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Data indicate the association between genetic polymorphisms of interleukin 1 receptor type 1 (IL1R1) and interleukin 1 receptor type 2 (IL1R2) and tuberculosis (TB) susceptibility in the Chinese Han population. IL1R1 and IL1R2 and TB susceptibility in the Chinese Han population.
rs3218977-GG was associated with a decreased risk of lung cancer in Chinese population. rs2072472 had a significant risk-increasing effect in the dominant model.
Two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk in Chinese population.
rs11674595 was significantly associated with the risk of femur head osteonecrosis in the Chinese Han population.
rs2072472 was significantly associated with a 0.73-fold decreased risk of high-altitude pulmonary edema.
Plasma levels of soluble IL-1R2 are independently associated with parameters of left ventricular adverse remodeling following ST-elevation myocardial infarction.
IL1R2 SNPs rs719250 and rs3218896 are significantly associated with cervical cancer risk among Uygur females from China.
The expression of SLC22A4, IL1R2 and VNN3, were independently associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure patients.
these results reveal that the IL-1/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of ulcerative colitis patients
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD.
present study demonstrated the ability of Staphylococcus aureus to induce IL-1RII shedding in myeloid cells
Expression level of IL1R2 was down regulated in cervical squamous cell carcinoma.
reduced risk of preterm birth in Indian women with the minor allele of rs2072476 polymorphism
No significant differences in the lymphocyte mRNA levels of IL-1R2, IL-6R, and Gp130 were observed between MDD patients and NC. These studies suggest abnormal gene expression of these cytokines and their membrane-bound receptors in the lymphocytes of MDD patients, and that their mRNA expression levels in the lymphocytes could be a useful biomarker for depression.
IL1R2 rs2310173 genotype GT was mildly protective against ankylosing spontylitis only in HLA-B27-negative patients.
IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with ankylosing spondylitis in Northern Han Chinese.
Suggest IL-1R2 as potential biomarker of acute respiratory distress syndrome.
Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6) and vascular endothelial growth factor A (VEGF-A) promoters.
Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6, levels were positively correlated with a composite measure of aggression.
Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway.
Il1r2 encourages STAT3 to bind to cis-elements that regulate expression of interleukin-17.
Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta-induced AMP production.
Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1- and neutrophil-dependent tissue inflammation
Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17) regulates interleukin (IL)-1 signaling via cleavage of IL-1 receptor type 2 (IL-1R2).
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Interleukin-1 receptor type II is significantly upregulated in decidual cells close to the embryo during days 5 to 8 of pregnancy.
neutrophils mainly express the decoy receptor IL-1R2 under naive and inflammatory conditions.
Data show that bee venom detected by inflammasome and trigger activation of caspase-1 and secretion of proinflammatory cytokine IL-1beta is pyrin domain-containing 3 NLRP3, apoptosis-associated speck-like protein ASC, and IL-1 receptor dependent.
inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss
BACE1 and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP
ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
CD121 antigen-like family member B
, IL-1 type II receptor
, antigen CDw121b
, interleukin 1 receptor type II variant 3
, interleukin-1 receptor beta
, interleukin-1 receptor type 2
, interleukin-1 receptor type II
, type II interleukin-1 receptor, beta
, IL-1 receptor beta chain
, soluble type II IL-1 receptor
, interleukin 1 receptor, type II
, IL-1 receptor 2
, interleukin 1 receptor, beta