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The major conclusions of this study are that WSTF acts as an activator of ER signaling in MCF-7 breast cancer cells, that this action can be inhibited by 1alpha,25-dihydroxyvitamin D3, and that the expression of WSTF is higher in breast cancer tissue than in normal tissue. WSTF may by a new target for treatment of estrogen-dependent breast cancer cell growth.
promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin
Data show that Williams-Beuren syndrome transcription factor (WSTF) release was mediated by neuregulin-3 (NRG3) following KRASG12V expression in intestinal epithelial cells.
WSTF may act as an oncoprotein in lung cancer to accelerate tumor aggressiveness.
A pivotal role for BAZ1B in neurodevelopment was revealed and its haploinsufficiency was implicated as a likely contributor to the neurological phenotypes in Williams syndrome through transcriptional dysregulation.
Data indicate that the heterochromatic H2A.X is preferentially phosphorylated presumably by the accumulating WSTF-ISWI chromatin remodeling (WICH) complex, and suggests that Tyr142p might have a specific role in heterochromatin.
EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter.
This review describes the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity.
A multiprotein complex containing WSTF, nuclear myosin 1 (NM1), and SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 5 protein(SNF2h) is required for ribosomal DNA transcription.
WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling
WSTF phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response
BAZ1B, a component of chromatin remodeling complexes, in the nucleus accumbens regulates reward-related behaviors in response to chronic exposure to both rewarding and aversive stimuli
WSTF phosphorylates Tyr 142 of H2A.X, and that WSTF activity has an important role in regulating several events that are critical for the DNA damage response
WSTF knockdown results in a severe defect in neural crest migration.
This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
bromodomain adjacent to zinc finger domain, 1B
, tyrosine-protein kinase BAZ1B-like
, transcription factor WSTF
, tyrosine-protein kinase BAZ1B
, williams syndrome transcription factor
, williams-Beuren syndrome chromosomal region 10 protein
, williams-Beuren syndrome chromosomal region 9 protein
, Williams-Beuren syndrome chromosome region 9 homolog
, bromodomain adjacent to zinc finger domain protein 1B
, bromodomain adjacent to zinc finger domain, 1B; Williams-Beuren syndrome chromosome region 9 homolog
, williams syndrome transcription factor homolog
, williams-Beuren syndrome chromosomal region 9 protein homolog
, Williams syndrome transcription factor homolog
, Bromodomain adjacent to zinc finger domain protein 1B