Browse our anti-TRAF6 (TRAF6) Antibodies

Human TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

1. TRAF6 plays a vital role in the progression of colorectal cancer.

2. The results provide direct evidence and a structural basis for the TIFA-TRAF6 interaction, and show how this important biological function can be modulated.

3. Investigated the role of neddylation in collagen-induced arthritis (CIA); found TNF receptor-associated factor 6 (TRAF6) neddylation at Lys124 was essential for IL-17A-induced NF-kappaB activation in inflammatory arthritis.

4. these findings suggest that GADD34 inhibits TRAIL-induced HCC cell apoptosis through TRAF6- and ERK-mediated stabilization of MCL-1.

5. PRDX1 negatively regulates TLR4 signaling for NFKB activation and autophagy functions such as bactericidal activity, cancer cell migration, and cancer cell invasion by inhibiting TRAF6 ubiquitin-ligase activity.

6. Beclin-1 underwent K63-polyubiquitination upon RIG-I activation, and the ubiquitination decreased in TRAF6-deficient cells. This suggests that the RIG-I-MAVS-TRAF6 axis induced K63-linked polyubiquitination of Beclin-1, which has been implicated in triggering autophagy.

7. High expression of smoothened receptor (SMO) and TNF receptor associated factor 6 (TRAF6) correlates with poor prognosis in patients with diffuse large B cell lymphoma (DLBCL).

8. These results reveal that TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer.

9. This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low bone mineral density among patients with rheumatoid arthritis.

10. Downregulation of miR146a in human cervical cancer cells induced TRAF6 and NFkappaB protein expression. The inhibition of TRAF6 attenuated the effects of antimiR146a on the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. Collectively, miR146a regulated the function of Th17 cell differentiation through NFkappaB signaling by targeting TRAF6.

11. Tumor necrosis factor receptor-associated factor 6 (TRAF6)-mediated proto-oncogene protein Akt (AKT) ubiquitination and subsequent phosphorylation played an essential role in the control of tumor cell malignant behavior.

12. the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.

13. we show that knockdown of TRAF6 sensitizes MM cells to treatment with bortezomib when co-cultured with stromal cells. Inhibiting TRAF6 represents a promising strategy to target MM cells in the BM microenvironment.

14. miR323 suppresses nerve cell apoptosis in cerebral infarction via the TGFbeta1/SMAD3 signaling pathway.

15. MALT1 activation by TRAF6 in lymphocytes needs neither BCL10 nor CARD11.

16. TARBP2 participates in the interaction between IRF7 and TRAF6, thereby suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.

17. TRAF6 plays a role in Epithelial-mesenchymal transition phenotypes, the generation and maintenance of cancer stem cells in squamous cell carcinoma of head and neck.

18. TIFAB gene may act as a Coronary Artery Aneurysm susceptibility locus in patients with Kawasaki Disease.

19. TRAF6 is a novel PIK3CA regulator whose deregulated overexpression represents a mechanism for PI3K overactivation in tumors.

20. TRAF6 was identified as an independent prognostic factor of glioblastoma multiforme, with ability to promote tumor invasiveness via elevating expression of MMP9.

Mouse (Murine) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

1. miR-590-3p has the ability to suppress LPS-induced Acute Kidney Injury and podocyte apoptosis by targeting TRAF6

2. our data suggest that NUMBL and TAK1 are reciprocally regulated and that NUMBL acts as an endogenous regulator of NF-kappaB signaling and osteoclastogenesis by targeting the TAK1-TRAF6-NEMO axis.

3. TRAF6 is required for hematopoietic stem cell homeostasis by maintaining a minimal threshold level of IKKbeta/NF-kappaB signaling.

4. Conditional deletion of TRAF6 in the intestinal epithelium causes a complete loss of M cells in Peyer patches (PPs), resulting in impaired antigen uptake into PPs.

5. the expression of TRAF6 in T cells might be implicated in tissue-specific sialadenitis by regulating the chemokine-chemokine receptor system

6. The data suggest that TFAF6 inhibition reduces choroidal neovascularization formation via down-regulating expression of HIF-1a and VEGF and activation of macrophages and microglia.

7. Traf6 plays a crucial role in regulating M1 osteoclast and M2 foreign body giant cell polarization.

8. Authors report that the deletion of TRAF6 in hematopoietic lineage cells resulted in the upregulation of HSPCs in the fetal liver at the prenatal period. However, in the early postnatal period, deletion of TRAF6 drastically diminished HSPCs in the bone marrow (BM), with severe defects in BM development and extramedullary hematopoiesis in the spleen being identified.

9. Study demonstrated that TRAF6 plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2, and further increasing ubiquitination of TRAF6.

10. atorvastatin treatment may protect BV2 microglia and hippocampal neurons from oxygenglucose deprivationinduced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NFkappaB pathway. This may provide a potential strategy for the treatment of neuronal injury.

11. these findings identify IPMK as a key determinant of TRAF6 stability and elucidate the physiological function of IPMK in TLR-induced innate immunity.

12. Results demonstrate that TRAF6 interacts with MyD88 and suggest that TRAF6 participates in protection from basal autophagy.

13. Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.

14. TRAF6 RING dimer employs a concerted allosteric mechanism using both subunits of the TRAF6 dimer to promote ubiquitin (Ub) transfer.

15. Low TRAF6 expression is associated with posterior longitudinal ligament ossification.

16. miR-146a-mediated control of Traf6 expression Is required for the attenuation of proinflammatory cytokine responses, control of T cell tolerance, and prevention of autoimmunity.

17. Data indicate TNF receptor associated factor 6 (TRAF6) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1), -dependent manner.

18. Berberine hydrochloride targets TRAF6 and NFATc1.

19. protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.

20. The authors found that keratin 8 suppressed toll-like receptor-induced nuclear factor (NF)-kappaB activation and interacted with the adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) to prevent its polyubiquitination.

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

1. oalescence-mediated enzymatic activity of Otu is positively regulated by its bound RNAs and co-partner Bam. Further genetic analysis reveals that the Otu/Bam deubiquitinase complex and dTraf6 constitute a feedback loop to maintain intestinal immune homeostasis during aging, thereby controlling longevity.

2. we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila.

3. null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired

Pig (Porcine) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

1. Silencing Mettl3 could sustain long-chain fatty acids absorption through blocking the TRAF6-dependent inflammation response.

2. TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication via activation of NF-kappaB-signaling pathways.

Zebrafish TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

1. we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity

2. Full-length traf6 was functionally characterized.