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Human TRAF6 Protein expressed in Wheat germ - ABIN1323514
Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010
Human TRAF6 Protein expressed in HEK-293 Cells - ABIN2734115
Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015
Study identified IRAK1 (show IRAK1 Proteins) and TRAF6 are direct targets of miR (show MLXIP Proteins)-146a in cervical cancer cells. Their expression is downregulated by miR (show MLXIP Proteins)-146a to promote cell viability.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (show CRK Proteins)/TRAF-6/ERK (show EPHB2 Proteins) MAP kinases pathways has been reported.
Downregulation of miR (show MLXIP Proteins)-124 in human osteosarcoma tissues and cell lines may increase the expression of TRAF6 protein. miR (show MLXIP Proteins)-124 may inhibit cell cycle progression and invasion of osteosarcoma cells, and promote apoptosis by regulating TRAF6.
Low TRAF6 expression is associated with posterior longitudinal ligament ossification.
these results suggest that miR (show MLXIP Proteins)-146a-5p affects proliferation and apoptosis in a cellular context-dependent manner and selectively disarms the TRAF6-mediated branch of the TGF-beta (show TGFB1 Proteins) signaling in oral squamous cell carcinoma cell lines by sparing Smad4 (show SMAD4 Proteins) involvement
MALT1 (show MALT1 Proteins) and TRAF6 cooperatively interact with CARMA1 (show CARD11 Proteins)-BCL10 (show BCL10 Proteins) filaments and form CARMA1 (show CARD11 Proteins)-BCL10 (show BCL10 Proteins)-MALT1 (show MALT1 Proteins)-TRAF6 signalosome.
our data demonstrated that miR146b5p, as a tumor suppressor, mediated temozolomide resistance in GBM cells through negatively regulating TRAF6 expression, indicating that miR146b5p and its targeted genes would be potential therapeutic targets for glioma therapy.
genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (NLRX1 = NLR family member-X1)
protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.
miR (show MLXIP Proteins)-146a suppresses the inflammatory response in human white adipocytes via targeting the expression of IRAK1 (show IRAK1 Proteins) and TRAF6.
Study demonstrated that TRAF6 plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2 (show FBXL2 Proteins), and further increasing ubiquitination of TRAF6.
atorvastatin treatment may protect BV2 microglia and hippocampal neurons from oxygenglucose deprivationinduced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NFkappaB pathway. This may provide a potential strategy for the treatment of neuronal injury.
these findings identify IPMK (show IPMK Proteins) as a key determinant of TRAF6 stability and elucidate the physiological function of IPMK (show IPMK Proteins) in TLR-induced innate immunity.
Results demonstrate that TRAF6 interacts with MyD88 (show MYD88 Proteins) and suggest that TRAF6 participates in protection from basal autophagy.
Klf4 (show KLF4 Proteins) Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 (show CPT1B Proteins) Induced Protein 1 to Deubiquitinate TRAF6.
TRAF6 RING dimer employs a concerted allosteric mechanism using both subunits of the TRAF6 dimer to promote ubiquitin (Ub) transfer.
miR (show MLXIP Proteins)-146a-mediated control of Traf6 expression Is required for the attenuation of proinflammatory cytokine responses, control of T cell tolerance, and prevention of autoimmunity.
Data indicate TNF receptor associated factor 6 (TRAF6) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1 (show MAP3K7 Proteins)), -dependent manner.
Berberine hydrochloride targets TRAF6 and NFATc1 (show NFATC1 Proteins).
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Proteins) activity by dissociating Atg9 (show ATG9A Proteins)/mAtg9 (show ATG9A Proteins) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
E3 ubiquitin-protein ligase TRAF6
, RING finger protein 85
, TNF receptor-associated factor 6
, interleukin-1 signal transducer
, TNF receptor-associated factor 6-B
, TNF-receptor-associated factor 2
, TNF-receptor associated factor 6
, TNF receptor-associated factor 6-like
, TNF receptor-associated factor 6-A
, TNF receptor-associated factor 6, E3 ubiquitin protein ligase