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anti-Human NEDD4 Antibodies:
anti-Mouse (Murine) NEDD4 Antibodies:
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Mouse (Murine) Monoclonal NEDD4 Primary Antibody for IF, WB - ABIN968557
Harvey, Dinudom, Komwatana, Jolliffe, Day, Parasivam, Cook, Kumar: All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. in The Journal of biological chemistry 1999
Show all 4 Pubmed References
Mouse (Murine) Monoclonal NEDD4 Primary Antibody for IF, WB - ABIN968556
Hatakeyama, Jensen, Weissman: Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. in The Journal of biological chemistry 1997
Show all 4 Pubmed References
Human Polyclonal NEDD4 Primary Antibody for IHC (p), WB - ABIN4338483
Zhang, Li, Rezaeian, Xu, Chou, Jin, Han, Pan, Wang, Long, Zhang, Huang, Tsai, Tsai, Logothetis, Lin: H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. in Nature communications 2017
NEDD4 ligase regulates RTP801 (show DDIT4 Antibodies) and is sensitive to Parkinson disease-associated oxidative stress
Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported.
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Our results reveal a novel mechanism of upregulation of NEDD4 expression in pancreatic adenocarcinoma
Describe an autoinhibitory mechanism for NEDD4-1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1 (show SERTAD1 Antibodies). Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 (show SERTAD1 Antibodies) are identified by NMR titration experiments.
Our results demonstrate that NEDD4 may promote the acquired resistance of non-small-cell lung cancer cells to erlotinib by decreasing phosphatase and tensin homolog (show PTEN Antibodies) deleted on chromosome 10 protein expression. Targeted decrease in NEDD4 expression may be a potential therapeutic strategy for tyrosine kinase (show TXK Antibodies) inhibitor-resistant non-small-cell lung cancer.
this is the first demonstration that Nedd4-1 regulates hOAT1 (show SLC22A6 Antibodies) ubiquitination, expression, and transport activity through its WW2 and WW3 domains
both Nedd4-1 and Nedd4-2 (show NEDD4L Antibodies) are important regulators for hOAT1 (show SLC22A6 Antibodies) ubiquitination, expression, and function
expression or dysfunction of Nedd4 E3 ligase could be involved in vascular calcification of VSMCs by activating bone-forming signals during atherosclerosis progression
Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling.
NPM1 (show GJA1 Antibodies)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Antibodies) activation cascade.
these results suggest that Nedd4 suppresses colonic WNT (show WNT2 Antibodies) signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 (show LEF1 Antibodies) and YY1 (show YY1 Antibodies).
Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes.
Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Antibodies) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (show SUV420H2 Antibodies).
we propose that Nedd4 functions as a novel Pax7 (show PAX7 Antibodies) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (show PAX7 Antibodies) protein levels and therefore satellite cell fate.
PDLIM7 (show PDLIM7 Antibodies) is a bona fide skeletal muscle substrate of Nedd4-1.
show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation
Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 (show IRS2 Antibodies) in vivo.
miR-1-mediated regulation of Nedd4/Nedd4L (show NEDD4L Antibodies) expression may serve to broadly modulate the trafficking or degradation of Nedd4/Nedd4L (show NEDD4L Antibodies) substrates in the heart
Nedd4Lo destabilizes Amph (show AMPH Antibodies) in muscles, leading to impaired T-tubule formation and muscle function.
NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis
data in two evolutionarily distant model organisms strongly suggest that Nedd4 is a modifier of alpha-synuclein pathobiology and thus a potential target for neuroprotective therapies
Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking.
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis
Nedd4 regulates endocytosis of notch (show NOTCH1 Antibodies) and suppresses its ligand-independent activation.
These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout (show ROBO1 Antibodies) complex, critical for CNS and muscle development.
dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
E3 ubiquitin-protein ligase NEDD4
, cell proliferation-inducing gene 53 protein
, neural precursor cell expressed developmentally down-regulated protein 4
, receptor-potentiating factor 1
, neural precursor cell expressed, developmentally down-regulated gene 4
, neural precursor cell expressed, developmentally down-regulated gene 4a
, neural precursor cell expressed, developmentally down-regulted gene 4
, neural precursor cell expressed, developmentally down-regulated 4
, ubiquitin-protein ligase Nedd4
, E3 ubiquitin-protein ligase NEDD4-like
, e3 ubiquitin-protein ligase NEDD4-like
, neural precursor cell expressed, developmentally down-regulated gene 4A