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we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR (show MLXIP Proteins)-25 in esophageal squamous cell carcinoma (ESCC). In conclusion, the present study supports the potential of miR (show MLXIP Proteins)-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC
FBXW7 was significantly downregulated in renal cell carcinoma (show MOK Proteins) cell lines. Upregulation of FBXW7 in 786-O and ACHN (show LARP6 Proteins) cell lines significantly inhibited cell migration, invasion and EMT (show ITK Proteins).
FBXW7 missense mutation is associated with metastatic colorectal adenocarcinoma.
miR (show MLXIP Proteins)-92b-3p inhibition prevented colorectal cancer proliferation, invasion, and migration by upregulating FBXW7, which might suggest the potential role of miR (show MLXIP Proteins)-92b-3p in colorectal carcinogenesis and metastasis.
FBXW7 is markedly downregulated in the liver of obese subjects. A functional low-frequency human FBXW7 coding variant ( (show AHSG Proteins)p.Ala204Thr) is associated with elevated blood glucose and T2DM risk in a Chinese population. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
Our findings suggest FBW7 mutational status and Mcl-1 (show MCL1 Proteins) stability as key determinants of response to Hsp90 (show HSP90 Proteins) inhibitors, which provides a rationale for using FBW7 genotype for potential patient stratification, and for drug combinations with Hsp90 (show HSP90 Proteins) inhibitors that can effectively overcome Mcl-1 (show MCL1 Proteins)-mediated resistance.
a cancer stem cell-specific FBXW7-regulatory mechanism is strongly associated with resistance to chemotherapeutic agents.
FBW7 promoted gemcitabine sensitivity via upregulation of equilibrative nucleoside transporter 1 (ENT1 (show SLC29A1 Proteins)) at the protein level rather than the transcriptional level.
FBW7 overexpression downregulated Aurora B (show AURKB Proteins), Mcl1 (show MCL1 Proteins) and Notch1 (show NOTCH1 Proteins) levels.
FBXW7 was a downstream target of miR (show MLXIP Proteins)-367 and CASC2 prohibited epithelial-to-mesenchymal transition progression and subsequently exerted its anti-metastatic effects via CASC2/miR (show MLXIP Proteins)-367/FBXW7 axis in hepatocellular carcinoma cells.
FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A (show AHSG Proteins) to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
the regulatory crosstalk between KLF5 (show KLF5 Proteins), miR (show MLXIP Proteins)-29a, and Fbw7/CDC4 cooperatively promotes atherosclerotic development
found that Fbw7 loss caused activation of NF-kappaB (show NFKB1 Proteins) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (show NFKB1 Proteins) pathway.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (show HLCS Proteins)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (show NOTCH2 Proteins) pathway as observed in patients with HCS (show HLCS Proteins).
The findings reveal a PLK1-Fbw7-Myc (show MYC Proteins) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Proteins) antagonists, as potential effective therapeutics for MYC (show MYC Proteins)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Proteins)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Proteins) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha (show NR1D1 Proteins) is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Proteins) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7-mediated REV-ERBalpha (show NR1D1 Proteins) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Proteins) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Proteins) infection induced the expression of FBXW7 in brain.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30