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Browse our anti-SRRT (SRRT) Antibodies

Full name:: anti-Serrate RNA Effector Molecule Homolog (Arabidopsis) Antibodies (SRRT)

On www.antibodies-online.com are 30 Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) Antibodies from 9 different suppliers available. Additionally we are shipping SRRT Proteins (5) and many more products for this protein. A total of 39 SRRT products are currently listed.

Synonyms:: 2810019G02Rik, anon-WO0118547.166, Ars2, ars2-A, Asr2, ASR2A, ASR2B, ASR2C, ASR2D, CG7843, CHUNP6881, Dmel\\CG7843, MGC92060, serrate, zgc:92060

list all antibodies	Gene Name	GeneID	UniProt
	SRRT	51593	Q9BXP5
	SRRT	83701	Q99MR6
	SRRT
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Most Popular Reactivities for anti-SRRT (SRRT) Antibodies

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Top referenced anti-SRRT Antibodies

Human Polyclonal SRRT Primary Antibody for ELISA, WB - ABIN4281713 : Gruber, Olejniczak, Yong, La Rocca, Dreyfuss, Thompson: Ars2 promotes proper replication-dependent histone mRNA 3' end formation. in Molecular cell 2012 (PubMed)
Human Polyclonal SRRT Primary Antibody for ICC, IF - ABIN4281712 : Ke, Pang, Chen, Zhang, Wang, Zhu, Mao, Hu, Zhang, Cui: Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway. in Oncology reports 2019 (PubMed)

More Antibodies against SRRT Interaction Partners

Fruit Fly (Drosophila melanogaster) Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

Study identified Ars2 as a key component of Drosophila antiviral immunityp; loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses.

Human Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

Overexpression of Ars2 promoted cell proliferation and colony formation in glioblastoma cells, whereas the depletion of Ars2 inhibited cell proliferation, colony formation, and tumor growth. Knockdown of Ars2 reduced the expression levels of miR-6798-3p.
Depletion of Ars2 reduced the level of miR-6734-3p by inhibiting the interaction of Ars2 with either CBC complex or Drosha, leading to p27 up-regulation-mediated G1 cell cycle arrest, and culminating in inhibition of cell proliferation and leukemogenesis in AML
Deletion of Ars2 from adult mice resulted in defective hematopoiesis in bone marrow and thymus.Ars2 was required for survival of developing thymocytes and for limiting differentiation of bone marrow resident long-term hematopoietic stem cells. Ars2 knockout led to rapid thymic involution and loss of the ability of mice to regenerate peripheral blood after myeloablation.
Ars2 deficiency inhibited the activation of the MAPK/ERK pathway, leading to cell cycle arrest in the G1 phase, resulting in suppression of glioblastoma cell proliferation.
Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH.
define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription
ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci.
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells.
Ars2 is overexpressed in HCC and may have prognostic value; it might play an important role in HCC proliferation and miR-21 expression.
ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis.
Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21.
Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA.
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
Results suggest that FLASH functions in S phase progression through interaction with ARS2.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
Validated occurrence of an unusual TG 3' splice site in intron 17 (NM_015908).
Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2).

Mouse (Murine) Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.

SRRT Antigen Profile

Antigen Summary

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA)\; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Alternative names and synonyms associated with SRRT

Arsenic resistance protein 2 (Ars2) antibody
serrate, RNA effector molecule S homeolog (srrt.S) antibody
serrate, RNA effector molecule (SRRT) antibody
serrate RNA effector molecule homolog (Arabidopsis) (Srrt) antibody
serrate, RNA effector molecule (Srrt) antibody
serrate RNA effector molecule homolog (Arabidopsis) (srrt) antibody

2810019G02Rik antibody
anon-WO0118547.166 antibody
Ars2 antibody
ars2-A antibody
Asr2 antibody
ASR2A antibody
ASR2B antibody
ASR2C antibody
ASR2D antibody
CG7843 antibody
CHUNP6881 antibody
Dmel\\CG7843 antibody
MGC92060 antibody
serrate antibody
zgc:92060 antibody

Protein level used designations for SRRT

, , , , , , , , , , , , , , , , , , , Ars2-PA Ars2-PC Ars2-PD Ars2-PE Ars2-PF Ars2-PG CG7843-PA CG7843-PC CG7843-PD CG7843-PE CG7843-PF CG7843-PG Arsenite-resistance protein 2-A serrate RNA effector molecule homolog A arsenate resistance protein 2 arsenate resistance protein ARS2 arsenite resistance protein arsenite-resistance protein 2 serrate RNA effector molecule homolog Arsenite-resistance protein 2

GENE ID	SPECIES
35539	Drosophila melanogaster
100037061	Xenopus laevis
51593	Homo sapiens
83701	Mus musculus
527938	Bos taurus
100689205	Cricetulus griseus
192311	Danio rerio

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