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FBW7 serves as a negative regulator of glucose metabolism through regulation of the c-Myc (show MYC Proteins)/TXNIP (show TXNIP Proteins) axis in pancreatic cancer.
increased expression of activated NOTCH1 (show NOTCH1 Proteins) was found in NOTCH1 (show NOTCH1 Proteins)/FBXW7 hotspot exon-mutated cases. Study suggests that NOTCH1 (show NOTCH1 Proteins)/FBXW7 hotspot-mutated T-ALL cases had better response to ALL BFM-95 protocol.
Study identify SCF (show KITLG Proteins)-FBW7 as a ubiquitin E3 ligase that regulates the cellular FAAP20 levels and Fanconi anemia (show PALB2 Proteins) (FA) pathway. Deregulation of the GSK3beta- and FBW7-dependent FAAP20 degradation leads to a defect in the FA pathway, establishing a direct link between FBW7 and DNA repair.
HRAS (show HRAS Proteins) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (show PLAG1 Proteins) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (show PLAG1 Proteins) and HMGA2 correlates with the presence of TP53 (show TP53 Proteins), FBXW7 mutations, or SMARCB1 (show SMARCB1 Proteins) deletion.
Data indicate the SCF (show KITLG Proteins)(Fbxw7)-independent regulatory mechanism centred on the highly conserved lysine-52 (K52) within MYC (show MYC Proteins) Box I.
Results identified FBXW7 as a functional target of miR (show MLXIP Proteins)-155-3p and demonstrated an involvement of FBXW7 in the effects of increased miR (show MLXIP Proteins)-155-3p on promoting clone formation and proliferation of hepatocellular carcinoma.
FBXW7alpha inhibits breast cancer cells survival by promoting GATA3 (show GATA3 Proteins) degradation/destabilizing GATA3 (show GATA3 Proteins).
Loss of FBW7 expression is associated with breast cancer.
FBXW7 could be a potential biomarker for predicting not only the clinical response to chemoradiotherapy but also overall survival in patients with oral squamous cell carcinoma
Our results reveal a new mechanism of ZNF322A (show ZNF322A Proteins) oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A (show ZNF322A Proteins) overexpression and promotes cancer progression
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (show HLCS Proteins)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (show NOTCH2 Proteins) pathway as observed in patients with HCS (show HLCS Proteins).
The findings reveal a PLK1-Fbw7-Myc (show MYC Proteins) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Proteins) antagonists, as potential effective therapeutics for MYC (show MYC Proteins)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Proteins)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Proteins) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha (show NR1D1 Proteins) is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Proteins) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7-mediated REV-ERBalpha (show NR1D1 Proteins) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Proteins) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Proteins) infection induced the expression of FBXW7 in brain.
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.
data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Proteins), modulate intestinal homeostasis and cancer.
These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30