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anti-Human TRAF6 Antibodies:
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Human Polyclonal TRAF6 Primary Antibody for WB - ABIN1881900
Hinz, Stilmann, Arslan, Khanna, Dittmar, Scheidereit: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. in Molecular cell 2010
Show all 4 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, ELISA - ABIN1003297
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC (fro), IHC (p) - ABIN537432
Ichii, Otsuka, Sasaki, Namiki, Hashimoto, Kon: Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. in Kidney international 2012
Show all 3 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for WB - ABIN3043950
Yuan, Zhang, Yang: Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats. in Evidence-based complementary and alternative medicine : eCAM 2014
Show all 2 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, IHC (fro) - ABIN3044469
Liu, Wang, Qian, Li: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. in International journal of molecular medicine 2014
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Human Polyclonal TRAF6 Primary Antibody for FACS, WB - ABIN4361690
Yoshida, Jono, Kai, Li: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. in The Journal of biological chemistry 2005
Show all 2 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ELISA, ICC - ABIN6265707
Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway. in Evidence-based complementary and alternative medicine : eCAM 2018
Human Polyclonal TRAF6 Primary Antibody for IF (p), IHC (p) - ABIN738906
Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. in Scientific reports 2017
Human Polyclonal TRAF6 Primary Antibody for IF (p) - ABIN918441
Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. in Journal of experimental & clinical cancer research : CR 2017
Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC, IHC (p) - ABIN4361692
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Study identified IRAK1 (show IRAK1 Antibodies) and TRAF6 are direct targets of miR (show MLXIP Antibodies)-146a in cervical cancer cells. Their expression is downregulated by miR (show MLXIP Antibodies)-146a to promote cell viability.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (show CRK Antibodies)/TRAF-6/ERK (show EPHB2 Antibodies) MAP kinases pathways has been reported.
Downregulation of miR (show MLXIP Antibodies)-124 in human osteosarcoma tissues and cell lines may increase the expression of TRAF6 protein. miR (show MLXIP Antibodies)-124 may inhibit cell cycle progression and invasion of osteosarcoma cells, and promote apoptosis by regulating TRAF6.
Low TRAF6 expression is associated with posterior longitudinal ligament ossification.
these results suggest that miR (show MLXIP Antibodies)-146a-5p affects proliferation and apoptosis in a cellular context-dependent manner and selectively disarms the TRAF6-mediated branch of the TGF-beta (show TGFB1 Antibodies) signaling in oral squamous cell carcinoma cell lines by sparing Smad4 (show SMAD4 Antibodies) involvement
MALT1 (show MALT1 Antibodies) and TRAF6 cooperatively interact with CARMA1 (show CARD11 Antibodies)-BCL10 (show BCL10 Antibodies) filaments and form CARMA1 (show CARD11 Antibodies)-BCL10 (show BCL10 Antibodies)-MALT1 (show MALT1 Antibodies)-TRAF6 signalosome.
our data demonstrated that miR146b5p, as a tumor suppressor, mediated temozolomide resistance in GBM cells through negatively regulating TRAF6 expression, indicating that miR146b5p and its targeted genes would be potential therapeutic targets for glioma therapy.
genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (show NLRX1 Antibodies) (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (show NLRX1 Antibodies) (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (NLRX1 (show NLRX1 Antibodies) = NLR family member-X1 (show NLRX1 Antibodies))
protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.
miR (show MLXIP Antibodies)-146a suppresses the inflammatory response in human white adipocytes via targeting the expression of IRAK1 (show IRAK1 Antibodies) and TRAF6.
Results demonstrate that TRAF6 interacts with MyD88 (show MYD88 Antibodies) and suggest that TRAF6 participates in protection from basal autophagy.
Klf4 (show KLF4 Antibodies) Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 (show CPT1B Antibodies) Induced Protein 1 to Deubiquitinate TRAF6.
TRAF6 RING dimer employs a concerted allosteric mechanism using both subunits of the TRAF6 dimer to promote ubiquitin (Ub) transfer.
miR (show MLXIP Antibodies)-146a-mediated control of Traf6 expression Is required for the attenuation of proinflammatory cytokine responses, control of T cell tolerance, and prevention of autoimmunity.
Data indicate TNF receptor associated factor 6 (TRAF6) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1 (show MAP3K7 Antibodies)), -dependent manner.
Berberine hydrochloride targets TRAF6 and NFATc1 (show NFATC1 Antibodies).
The authors found that keratin 8 (show KRT8 Antibodies) suppressed toll (show TLR4 Antibodies)-like receptor-induced nuclear factor (NF)-kappaB (show NFKB1 Antibodies) activation and interacted with the adaptor tumor necrosis factor (TNF (show TNF Antibodies)) receptor-associated factor 6 (TRAF6) to prevent its polyubiquitination.
MiR (show MLXIP Antibodies)-146a/ MiR (show MLXIP Antibodies)-146b could down-regulate the TRAF6 and IRAK1 (show IRAK1 Antibodies) expression and promote proliferation, migration and angiogenesis ability of endothelial progenitor cells, which could be important for recovery of patients with hyperacute ischemic stroke.
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Antibodies) activity by dissociating Atg9 (show ATG9A Antibodies)/mAtg9 (show ATG9A Antibodies) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
E3 ubiquitin-protein ligase TRAF6
, RING finger protein 85
, TNF receptor-associated factor 6
, interleukin-1 signal transducer
, TNF receptor-associated factor 6-B
, TNF-receptor-associated factor 2
, TNF-receptor associated factor 6
, TNF receptor-associated factor 6-like
, TNF receptor-associated factor 6-A
, TNF receptor-associated factor 6, E3 ubiquitin protein ligase