-
TRAF6 plays a vital role in the progression of colorectal cancer.
-
The results provide direct evidence and a structural basis for the TIFA-TRAF6 interaction, and show how this important biological function can be modulated.
-
Investigated the role of neddylation in collagen-induced arthritis (CIA); found TNF receptor-associated factor 6 (TRAF6) neddylation at Lys124 was essential for IL-17A-induced NF-kappaB activation in inflammatory arthritis.
-
these findings suggest that GADD34 inhibits TRAIL-induced HCC cell apoptosis through TRAF6- and ERK-mediated stabilization of MCL-1.
-
PRDX1 negatively regulates TLR4 signaling for NFKB activation and autophagy functions such as bactericidal activity, cancer cell migration, and cancer cell invasion by inhibiting TRAF6 ubiquitin-ligase activity.
-
Beclin-1 underwent K63-polyubiquitination upon RIG-I activation, and the ubiquitination decreased in TRAF6-deficient cells. This suggests that the RIG-I-MAVS-TRAF6 axis induced K63-linked polyubiquitination of Beclin-1, which has been implicated in triggering autophagy.
-
High expression of smoothened receptor (SMO) and TNF receptor associated factor 6 (TRAF6) correlates with poor prognosis in patients with diffuse large B cell lymphoma (DLBCL).
-
These results reveal that TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer.
-
This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low bone mineral density among patients with rheumatoid arthritis.
-
Downregulation of miR146a in human cervical cancer cells induced TRAF6 and NFkappaB protein expression. The inhibition of TRAF6 attenuated the effects of antimiR146a on the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. Collectively, miR146a regulated the function of Th17 cell differentiation through NFkappaB signaling by targeting TRAF6.
-
Tumor necrosis factor receptor-associated factor 6 (TRAF6)-mediated proto-oncogene protein Akt (AKT) ubiquitination and subsequent phosphorylation played an essential role in the control of tumor cell malignant behavior.
-
the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.
-
we show that knockdown of TRAF6 sensitizes MM cells to treatment with bortezomib when co-cultured with stromal cells. Inhibiting TRAF6 represents a promising strategy to target MM cells in the BM microenvironment.
-
miR323 suppresses nerve cell apoptosis in cerebral infarction via the TGFbeta1/SMAD3 signaling pathway.
-
MALT1 activation by TRAF6 in lymphocytes needs neither BCL10 nor CARD11.
-
TARBP2 participates in the interaction between IRF7 and TRAF6, thereby suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.
-
TRAF6 plays a role in Epithelial-mesenchymal transition phenotypes, the generation and maintenance of cancer stem cells in squamous cell carcinoma of head and neck.
-
TIFAB gene may act as a Coronary Artery Aneurysm susceptibility locus in patients with Kawasaki Disease.
-
TRAF6 is a novel PIK3CA regulator whose deregulated overexpression represents a mechanism for PI3K overactivation in tumors.
-
TRAF6 was identified as an independent prognostic factor of glioblastoma multiforme, with ability to promote tumor invasiveness via elevating expression of MMP9.