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anti-Human p65 Antibodies:
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Human Polyclonal p65 Primary Antibody for ICC, IHC (p) - ABIN3044253
Kan, Zhou, Jin, Yang: Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury. in International journal of clinical and experimental medicine 2015
Show all 50 Pubmed References
Mouse (Murine) Polyclonal p65 Primary Antibody for WB - ABIN3043315
Li, Chu, Gao, Li: Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin. in Acta biochimica et biophysica Sinica 2009
Show all 46 Pubmed References
Human Polyclonal p65 Primary Antibody for WB - ABIN3042741
Leng, Liu, Yang, Cui, Li, Zhu, Xiong, Zhang, Chen: The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells. in Cell biology international 2012
Show all 46 Pubmed References
Human Polyclonal p65 Primary Antibody for ELISA, IHC (p) - ABIN5693244
Zhang, Chen, Xin, Li, Li, Lin, Geng, Ding: Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation. in Acta pharmacologica Sinica 2010
Show all 45 Pubmed References
Human Polyclonal p65 Primary Antibody for WB - ABIN3043699
Ni, Wang, Yan, Tian, Zhao, Wang, Jiang: Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice. in Respiratory research 2010
Show all 43 Pubmed References
Human Polyclonal p65 Primary Antibody for FACS, IF (p) - ABIN668961
Jiang, Tian, Fu, Zhu, Hou: Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. in European journal of pharmacology 2010
Show all 29 Pubmed References
Human Polyclonal p65 Primary Antibody for ICC, IF - ABIN151596
Starkey, Haidacher, LeJeune, Zhang, Tieu, Choudhary, Brasier, Denner, Tilton: Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex. in Diabetes 2006
Show all 29 Pubmed References
Human Polyclonal p65 Primary Antibody for GS, WB - ABIN233796
Lou, Kaplowitz: Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. in The Journal of biological chemistry 2007
Show all 20 Pubmed References
Human Polyclonal p65 Primary Antibody for ELISA, ICC - ABIN6263616
Yu, Li, Liu, Tian, Yuan, Bai, Wang, Zhang, Ren, Zhang, Li: Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. in International immunopharmacology 2015
Show all 14 Pubmed References
Human Polyclonal p65 Primary Antibody for IHC, IP - ABIN6711852
Chen, Zhang, Shen, Wang: Effects of the acid polysaccharide fraction isolated from a cultivated Cordyceps sinensis on macrophages in vitro. in Cellular immunology 2010
Show all 12 Pubmed References
study illustrates a novel mechanism of p68 mediated deployment of beta-catenin in RelA gene regulation eventually leading to activation and recruitment of NF-kappaB signaling axis in the cell survival pathway for promoting tumorigenesis.
DNA methylation profiling helped in the differential diagnosis of RELA-fused ependymomas.
Nuclear p65 expression identifies prostate cancer patients with an increased risk of developing bone metastases and PC-specific mortality.
This study highlighted a critical role of TREM2 in regulating cell viability, apoptosis, and inflammatory response in both degenerative nucleus pulposus cells and human normal nucleus pulposus cells and revealed the involvement of transcriptional regulation of NF-kappaB p65 in this process.
the non-small cell lung cancer (NSCLC) cells within miR-7 + RELA group were observed with superior proliferative, migratory and invasive capabilities than those within miR-7 group (P < .05), and RELA expression was also significantly modified by both ciRS-7 and miR-7 (P < .05). In conclusion, the ciRS-7/miR-7/NF-kB axis could exert pronounced impacts on the proliferation, migration, invasion and apoptosis of NSCLC cells.
The binding ability of NF-kappaB to p52/RelB was increased during the progression of cervical cancer. All cervical carcinoma biopsies showed increased expression of p50/RelA and p52/RelB, but the p52/RelB NF-kappaB protein complex showed elevated nuclear expression and binding ability, indicating a pathway other than the classical pathway.
silencing PHACTR1 alleviates the nuclear accumulation of p65 and NF-kappaB via interaction with MRTF-A, ensuing attenuating oxidative stress and inflammation in human coronary artery endothelial cells
highly expressed ANRIL also notably bring down miR-181b expression and raise p50/p65 expressions within HCAECs (P < 0.05). The joint role of ANRIL, miR-181b and NF-kappaB signalling could aid in further treating and diagnosing coronary artery disease.
KLF14 inhibits the inflammatory response in endothelial cells; its protective effects are mediated by transcriptional inhibition of NF-kappaB p65
Nrf2 prevents inflammation caused by layer house PM2.5 stimulation, however, autophagy exerts a promotive role in TLR4 - NFkappaB p65 mediating inflammation in A549cell.
RELA is functionally important target gene of METTL3 in bladder cancer.
we show that NF-kappaB-p65 is a key player in neuroprotection of human neurons, however the protective gene expression program beneath it differs between sexes
Study identified the association of the HIV-2-encoded Vpx with the transcription factor RelA (also called p65) and documented a functional relevance for this interaction in antagonizing NF-kappaB-driven gene expression. The mutation of the DDB1 binding interface of HIV-2-encoded Vpx significantly impaired NF-kappaB inhibition, indicating that Vpx counteracts NF-kappaB signaling by a DDB1- and CRL-dependent mechanism.
Co-expression of p65 and phosphorylated p105 but not of either p65 or phosphorylated p105 alone was associated with a poor prognosis in surgically resectable non-small cell lung cancer patients.
TCL1A also acts as a transcriptional coregulator with NF-kappaB p65
DNA fragment with the most GGAAs showed the highest binding affinity to NF-kappaB dimers.
Ectopic expression of RELA influenced the interactome of nuclear ACTN4, which is the RelA/p65 co-activator.
in RelA high conditions, low Nrf2 and lack of cxcr5 promoter DNA-methylation govern CXCL13-CXCR5 co-expression within breast tumors, and thus drive disease progression and metastasis.
During Fusobacterium nucleatum infection transcription factor NF-kappaB nuclear translocation is regulated by NOD-like receptor X1 (NLRX1). NLRX1-deficient cells show increased NF-kappaB levels in the nucleus, but reduced NF-kappaB in the cytosol during infection, compared to wildtype cells. NLRX1 dampens cytokine production during F. nucleatum infection by down regulating nuclear translocation of NF-kappaB.
A total of 688 common DEGs were identified between survivors and non-survivors of sepsis, and 96 genes were involved in survival networks. The crucial genes Signal transducer and activator of transcription 5A (STAT5A), CCAAT/enhancer-binding protein beta (CEBPB), Myc proto-oncogene protein (MYC), and REL-associated protein (RELA) were identified and showed increased expression in sepsis survivors.
The role of the PI3K/Akt/mTOR pathway in inflammatory regulation is independent of the activation of TLRs/NF-kappaB. Cross-talk between PI3K/Akt/mTOR and TLRs/NF-kappaB signaling pathways promote inflammation.
PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells.
Results showed that the secretion and expression of inflammatory cytokines increased in a dose-dependent manner in response to acetoacetate and glucose; both drugs also upregulated NF-kappa B p65 and Ikappab-alpha phosphorylation levels.
Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB signaling pathway.
The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-kappaB activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response,induction of IL-8 and TNFalpha, in the udder
These results confirm that VEGI utilizes NF-kappaB as a pro-survival role factor in endothelial cells.
NF-kappaB activation was a major contributor to Porcine transmissible gastroenteritis virus infection-induced inflammation, and nonstructural protein 2 (Nsp2) was the key viral protein involved in the regulation of inflammation, with amino acids 1-120 playing a critical role in activating NF-kappaB.
TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication via activation of NF-kappaB-signaling pathways.
NF-kappaB signaling pathway was activated by transmissible gastroenteritis virus infection.NF-kappaB has 4 binding sites in the FcRn promoter.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB.
Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
of pp65RHD spatiotemporal expression system is helpful to regulate NFsmall ka, CyrillicB activity and conquer cell-mediated immunity and could be used for preparation of transgenic pig, contributing to xenotransplantation.
Classical swine fever virus failed to activate nuclear factor-kappa b signaling.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB p65 subunit (pp65), is reported.
NFKB activation may occur during the period of uterine receptivity in both cyclic and pregnant endometrium.
Viral non-structural protein 1 suppressed host TNF-alpha promoter by inhibiting NF-kappaB and Sp1 promoter binding activity.
requirement of RelA-dependent inducible hepatoprotection during pneumonia and sepsis.
the results of the present study demonstrated that miRNA302e attenuated inflammation in IP through the RelA/ BRD4/ NFkappaB signaling pathway.
These data suggest that theophylline has an anti-inflammatory effect on skeletal muscle in a mouse model of emphysema by upregulating HDAC2 expression and decreasing NF-kappaBp65 activation.
findings reveal that oridonin protects against OVX-induced bone loss via inhibiting osteoclastic bone resorption but enhancing osteoblastic bone formation through abolishing both Ifrd1-mediating and IkappaBalpha-mediated p65 nuclear translocation.
present study characterized a novel physiological role of CCRP in protecting cardiac functions through the inhibition of NFkappaB signaling.
RelA-BRD4 signaling in distal tracheobronchiolar epithelial cells mediates acute inflammation in response to luminal viral patterns.
Cell-permeable SBD peptide blocked the association of p65 with Smad4 and enhanced BMP2-induced osteoblast differentiation and mineralization.
The study suggests that targeting MIAT may protect against cardiomyocytes against hypoxia-reperfusion injury or myocardial ischemia-reperfusion injury via inhibition of cell apoptosis, mediated by NF-kappaB and PUMA signaling pathway.
role of NF-kappaB in the upregulation of cystathionine-gamma-lyase in bladder pain accompanying cystitis
Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-kappaB and p53 signaling pathways
Further analysis revealed that Edwardsiella piscicida phosphothreonine lyase promotes the dephosphorylation and ubiquitination of p65 by inhibiting the phosphorylation of mitogen- and stress-activated protein kinase-1 (MSK1) and by inhibiting the phosphorylation of extracellular signal-related kinase 1/2 (ERK1/2), p38alpha, and c-Jun N-terminal kinase (JNK).
western blot results indicated that SH suppressed the phosphorylation of nuclear factor kappalightchainenhancer of activated Bcells (NFkappaB) p65 protein and reduced the degradation of inhibitor of kappa light polypeptide gene enhancer in Bcells alpha protein in vivo and in vitro.
Results show that the DNA-binding cavity in the RelA-p50 heterodimer is open for DNA binding, whereas in the RelA homodimer, it is occluded.
Deficiency in MyD88 was associated with decreased BDNF expression. Furthermore, the authors identified a valid kappaB-binding site in the BDNF promoter, consistent with activation of NF-kappaB induced by inflammation.
Zbtb7a binds to a significant fraction of genomic promoters and enhancers, encompassing many target genes of nuclear factor kappa B p65 .
High NRP1 expression promotes esophageal squamous cancer progression.
Rela and Traf3 were both targeted by miR-155-5p.
The mechanism of NLRP3 activation in Kupffer cells of liver fibrosis induced by schistosomiasis japonica was shown to be via NF-kappa B metabolism.
Studied anti-inflammatory effects of ethyl acetate extracts of E. sagittatum (Ying-Yang-Huo) and found it to inhibit toll-like receptor 4(TLR4)/ lymphocyte antigen 96(MD-2) thru the NF-kappaB signal pathway.
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
C-Rel proto-oncogene protein
, oncogene REL, avian reticuloendotheliosis
, proto-oncogene c-Rel
, v-rel reticuloendotheliosis viral oncogene homolog
, NF-kappa-B p65delta3
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, C-Rel protein
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit
, reticuloendotheliosis oncogene
, v-rel avian reticuloendotheliosis viral oncogene homolog
, LOW QUALITY PROTEIN: proto-oncogene c-Rel