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Human TRAF6 Protein expressed in Wheat germ - ABIN1323514
Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010
Human TRAF6 Protein expressed in HEK-293 Cells - ABIN2734115
Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Proteins) activity by dissociating Atg9 (show ATG9A Proteins)/mAtg9 (show ATG9A Proteins) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (show UBE2N Proteins)/Ub~Ubc13 (show UBE2N Proteins) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 and the RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (show NLRP3 Proteins) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (show TP53 Proteins) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (show TP53 Proteins) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (show STAT3 Proteins), which is an essential step for STAT3 (show STAT3 Proteins) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (show CUL5 Proteins) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (show TNFSF11 Proteins) enhances TNF (show TNF Proteins)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (show TRAF3 Proteins), a known inhibitor of osteoclastogenesis. (RANKL (show TNFSF11 Proteins) = osteoclast differentiation factor (show TNFSF11 Proteins); TNF (show TNF Proteins) = tumor necrosis factor (show TNF Proteins); Traf (show TRAF1 Proteins) = TNF (show TNF Proteins) receptor-associated factor)
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Results identified TRAF6 as a direct target of miR (show MLXIP Proteins)-429, and its downregulation partially attenuates the effect of miR (show MLXIP Proteins)-429 in promoting hepatocellular carcinoma cell proliferation and motility.
Compared with normal chondrocytes, the expression of miR (show MLXIP Proteins)-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-kappaB (show NFKB1 Proteins) increased in osteoarthritis chondrocytes.
We report two siblings with SCID (show PRKDC Proteins) and an atypical phenotype of osteopetrosis (OP (show CSF1 Proteins)). A biallelic microdeletion encompassing the 5' region of TRAF6, RAG1 (show RAG1 Proteins) and RAG2 (show RAG2 Proteins) genes was identified. TRAF6, a tumor necrosis factor (show TNF Proteins) receptor-associated family member, plays an important role in T cell signaling and in RANKL (show TNFSF11 Proteins)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported
miR (show MLXIP Proteins)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4 (show TLR4 Proteins), TRAF6, and p-IkappaBalpha (show NFKBIA Proteins), subsequently leading to decreased NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) nuclear translocation.
Taken together, these results define a novel role for miR (show MLXIP Proteins)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (show YOD1 Proteins) antagonizes TRAF6/p62 (show GTF2H1 Proteins)-dependent IL-1 (show IL1A Proteins) signaling to NF-kappaB (show NFKB1 Proteins).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (show CRBN Proteins) negatively regulates TLR4 (show TLR4 Proteins) signaling via attenuation of TRAF6 and TAB2 (show TAB2 Proteins) ubiquitination.
the polymorphisms in TLR-MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6