Browse our anti-TRAF1 (TRAF1) Antibodies

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 1 (TRAF1) interaction partners

1. Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.

2. Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.

3. Expression of Reaper leads to a loss of DIAP1 (show DIAPH1 Antibodies) inhibition of DTRAF1-mediated JNK (show MAPK8 Antibodies) activation in Drosophila cells.

4. DTRAF1-null mutant showed a remarkable reduction in JNK (show MAPK8 Antibodies) activity with an impaired development of imaginal discs and a defective formation of photosensory neuron arrays.

Human TNF Receptor-Associated Factor 1 (TRAF1) interaction partners

1. Authors demonstrated that TRAF1 expression had no significant prognostic value for GBM.

2. TRAF1 functions as a positive regulator of insulin (show INS Antibodies) resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1 (show MAP3K5 Antibodies)-P38 (show CRK Antibodies)/JNK (show MAPK8 Antibodies) axis.

3. The structure reveals both similarities and differences with other TRAF family members, which may be functionally relevant to TRAFs. The authors also found that the TRAF-N coiled-coil domain of TRAF1 is critical for the trimer formation and stability of the protein.

4. this study reveals an unexpected role for TRAF1 in negatively regulating Toll-like receptor signaling, providing a mechanistic explanation for the increased inflammation seen with a rheumatoid arthritis-associated single-nucleotide polymorphism in the TRAF1 gene

5. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA (show S100A8 Antibodies)-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells.

6. Alleles of rs2416804 in TRAF1 were identified as being linked and associated with carotid intima-media thickness.

7. Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex has been reported.

8. Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (show AGTR1 Antibodies)), transcription factor AP-2 beta (TFAP2B (show TFAP2B Antibodies)), and tumor necrosis factor (show TNF Antibodies) receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants.

9. TRAF1 plays a crucial role in the pathogenesis of autoantibodies and may serve as a serologic inflammatory marker of disease activity in rheumatoid arthritis patients.

10. Helicobacter pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. The upregulation of TRAF1 plays an antiapoptotic role in Helicobacte pylori -infected gastric cells and may contribute to the gastric carcinogenesis.

Mouse (Murine) TNF Receptor-Associated Factor 1 (TRAF1) interaction partners

1. this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock

2. NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Antibodies)), cellular inhibitor of apoptosis (cIAP2 (show BIRC3 Antibodies)), and Ferritin heavy chain (FTH1 (show FTH1 Antibodies)) were increased following Losartan treatment

3. TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.

4. Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions.

5. The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways.

6. Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB (show TNFRSF9 Antibodies) in primary T cells.

7. TRAF1 and LSP1 (show LSP1 Antibodies) cooperate downstream of 4-1BB (show TNFRSF9 Antibodies) to activate ERK (show EPHB2 Antibodies) signaling and down-modulate the levels of Bim (show BCL2L11 Antibodies) leading to enhanced T cell survival.

8. TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK (show MAP4K4 Antibodies) in activated T cells and by promoting the 4-1BB (show TNFRSF9 Antibodies)-induced classical NF-kappaB (show NFKB1 Antibodies) pathway.

9. These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 (show CD8A Antibodies) T cell fitness during the chronic phase of disease and a target for therapy.

10. combined signaling from the TNF (show TNF Antibodies) or IL-1 (show IL1A Antibodies) receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection