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Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN988011
Dayer, Chicheportiche, Juge-Aubry, Meier: Adipose tissue has anti-inflammatory properties: focus on IL-1 receptor antagonist (IL-1Ra). in Annals of the New York Academy of Sciences 2006
Show all 3 Pubmed References
Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN988019
Hedl, Abraham: Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. in Gastroenterology 2012
Human IL1RN Protein expressed in Wheat germ - ABIN1307765
OShaughnessy, Choudhary, Harper: Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis. in Human molecular genetics 2010
Mouse (Murine) IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN5571020
Hunt, Xu, Finkelstein, Fan, Carroll, Cheng, Eisenman, Demontis: The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. in Genes & development 2015
Studies used adult stem cells to engineer anatomically shaped, functional cartilage constructs capable of tunable and inducible expression of antiinflammatory molecules, specifically IL-1 (show IL1A Proteins) receptor antagonist (IL-1Ra).
No significant associations with RHD were found for the IL1RN rs447713 and CTLA4 (show CTLA4 Proteins) rs3087243 SNPs.
Reconstitution of ST2 (show SULT2A1 Proteins) (IL-1R4) specific for IL-33 (show IL33 Proteins) activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP (show IL1RAP Proteins)) shared with IL-1 (show IL1A Proteins)
The polymorphic expression of IL-1RN (rs419598) gene may be associated with a reduced susceptibility to GAgP and GCP in populations of European descent.
associations between the genetic variants and the LPS (show IRF6 Proteins)-induced IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), IL-10 (show IL10 Proteins), IL-1ra and TNF-alpha (show TNF Proteins) cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS (show IRF6 Proteins)-stimulated cytokine production; however, the potential for type II errors should be considered
IL1RA intron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.
Increased IL-1Ra levels in women with polycystic ovary syndrome were largely explained by increasing adiposity. However, serum IL-1Ra concentrations predicted 2-h glucose levels independently of BMI suggesting that increased IL-1Ra may be associated with disturbed glucose metabolism.
demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians
Polymorphisms of Il1rn were not significantly associated with bipolar I disorder in Iranian patients.
Meta-analysis: Serum IL-1RA levels were positively associated with risk of cardiovascular disease. This association may at least partially reflect a response to triggers inducing subclinical inflammation, oxidative stress, and endothelial activation.
This study identified IL-1Ra as an early immunomodulatory mediator that could be involved in the immunopathogenesis of porcine reproductive and respiratory syndrome virus infections.
The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.
common variation across the IL-1RN gene is strongly associated with IL-1RA levels.
Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 (show IL1A Proteins) signal transduction and thereby plays an important role in the establishment of equine pregnancy.
Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 (show TLR4 Proteins) in mucosal Th17 cell induction associated with the development of autoimmune disease in mice.
Following vasectomy, IL1alpha (show IL1A Proteins), IL1beta (show IL1B Proteins), IL1ra, IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 (show IL6 Proteins) and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia.
the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta (show IL1B Proteins) and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas
we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells.
results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo.
Allo-transplantation of mesenchymal stem cells reduces Con (show KITLG Proteins) A liver injury by increasing IL10 (show IL10 Proteins) production through an IL1Ra dependent macrophage switch.
results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 (show NLRC4 Proteins) contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4 (show NLRC4 Proteins)-dependent IL-1Ra production.
IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE (show APOE Proteins)(-/-) mice.
IL-8 (show IL8 Proteins) and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, IL1RN (IL1F3)
, interleukin-1 receptor antagonist protein
, intracellular IL-1 receptor antagonist type II
, intracellular interleukin-1 receptor antagonist (icIL-1ra)
, type II interleukin-1 receptor antagonist
, interleukin 1 receptor antagonist
, interleukin-1 receptor antagonist secretory form
, secretory interleukin-1 receptor antagonist
, IL-1 receptor antagonist