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anti-Mouse (Murine) TRAF6 Antibodies:
anti-Human TRAF6 Antibodies:
anti-Rat (Rattus) TRAF6 Antibodies:
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Human Polyclonal TRAF6 Primary Antibody for WB - ABIN1881900
Hinz, Stilmann, Arslan, Khanna, Dittmar, Scheidereit: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. in Molecular cell 2010
Show all 4 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, ELISA - ABIN1003297
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC (fro), IHC (p) - ABIN537432
Ichii, Otsuka, Sasaki, Namiki, Hashimoto, Kon: Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. in Kidney international 2012
Show all 3 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for FACS, WB - ABIN4361690
Yoshida, Jono, Kai, Li: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. in The Journal of biological chemistry 2005
Show all 2 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, IHC (fro) - ABIN3044469
Yuan, Zhang, Yang: Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats. in Evidence-based complementary and alternative medicine : eCAM 2014
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Human Polyclonal TRAF6 Primary Antibody for IF (p) - ABIN918441
Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. in Journal of experimental & clinical cancer research : CR 2017
Human Polyclonal TRAF6 Primary Antibody for IF (p), IHC (p) - ABIN738906
Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. in Scientific reports 2017
Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC, IHC (p) - ABIN4361692
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Human Polyclonal TRAF6 Primary Antibody for ELISA, ICC - ABIN4361694
Doyon, Servant et al.: Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase ... in The Journal of biological chemistry 2010
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Antibodies) activity by dissociating Atg9 (show ATG9A Antibodies)/mAtg9 (show ATG9A Antibodies) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (show UBE2N Antibodies)/Ub~Ubc13 (show UBE2N Antibodies) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 (show WDFY3 Antibodies) and the RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (show NLRP3 Antibodies) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (show TP53 Antibodies) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (show TP53 Antibodies) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 (show MYO15 Antibodies) domain of STAT3 (show STAT3 Antibodies), which is an essential step for STAT3 (show STAT3 Antibodies) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (show CUL5 Antibodies) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (show TNFSF11 Antibodies) enhances TNF (show TNF Antibodies)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (show TRAF3 Antibodies), a known inhibitor of osteoclastogenesis. (RANKL (show TNFSF11 Antibodies) = osteoclast differentiation factor (show TNFSF11 Antibodies); TNF (show TNF Antibodies) = tumor necrosis factor (show TNF Antibodies); Traf (show TRAF1 Antibodies) = TNF (show TNF Antibodies) receptor-associated factor)
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
miRNA146a expression was significantly higher in hepatitis C patients with a best cut off value 1.63 to discriminate between hepatitis C patients and healthy controls. Meanwhile, it was negatively correlated to IRAK1 (show IRAK1 Antibodies) and TRAF6 levels and positively correlated to viral load in hepatitis C patients.
Suggest role for EBV-EBER1 in the induction of increased TRAF6 expression in the peripheral B cells of Sjogren's patients.
theses results indicate that miR (show MLXIP Antibodies)-146b-5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting TRAF6 mediated Akt (show AKT1 Antibodies) phosphorylation
TRAF6 plays direct roles in the pro-inflammatory effects and proliferation of Rheumatoid arthritis (RA) fibroblast-like synoviocytes. TRAF6 may serve as a potential treatment target in RA.
MiR (show MLXIP Antibodies)-146a declined, while TRAF6 increased in lupus nephritis patients compared with healthy controls.
Epigallocatechin-3-gallate is a novel E3 ubiquitin ligase (show MUL1 Antibodies) inhibitor that could be used to target TRAF6 activity in melanoma cells, inhibiting cell proliferation/migration.
Results identified TRAF6 as a direct target of miR (show MLXIP Antibodies)-429, and its downregulation partially attenuates the effect of miR (show MLXIP Antibodies)-429 in promoting hepatocellular carcinoma cell proliferation and motility.
Compared with normal chondrocytes, the expression of miR (show MLXIP Antibodies)-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-kappaB (show NFKB1 Antibodies) increased in osteoarthritis chondrocytes.
We report two siblings with SCID (show PRKDC Antibodies) and an atypical phenotype of osteopetrosis (OP (show CSF1 Antibodies)). A biallelic microdeletion encompassing the 5' region of TRAF6, RAG1 (show RAG1 Antibodies) and RAG2 (show RAG2 Antibodies) genes was identified. TRAF6, a tumor necrosis factor (show TNF Antibodies) receptor-associated family member, plays an important role in T cell signaling and in RANKL (show TNFSF11 Antibodies)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported
miR (show MLXIP Antibodies)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4 (show TLR4 Antibodies), TRAF6, and p-IkappaBalpha (show NFKBIA Antibodies), subsequently leading to decreased NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) nuclear translocation.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6