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Notch is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing
Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation.
The results indicate that DTX4 stable knockdown inhibits adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha and PPARgamma, arresting mitotic clonal expansion and regulating Wnt signaling pathway.
Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
deltex 4 homolog
, E3 ubiquitin-protein ligase DTX4
, RING finger protein 155
, protein deltex-4
, deltex 4, E3 ubiquitin ligase
, deltex homolog 4
, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase DTX4