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Rat (Rattus) Insulin Receptor ELISA Kit for Sandwich ELISA - ABIN431588
El-Far, Zakaria, Gabr, El Gayar, El-Sherbiny, Eissa: A newly developed silymarin nanoformulation as a potential antidiabetic agent in experimental diabetes. in Nanomedicine (London, England) 2016
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Mouse (Murine) Insulin Receptor ELISA Kit for Sandwich ELISA - ABIN424255
Ide, Arisawa, Ogura, Kagawa, Maeda: Age-Dependent Onset of Insulin Resistance in Insulin-Resistant Mice. in Biological & pharmaceutical bulletin 2015
Show all 2 Pubmed References
The IGF1R (show IGF1R ELISA Kits) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Signaling via the insulin (INS (show INS ELISA Kits)) and insulin-like growth factor 1 (IGF1 (show IGF1 ELISA Kits)) receptors (INSR and IGF1R (show IGF1R ELISA Kits)) regulate basal cell (BC) differentiation into ciliated cells.
High INSR expression is associated with drug Resistance in Gastrointestinal Stromal Tumors.
the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin (show INS ELISA Kits) signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis.
Activation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension.
The HIR (show KCNJ4 ELISA Kits) MAb binds the insulin receptor on the BBB (show ALMS1 ELISA Kits).
data indicate that post-receptor signalling abnormalities might contribute to Myotonic dystrophy insulin (show INS ELISA Kits) resistance regardless the alteration of INSR splicing.
We identified vascular INSR expression as a potential biomarker for progression in bladder cancer. The data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target.
The INSR rs2059806 SNP is associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases.
IGF2 and insulin receptor A are important for uterine leiomyoma stem cell proliferation and may represent paracrine signaling between leiomyoma cell types.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (show IGF1R ELISA Kits) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 ELISA Kits)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (show PRKCE ELISA Kits) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (show INS ELISA Kits) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (show AGRP ELISA Kits) neurons (AgRP (show AGRP ELISA Kits) IR KO) exhibited impaired hepatic insulin (show INS ELISA Kits) action because the ability of insulin (show INS ELISA Kits) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (show INS ELISA Kits) to suppress lipolysis was unaltered. To the contrary, in POMC (show POMC ELISA Kits) IR KO mice, insulin (show INS ELISA Kits) lowered hGP but failed to suppress adipose tissue lipolysis.
Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (show TXLNA ELISA Kits), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.
Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB ELISA Kits) inhibition required the expression and activation of the insulin receptor (IR)/insulin (show INS ELISA Kits) growth-like factor receptor (IGF1R (show IGF1R ELISA Kits)) for tumor cell proliferation and survival.
The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (show GIP ELISA Kits) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (show INS ELISA Kits)-resistant states.
In conclusion, we have identified that ARL15 acts as an insulin (show INS ELISA Kits)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 ELISA Kits)/PDPK1 (show PDPK1 ELISA Kits)/AKT (show AKT1 ELISA Kits) insulin (show INS ELISA Kits) pathway by interacting with its GAP ASAP2 (show ASAP2 ELISA Kits) and activating PDPK1 (show PDPK1 ELISA Kits). This research may provide new insights into GTPase (show RACGAP1 ELISA Kits)-mediated insulin (show INS ELISA Kits) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS ELISA Kits) sensitizati
Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a (show PPP2R2A ELISA Kits)). Inheritance of either allele results in insulin (show INS ELISA Kits) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS ELISA Kits) resistance and diabetes type 2 without increase in body weight.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (show CTSA ELISA Kits) biosynthesis, prevents inappropriate activation of insulin (show INS ELISA Kits) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 ELISA Kits), IGF-2, IGFBP-2 (show IGFBP2 ELISA Kits), IGFBP-3 (show IGFBP3 ELISA Kits), IGF-1R (show IGF1R ELISA Kits), IGF-2R, GHR (show GHR ELISA Kits), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (show BRD2 ELISA Kits), but not E2, stimulated the expression of IR and GHR (show GHR ELISA Kits) genes during follicular development.
Data conclude that insulin (show INS ELISA Kits) and IGF-I (show IGF1 ELISA Kits) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit