased thrombogenicity through concerted action of IL-1alpha and cathepsin G and tissue factor production.
IL-1alpha and not IL-1beta is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue
signaling driven by HER2 promotes chronic inflammation needed to support cancer stem-like cell maintenance in HER2-positive breast cancers
Study shows reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression.
these results suggested that the activation of the expression of S100A8 induced by IL1a in TR146 epithelial cells involves a mechanism by which the binding activity of C/EBPB to the specific site (113/109) of the S100A8 promoter is increased.
IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.
Serum levels of IL-1alpha and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. IL-1alpha and IL-12 are good markers for monitoring liver disease progression in cirrhotic and diabetic Hepatitis C patients.
The present study finds that IL-1 alpha -899C/T polymorphism is associated with the risk of intervertebral disc degeneration.
Inflammatory cytokines interleukin (IL)-1alpha, IL-1beta and interferon-gamma-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota).
IL1A (-889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) and IL1B (-31C/T:rs1143627:T > C, -511C/T:rs16944C>T and +3954C/T:rs1143634:C > T) were genotyped through direct sequencing
Literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. For IL1A SNP, our hypothesis could not be confirmed.
T allele of 4845G>T associated with male infertility
Interleukin-1 alpha (IL-1alpha) can be expressed by epithelial tumor cells, from which it is either secreted or released upon necrotic cell death [Review].
this work identifies that MyD88-dependent activation of IL-1alpha in Kupffer cells plays a central role in the immunopathogenesis of acetaminophen-induced liver injury (AILI) and implicates that IL-1alpha is a promising therapeutic target for AILI treatment.
In mouse model of cerebral ischemia mannose binding lectin acts as an early trigger of platelet IL-1alpha release, which in turn favors MBL deposition on ischemic vessels promoting an endothelial pro-inflammatory phenotype.
IL-1 alpha/beta plays a positive role in muscle regeneration by coordinating the initial interactions among inflammatory microenvironments and satellite cells.
The alarmin IL-1alpha released upon ozone-induced tissue damage and inflammation is mediated by MyD88 signaling in epithelial cells.
IL-1alpha is required for a downstream signaling cascade of innate immunity for efficient clearance of Brucella
early Aspergillus fumigatus fungal conidium germination drives greater lung damage and IL-1alpha-dependent inflammation
High Il-1a expression is associated with inflammation.
Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 in multinucleated macrophages.
Together, these data suggest that caspase-11/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression.
Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
In response to chemically induced colitis, this microbial landscape promoted the release of IL-1alpha, which acted as a critical driver of colitis and colitis-associated cancer.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Key aspects of IL-1alpha biology and regulation especially with regard to inflammation are reviewed. Review.
Constitutive suppression of IL-1alpha maintains quiescence of endothelium and that terminal complement complexes remove that suppression, allowing IL-1alpha transcription and, ultimately, activation of endothelium to proceed.
These findings suggest that the elevated levels of IL-1alpha found in the osteoarthritis environment heighten fibroblast-like synoviocytes sensitivity to fluid shear by altering both intercellular communication and individual cell sensitivity, which could affect downstream functions and contribute to progression of the disease state
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells.
We propose that induction of collagenase-1 by IL-1alpha in both WF and NF depends on a unique combination of cell type-specific signaling pathways.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1 alpha
, interleukin 1-alpha
, precursor interleukin 1 alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha