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Human Polyclonal TRADD Primary Antibody for IF (p), IHC (p) - ABIN673314
Chen, Zhang, Zhang, Li, Sun: Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling. in Biochemical and biophysical research communications 2016
Human Polyclonal TRADD Primary Antibody for IHC (p), IHC - ABIN407974
Chakraborty, Li, Tang, Xie, Puliyappadamba, Raisanen, Burma, Boothman, Cochran, Wu, Habib: Cytoplasmic TRADD confers a worse prognosis in glioblastoma. in Neoplasia (New York, N.Y.) 2013
Human Polyclonal TRADD Primary Antibody for IP, IHC - ABIN223257
Chen, Texada, Duggan, Liang, Reden, Kooragayala, Langford: Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. in The Journal of biological chemistry 2005
Human Monoclonal TRADD Primary Antibody for FACS, WB - ABIN4899051
Kolliputi, Waxman: IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. in American journal of respiratory cell and molecular biology 2009
potential biological significance of TRADD mediated inflammatory response in the development of uterine leiomyoma, is reported.
we found that ORF3 (show ASZ1 Antibodies) protein downregulates TLR3 (show TLR3 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) signaling via TRADD and RIP1 (show UQCRFS1 Antibodies). Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.
In conclusion, for the first time, we report that TRADD, TRAF2 (show TRAF2 Antibodies), RIP1 (show UQCRFS1 Antibodies) and TAK1 (show MAP3K7 Antibodies) play a role in the regulating TNF-alpha (show TNF Antibodies) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (show TNF Antibodies) in the processes of human labour and delivery.
These data for the first time identifies miR (show MLXIP Antibodies)-485-5p/TRADD axis in hydrogen sulfide (show SQRDL Antibodies) protecting against TNF-alpha (show TNF Antibodies)-induced neuronal cell apoptosis.
By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling.
NPM (show NPM1 Antibodies)-RAR (show RARA Antibodies) binding to TRADD selectively inhibits caspase (show CASP3 Antibodies) activation, while allowing activation of NFkappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies)
The release of extracellular vesicles was triggered by TNFA (show TNF Antibodies) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (show TNFRSF1A Antibodies) and TRADD.
MicroRNA-30c-2-3p negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (show CCNE1 Antibodies) in breast cancer.
domains of calmodulin mediate FADD (show FADD Antibodies) and TRADD interaction
PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (show TNFRSF1A Antibodies)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (show TNFRSF1A Antibodies)/RIP (show HRB Antibodies)/NF-kappaB (show NFKB1 Antibodies) 50/NF-kappaB (show NFKB1 Antibodies) 65).
TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 Antibodies)/p38 MAPK (show MAPK14 Antibodies) but not AKT (show AKT1 Antibodies) phosphorylation
Data indicate that ASK1 (show MAP3K5 Antibodies) activation stimulated the activity of the transcription factor FoxO3a (show FOXO3 Antibodies), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (show CASP8 Antibodies).
data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (show NFKB1 Antibodies) activation.
TRADD is required for recruitment of receptor interacting protein 1 (show RIPK1 Antibodies) and TNFR (show TNFRSF1A Antibodies)-associated factor 2 to the DR3 (show TNFRSF25 Antibodies) signaling complex and for the ubiquitination of receptor interacting protein 1 (show RIPK1 Antibodies)
We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (show RALBP1 Antibodies) recruitment is mediated by TRADD.
TRADD may be involved in IFN-gamma (show IFNG Antibodies) signaling by forming a complex with STAT1 (show STAT1 Antibodies)-alpha within the nucleus and regulating IFN-gamma (show IFNG Antibodies)-mediated STAT1 (show STAT1 Antibodies)-alpha activation.
Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation
TRADD is a multifunctional protein crucial both for TNFR1 (show TNFRSF1A Antibodies) signaling and other signaling pathways relevant to immune responses.
TNF (show TNF Antibodies) binding induces release of AIP1 (DAB2IP (show DAB2IP Antibodies)) from TNFR1 (show TNFRSF1A Antibodies), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (show RALBP1 Antibodies), TRAF2 (show TRAF2 Antibodies), and AIPl.
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
TNFRSF1A-associated via death domain
, conjugal transfer protein D
, TNFR1-associated death domain protein
, tumor necrosis factor receptor type 1 associated death domain protein
, tumor necrosis factor receptor type 1-associated DEATH domain protein
, tumor necrosis factor receptor-1-associated protein
, TNF receptor 1 associated signal transducer
, TNFR1-associated DEATH domain protein
, Tumor necrosis factor receptor type 1-associated DEATH domain protein
, TNFRSF1A-associated via death domain protein