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Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC (show FAM126A Proteins)) and that dysregulation of miR (show MLXIP Proteins)-362 and Tob2 may contribute to HCC (show FAM126A Proteins) malignancy.
The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.
study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation
TNFalpha (show TNF Proteins) is able to transactivate ErbB-2 (show ERBB2 Proteins) and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals.
Haploinsufficiency of the MLL (show MLL Proteins) and TOB2 genes in lymphoid malignancy.
Antiproliferative proteins of the BTG/Tob (show TDO2 Proteins) family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1 (show BTG1 Proteins), BTG2 (show BTG2 Proteins), Tob (show TDO2 Proteins), and Tob2 proteins.
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs (show NR2E3 Proteins)) grew faster than wild type (WT) ESCs (show NR2E3 Proteins) without losing pluripotency.
miR (show MLXIP Proteins)-322 and its target protein Tob2 modulate Osx (show SP7 Proteins) mRNA stability
Tob2 protein suppresses PPARgamma2 (show PPARG Proteins) transcription by inhibiting BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)/5 phosphorylation through its interaction with Smad6 (show SMAD6 Proteins) and by sequestering C/EBPalpha (show CEBPA Proteins) from the PPARgamma2 (show PPARG Proteins) promoter.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL (show TNFSF11 Proteins) expression through its interaction with vitamin D receptor (show VDR Proteins)
TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.
, transducer of ERBB2, 2
, protein Tob4
, transducer of erbB-2 2