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The LIGHT (Tumour necrosis factor (show TNF Proteins) ligand superfamily member 14, TNFSF14 (show TNFSF14 Proteins))/Lymphotoxin beta-Receptor(LTbeta (show LTB Proteins)-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE (show APOE Proteins)-/-Irs2 (show IRS2 Proteins)+/-HL-/- atheromas.
EAE induced by weak activation of innate immunity requires the NLRP3 inflamma (show CXCR4 Proteins)some and (show CXCR2 Proteins)is sensitive to interferon-beta treatment
lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7 (show IL7 Proteins); the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (show LTB Proteins) (LT)betaR signaling
LTbetaR is essential for efficient liver regeneration and cooperates with TNFRp55 (show TNFRSF1A Proteins) in this process. Differences in survival kinetics strongly suggest distinct functions for these two cytokine receptors in liver regeneration.
DC-derived LTBR ligands are critical mediators of lymph node cells survival, and LTBR signaling on reticular stromal cells is mediated by Pdpn (show PDPN Proteins) expression.
LTbR plays a role in macrophage-driven inflammation in atherosclerotic lesions from ApoE (show APOE Proteins) knockout mice, probably by augmenting the Ccl5 (show CCL5 Proteins)-mediated recruitment of monocytes.
M1 macrophages as inducer cells that trigger the expression of chemokines by vascular smooth muscle cell independently of lymphotoxin beta receptor signalling
lymphotoxin beta receptor regulates the development of the CCL21 (show CCL21 Proteins)-expressing subset rather than the Aire (show AIRE Proteins)-expressing subset of postnatal Medullary thymic epithelial cells.
LTbetaR activation on macrophages by T cell-derived lymphotoxin alpha(1)beta(2) controls proinflammatory responses by activation of a TRIM30alpha-controlled, counterregulatory signaling pathway to protect against exacerbating inflammatory reactions.
LTbetaR signaling in gut (show GUSB Proteins) lymphoid follicles regulates IL-22 (show IL22 Proteins) production by innate lymphoid cells in response to mucosal pathogen challenge.
membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor (show CXCR4 Proteins) 2 (CXCR2 (show CXCR2 Proteins)), is involved in type B EAE development
LIGHT and LTBR interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy.
We found that LTbetaR polymorphisms caused severe BPH (show GLI3 Proteins). Thus, LTbetaR may contribute to the risk of BPH (show GLI3 Proteins) development.
activation enhances the LPS (show IRF6 Proteins)-induced expression of IL-8 (show IL8 Proteins) through NF-kappaB (show NFKB1 Proteins) and IRF-1 (show IRF1 Proteins)
LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine (show CCL1 Proteins) production by bronchial epithelial cells.
Relative expression of HVEM (show TNFRSF14 Proteins) and LTbetaR modulates canonical NF-kappaB (show NFKB1 Proteins) and pro-apoptotic signals stimulated by LIGHT.
lymphotoxin-B (show LTB Proteins)-specific receptor.
LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children
Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 (show ITGAM Proteins) and Bcl-2 (show BCL2 Proteins)/Bax (show BAX Proteins) expression in blood leukocytes and improves microcirculatory status in aged patients with kidney deficiency and blood stasis syndrome.
show that a cognate interaction between LTalphabeta on CD4 (show CD4 Proteins)(+) helper T cells and LTbeta (show LTB Proteins) receptor on DCs results in unique signals that are necessary for optimal CD8 (show CD8A Proteins)(+) T-cell expansion via a type I IFN-dependent mechanism
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
lymphotoxin B receptor
, tumor necrosis factor receptor superfamily member 3
, LT beta-R
, LT-beta receptor
, TNF receptor-related protein
, lymphotoxin-beta receptor
, tumor necrosis factor receptor superfamily, member 3
, tumor necrosis factor C receptor
, tumor necrosis factor receptor 2-related protein
, tumor necrosis factor receptor type III