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interleukin-1 receptor 1 (show IL1RL1 Proteins)/MyD88 (show MYD88 Proteins) signalling has roles in the development and progression of pulmonary hypertension
Study highlights the association of genetic polymorphisms of IL1R1 with knee osteoarthritis susceptibility in the Northwestern Chinese Han population.
Serum ST2 is elevated in heart failure patients and correlated with disease severity.
the IL-1 (show IL1A Proteins) receptor is translocated to lipid rafts where receptor endocytosis occurs to enable the internalization-dependent IL-1 (show IL1A Proteins) signaling to activate the IL-1 (show IL1A Proteins)-induced gene expression.
Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1 (show TNFRSF1A Proteins)), RIP1 (show UQCRFS1 Proteins), and IRAK1 (show IRAK1 Proteins), we hypothesize that SH exerts its NF-kappaB (show NFKB1 Proteins) activation inhibitory function by interacting with TNFR1 (show TNFRSF1A Proteins), interleukin-1 receptor type 1 (IL-1R1), and TLR3 (show TLR3 Proteins) complexes in the plasma membrane of infected cells.
ligand-activation of GPER generates a feedforward loop coupling IL1beta induction by CAFs to IL1R1 expression by cancer cells, promoting the up-regulation of IL1beta/IL1R1 target genes such as PTGES, COX2, RAGE and ABCG2
this study shows that IL-1a (show IL1A Proteins) gene variants are not associated with susceptibility to juvenile idiopathic arthritis in Iranian population
The work identifies a pathogenic role of postnatal IL1b (show IL1B Proteins)/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures, and highlights IL-1R1 as a potential therapeutic target for preventing the development of epilepsy after infantile febrile seizures.
The results present identification of critical regions within the TIR domain of IL-1 (show IL1A Proteins) receptor type in humans and mice.
IL1R1 (show IL1RN Proteins) SNP rs949963 is associated with the susceptibility to asthma in children from Central China and may increase the serum expression of IL1R1 (show IL1RN Proteins).
The present study demonstrates a novel mechanism underlying LPS (show TLR4 Proteins)-induced innate immunity; that is, a secondary upregulation of IL-1beta (show IL1B Proteins)-IL-1RI signaling is responsible for alveolar macrophages pyroptosis and augmented lung injury in response to LPS (show TLR4 Proteins).
Study conclude that while interleukin-1 signaling is not critical for lipopolysaccharide induced anorexia or stress hormone release, interleukin-1 type 1 receptor expressed on brain endothelial cells, contributes to the febrile response to lipopolysaccharide.
Data indicate that IL-1RI and TNF (show TNF Proteins)-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected.
These results suggest that cytokines, particularly IL-1 (show IL1A Proteins), areassociated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine (show CCL1 Proteins) production.
Using respective knockout mice it was found that LPS (show TLR4 Proteins)-mediated GIP (show GIP Proteins) secretion was selectively dependent on IL-1 (show IL1A Proteins) signalling.
Results demonstrated the essential role of IL-1R1 in kindling-induced sleep disturbance by using transgenic IL-1R1 KO mice. Epilepsy-induced sleep disturbances were absent in the IL-1R1 KO mice, indicating the importance of IL-1 (show IL1A Proteins) signals. The knockout of IL-1R1 did not change the seizure thresholds, suggesting that IL-1R1 signaling is not in involved in the kindling-induced epileptogenesis.
findings show elements of the IL-1 (show IL1A Proteins) network, including IL-1alpha, IL-1beta (show IL1B Proteins), and IL-1R1, are essential for the optimal host response to VACV cutaneous infection
These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88 (show MYD88 Proteins), and is not sufficient to prevent bacterial binding.
IL-1R1 signaling via MyD88 (show MYD88 Proteins) is critical for the first step of inflammatory response to papain.
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
CD121 antigen-like family member A
, antigen CD121a
, interleukin 1 receptor alpha, type I
, interleukin receptor 1
, interleukin-1 receptor alpha
, interleukin-1 receptor type 1
, interleukin-1 receptor type I
, IL-1 receptor alpha chain
, interleukin 1 beta receptor type 1 short transmembrane form
, interleukin 1 beta receptor type 1 soluble form
, interleukin 1 bete receptor type 1 long transmembrane form