Browse our anti-TRADD (TRADD) Antibodies

Human TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

1. In conclusion, for the first time, we report that TRADD, TRAF2 (show TRAF2 Antibodies), RIP1 (show UQCRFS1 Antibodies) and TAK1 (show MAP3K7 Antibodies) play a role in the regulating TNF-alpha (show TNF Antibodies) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (show TNF Antibodies) in the processes of human labour and delivery.

2. These data for the first time identifies miR (show MLXIP Antibodies)-485-5p/TRADD axis in hydrogen sulfide (show SQRDL Antibodies) protecting against TNF-alpha (show TNF Antibodies)-induced neuronal cell apoptosis.

3. By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling.

4. NPM (show NPM1 Antibodies)-RAR (show RARA Antibodies) binding to TRADD selectively inhibits caspase (show CASP3 Antibodies) activation, while allowing activation of NFkappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies)

5. The release of extracellular vesicles was triggered by TNFA (show TNF Antibodies) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (show TNFRSF1A Antibodies) and TRADD.

6. MicroRNA-30c-2-3p negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (show CCNE1 Antibodies) in breast cancer.

7. domains of calmodulin mediate FADD (show FADD Antibodies) and TRADD interaction

8. PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (show TNFRSF1A Antibodies)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (show TNFRSF1A Antibodies)/RIP (show HRB Antibodies)/NF-kappaB (show NFKB1 Antibodies) 50/NF-kappaB (show NFKB1 Antibodies) 65).

9. Biologic assessment found that NPM (show NPM1 Antibodies)-RAR (show RARA Antibodies) expression impaired TNF (show TNF Antibodies)-induced signaling through TRADD, blunting TNF (show TNF Antibodies)-mediated activation of caspase-3 (CASP3 (show CASP3 Antibodies)) and caspase-8 (CASP8 (show CASP8 Antibodies)), to ultimately block apoptosis.

10. TRADD gene expression was knocked down by an antisense oligonucleotide.

Mouse (Murine) TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

1. TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 Antibodies)/p38 MAPK (show MAPK14 Antibodies) but not AKT (show AKT1 Antibodies) phosphorylation

2. Data indicate that ASK1 (show MAP3K5 Antibodies) activation stimulated the activity of the transcription factor FoxO3a (show FOXO3 Antibodies), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (show CASP8 Antibodies).

3. data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression

4. Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (show NFKB1 Antibodies) activation.

5. TRADD is required for recruitment of receptor interacting protein 1 (show RIPK1 Antibodies) and TNFR (show TNFRSF1A Antibodies)-associated factor 2 to the DR3 (show TNFRSF25 Antibodies) signaling complex and for the ubiquitination of receptor interacting protein 1 (show RIPK1 Antibodies)

6. We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (show RALBP1 Antibodies) recruitment is mediated by TRADD.

7. TRADD may be involved in IFN-gamma (show IFNG Antibodies) signaling by forming a complex with STAT1 (show STAT1 Antibodies)-alpha within the nucleus and regulating IFN-gamma (show IFNG Antibodies)-mediated STAT1 (show STAT1 Antibodies)-alpha activation.

8. Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.

9. silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation

10. TRADD is a multifunctional protein crucial both for TNFR1 (show TNFRSF1A Antibodies) signaling and other signaling pathways relevant to immune responses.

Cow (Bovine) TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

1. TNF (show TNF Antibodies) binding induces release of AIP1 (DAB2IP (show DAB2IP Antibodies)) from TNFR1 (show TNFRSF1A Antibodies), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (show RALBP1 Antibodies), TRAF2 (show TRAF2 Antibodies), and AIPl.