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Macrophage maturation is controlled by Notch ligand (show JAG2 Proteins) Dll1 expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch (show NOTCH1 Proteins) signaling via Rbpj (show RBPJ Proteins), which simultaneously suppresses an inflammatory macrophage fate. Conversely, conditional mutant mice lacking Dll1 or Rbpj (show RBPJ Proteins) show proliferation and transient accumulation of inflammatory macrophages, which antagonizes arteriogenesis and tissue repair.
pre-coated Notch1 (show NOTCH1 Proteins) protein promotes Notch1 (show NOTCH1 Proteins)-knocked down B cells to produce antibody in LPS (show TLR4 Proteins)-stimulated B cells suggesting that Notch1 (show NOTCH1 Proteins) in other cells may promote antibody production by binding its ligands Dll1 and Jag1 (show JAG1 Proteins) in B cells.
Hedgehog (show SHH Proteins)/Patched (show PTCH1 Proteins)-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
the effects of two Notch (show NOTCH1 Proteins) ligands, i.e., Jagged1 (show JAG1 Proteins) and DLL1, on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 Proteins) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
the structural integrity of each individual EGF (show EGF Proteins) repeat in the extracellular domain of DLL1 is necessary for full DLL1 activity
A novel mouse xenograft model to study the role of TSLP (show TSLP Proteins)-induced CRLF2 (show CRLF3 Proteins) signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR (show CRLF2 Proteins) expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR (show CRLF2 Proteins), potentially through the PI3K/Akt (show AKT1 Proteins) signal pathway.
Role of Dll1 in embryogenesis and notch (show NOTCH1 Proteins) signaling.
the appropriate timing of Dll1 expression is critical for the oscillatory networks and suggest the functional significance of oscillatory cell-cell interactions in tissue morphogenesis
Highly methylated domains containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in autism spectrum disorders children than in controls.
The DLK1 (show DLK1 Proteins) inhibited the odontoblastic differentiation of hDPSCs, which maybe through ERK (show EPHB2 Proteins) signalling pathway.
DLL1-mediated Notch (show NOTCH1 Proteins) signaling is critical for proper bone remodeling as it regulates the differentiation and function of both osteoblasts and osteoclasts.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
Gain-of-function and loss-of-function studies demonstrated that miR (show MLXIP Proteins)-130b-3p could inhibit breast carcinoma cell invasion and migration by directly targeting the Notch ligand (show JAG2 Proteins) Delta-like 1 (DLL1).
Mir (show MLXIP Proteins)-34a functions as a regulator by decreasing the expression of NOTCH1 (show NOTCH1 Proteins) and DLL1. Our study is the first to identify a correlation between mir (show MLXIP Proteins)-34a and its target genes NOTCH1 (show NOTCH1 Proteins) and DLL1 in endometrial adenocarcinoma
High DLL1 levels were associate with reduced exercise capacity and diastolic dysfunction in chronic heart failure patients.
Although Delta1 activates signal transducer and activator of transcription 3 (show STAT3 Proteins) signaling similarly to the gp130 (show IL6ST Proteins)-activating cytokine interleukin-6 (IL-6 (show IL6 Proteins)), it has opposite effects on myeloid cell production.
Notch ligand (show JAG2 Proteins) Dll1 may enhance the adhesion and metastasis of melanoma cells by upregulation of N-cadherin (show CDH2 Proteins).
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
delta-like 1 (Drosophila)
, TSLP receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal lymphopoietin protein receptor
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1
, delta-like protein 1
, drosophila Delta homolog 1
, delta like-1
, delta-like 1