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Vascular smooth muscle cells were cyclically stretched on flexible membranes, as quantified via video tracking, demonstrating that the expression of Jagged1, Notch3 (show NOTCH3 Proteins), and target genes was down-regulated with strain.
This study identifies the unique role of JAG1-induced Notch (show NOTCH1 Proteins) activation in the pathogenesis of multiple myeloma
is an autosomal dominant disorder found to be linked to the Notch ligand (show JAG2 Proteins) JAG1.5 Approximately 90 percent of patients presenting with Alagille Syndrome have a mutation on the JAG1 gene that is located on chromosome 20p12.
These data indicate a process of NF-kappaB (show NFKB1 Proteins)-induced miR (show MLXIP Proteins)-506 suppression and JAG1 upregulation upon IL-1beta (show IL1B Proteins) induction.
The Jagged1-Notch (show NOTCH1 Proteins) pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance.
Data show that Delta-like 4 (DLL4) and Jagged1 (JAG1) displayed equal potency in stimulating Notch target genes in HMEC-1 dermal microvascular endothelial cells but had opposing effects on sprouting angiogenesis in vitro.
Missense mutant of Jag1 (Jag1(Ndr (show STK38 Proteins))) disrupts bile duct development and is responsible for Alagille syndrome phenotypes in heart, eye, and craniofacial dysmorphology.
JAG1 was demonstrated to be a novel target of miR1405p, and miR1405p exerted its inhibitory effect on human glioma growth and invasion, partly by suppressing JAG1.
miR-141 may serve as an antioncomir in GSCs and markedly inhibit their self-renewal via downregulating Jagged1 expression levels in vitro and in vivo.
HIF1A (show HIF1A Proteins) potentiates Jagged 1-mediated angiogenesis by mesenchymal stem cell-derived exosomes.
These findings demonstrate a critical role of osteolineage Jagged1 in bone homeostasis, where Jagged1 maintains the transition of osteoprogenitor to maturing osteoblasts.
Data (including data from studies in transgenic mice) suggest that signaling via Notch2 (show NOTCH2 Proteins) and Notch3 (show NOTCH3 Proteins) plays role in promoting cell differentiation and steroidogenesis in preovulatory granulosa cells; mechanism involves regulation of gene expression of Jag1 and Rbpj (show RBPJ Proteins). (Notch2 (show NOTCH2 Proteins) = Notch2 (show NOTCH2 Proteins) receptor; Notch3 (show NOTCH3 Proteins) = Notch3 (show NOTCH3 Proteins) receptor; Jag1 = jagged-1 protein; Rbpj (show RBPJ Proteins) = recombining binding protein suppressor of hairless (show RBPJ Proteins))
Notch1 signaling is activated in brain endothelial cells cocultured with astrocytes, and astrocytic Jagged1 expression is required for angiogenic enhancement.
loss of Jag1 function in osteoblast lineage cells may contribute to the skeletal phenotype associated with Alagille syndrome.
Epidermal stem cells accelerate diabetic wound healing via the Notch1 (show NOTCH1 Proteins) signaling pathway; Jag1 overexpression improves diabetic wound healing in vivo.
pre-coated Notch1 (show NOTCH1 Proteins) protein promotes Notch1 (show NOTCH1 Proteins)-knocked down B cells to produce antibody in LPS (show TLR4 Proteins)-stimulated B cells suggesting that Notch1 (show NOTCH1 Proteins) in other cells may promote antibody production by binding its ligands Dll1 (show DLL1 Proteins) and Jag1 in B cells.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
the effects of two Notch (show NOTCH1 Proteins) ligands, i.e., Jagged1 and DLL1 (show DLL1 Proteins), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 Proteins) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1